[Articles] Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study
In patients of advanced age, IVL for calcified coronary lesions demonstrates a favorable safety and efficacy profile, with high technical success and low rates of device-related adverse events. Nonetheless, larger studies with extended follow-up are warranted to confirm these findings and establish…
Post- Dobbs Changes in OBGYN Clinical Workforce
This case-control study compares the availability of women’s health care clinicians in states that enacted highly restrictive abortion policy after the Dobbs Supreme Court decision vs states that established abortion legislation before the Dobbs decision.
[Articles] Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, exploratory, placebo-controlled, double-blind, randomised phase IIa clinical trial (RCT)
As this proof-of-concept study showed effects on the patient-centred endpoint PCS and a good safety profil, subsequent studies are needed to confirm these results in a larger cohort.
Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide
Annals of Internal Medicine, Ahead of Print.
[Articles] Development and validation of a novel prognostic model to predict 1-year post-transplant mortality for acute-on-chronic hepatitis B liver failure: a nationwide, multicentre, cohort study
The HALT model showed superior predictive ability over eight current models and may help for LT candidate selection and optimal organ allocation. Though the findings need to be verified in prospective studies and among different patient populations.
Purastat post-EMR: unresolved questions from the PURPLE trial
We read with interest the recently published PURPLE trial evaluating the prophylactic use of Purastat to prevent delayed bleeding following EMR of large duodenal and colorectal lesions.1 While we acknowledge the importance of randomised trials in shaping clinical practice, several methodological co…
[Articles] Treatment effects of Xuebijing injection in patients with sepsis by clinical phenotype: a post hoc analysis of the EXIT-SEP trial
We replicated four sepsis phenotypes in the EXIT-SEP cohort, with patterns similar to previously established phenotypes. XBJ treatment was associated with lower 28-day mortality in patients with phenotypes γ and δ, but these findings require further validation.
Epilessie nei bambini e negli adolescenti
EpilessiaL’epilessia è una grave condizione neurologica che colpisce circa i bambini sotto i 18 anni con molte nuove diagnosi ogni anno. Si...
ACC: linee guida su obesità e scompenso cardiaco
Endocrinologia e Malattie MetabolicheNuove linee guida ACC per il trattamento dell’obesità evidenziano strategie individualizzate e terapie emergenti. Farmaci approvati per...
Alzheimer e Ictus: Scoperta la proteina killer dei neuroni
Notizie dalla RicercaI ricercatori della Johns Hopkins University School of Medicine, Baltimore dicono di aver individuato la proteina responsabile della morte...
Un farmaco per il diabete potrebbe curare l’Alzheimer.
Notizie dalla RicercaUn farmaco comunemente usato nel trattamento del diabete può invertire i sintomi della malattia di Alzheimer in fase avanzata. Ad...
GI highlights from the literature
Basic scienceSensing pain in the gut: new insights into enterochromaffin cells Touhara K, Rossen N, Deng F et al Topological segregation of stress sensors along the gut crypt-villus axis. Nature 2025; 640(8059): 732-742. doi: 10.1038/s41586-024-08581-9. The gut barrier is monitored by enterochromaf…
PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations
Circulation, Ahead of Print. BACKGROUND:Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (ALK1) cause type 2 hereditary hemorrhagic telangiectasia, andAlk1knocko…
L’arma segreta dell’olio d’oliva contro l’Alzheimer: i composti fenolici
Notizie dalla RicercaUna revisione completa sull’International Journal of Molecular Sciences evidenzia il potenziale dell’olio extravergine di oliva e dei...
Comprensione, prevenzione e trattamento della demenza vascolare
DemenzaUno studio condotto dagli Ospedali universitari di Ginevra (HUG) e dall’Università di Ginevra (UNIGE) getta una luce significativa sulla...
