Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women
Background
Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis.
Objective
The objective of this study was to evaluate the impact of a dairy product fermented with probiotic bacteria on aspects of brain structure …
British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease
Patients with inflammatory bowel disease (IBD) remain at increased risk for colorectal cancer and death from colorectal cancer compared with the general population despite improvements in inflammation control with advanced therapies, colonoscopic surveillance and reductions in environmental risk fa…
Psychological burden and its association with preferred form of psychological assistance of healthcare workers during the COVID-19 pandemic in China: a cross-sectional study
Objective
This study focused on the preferences for psychological assistance and associated factors among Chinese healthcare workers (HCWs) during the COVID-19 pandemic.
Design
Cross-sectional analysis of survey data collected from Chinese HCWs during the COVID-19 pandemic.
Setting
Nationwide psych…
Effect of medical school initiatives on help seeking for mental health problems among medical students: a systematic review and meta-analysis
Objectives
Many medical students with mental health problems do not seek help. However, it is unclear what medical schools can do to promote help seeking. We sought to establish the effect of medical school initiatives on help seeking for mental health problems among medical students.
Design
A syst…
Effect of enhanced support for coping with side effects during medication counselling on the nocebo effect in patients with advanced lung cancer receiving initial chemotherapy: protocol for a multicentre exploratory open-label randomised controlled trial
Introduction
Chemotherapy-induced nausea and vomiting (CINV) is a common symptom in cancer, and it is one of the distressing symptoms in patients with cancer receiving chemotherapy. Information about side effects may exacerbate CINV due to the nocebo effect. This study aims to examine the efficacy …
Adolescent community reinforcement approach in secure care for adolescents with substance use and serious norm-violating behaviour: a randomised feasibility trial
Background
Adolescents placed in state-run secure youth homes (by the Swedish National Board of Institutional Care) due to substance misuse and serious norm-violating behaviour (including offending) are in pressing need of effective help, yet available treatments lack scientific support. The treatm…
Protocol for a multimethods study evaluating a transition pathway between hospital settings and postsecondary institutions: the NavigateCAMPUS study
Introduction
The surge in postsecondary students reporting mental health concerns, coupled with increased utilisation of on-campus and hospital-based mental healthcare, highlights a need to understand effective service navigation. To address this system gap, the University of Toronto and the Centre…
Coronary Atherosclerosis in Patients With Cancer and Survivors: A Scientific Statement From the American Heart Association
Circulation, Ahead of Print. There is an emerging convergence between atherosclerotic cardiovascular disease and cancer, driven by shared risk factors and overlapping pathophysiologic mechanisms. Traditional factors, such as smoking, aging, obesity, hypertension, and diabetes, alongside novel marke…
Exploring the impact of targeted exercise in women experiencing homelessness, addiction and mental health challenges: a mixed-methods feasibility study
Objective
Low physical functioning and frailty are prevalent in non-geriatric vulnerable populations such as people experiencing homelessness, addiction and mental health challenges. The objective of this study was to explore the feasibility and impact of a targeted exercise intervention with prote…
Association between severe maternal morbidity and health service use in the first postpartum year: a population-based retrospective cohort study in British Columbia, Canada
Objectives
To assess health service use between days 43 and 365 postdelivery, comparing individuals with and without severe maternal morbidity (SMM).
Design
Population-based cohort study.
Setting
Linked datasets from Population Data BC in British Columbia, Canada, April 2013–March 2021.
Participant…
Multicentre international observational study on airway management for anaesthesia: the STARGATE study protocol
Introduction
More than 300 million major surgical procedures are carried out under general anaesthesia each year worldwide, and advanced airway management remains one of the leading daily challenges for clinicians. Data from large international prospective cohort studies on adverse events such as c…
Insulin Resistance Compromises the Pentose Phosphate Pathway and Impairs Left Ventricular Assist Device–Mediated Myocardial Recovery in Obese Patients with Heart Failure
Circulation, Ahead of Print. BACKGROUND:End-stage heart failure (HF) remains a major global health challenge, and left ventricular assist devices (LVADs) represent an important therapeutic option. LVAD-mediated mechanical unloading improves cardiac function and promotes myocardial recovery in many …
The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis
Circulation, Ahead of Print. BACKGROUND:Acute myocardial infarction caused by thrombosis is a major cause of mortality. A polymorphism in aldehyde dehydrogenase 2 (Aldh2) rs671 is found in approximately 30% to 50% of East Asians, and it is a risk factor for acute myocardial infarction. This mutatio…
TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis
Circulation, Ahead of Print. BACKGROUND:Ischemic heart disease is one of the leading causes of death worldwide. Timely reperfusion is necessary for myocardium salvage but triggers paradoxical cardiomyocyte death and contributes to up to 50% of the final infarct size, known as lethal ischemia/reperf…
Perinatal Arterial Ischemic Stroke Phase 3 Trial Protocol for Intensive Infant-Toddler Rehabilitation (I-ACQUIRE)
Stroke, Ahead of Print. BACKGROUND:Infants and toddlers with perinatal arterial ischemic stroke face a high risk for lifelong neuromotor impairments and multiple disabilities. Phase 3 clinical trial evidence is urgently needed to identify efficacious treatment to improve outcomes.METHODS:The I-ACQU…
Linea guida inter-societaria per la gestione della multimorbilità e polifarmacoterapia
Farmacologia e TossicologiaL’invecchiamento della popolazione ha determinato un marcato incremento della prevalenza di multimorbilità e polifarmacoterapia,...
