Response by Balligand and Michel to Letter Regarding Article, “An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress”
Circulation, Volume 152, Issue 25, Page e492-e493, December 23, 2025.
Letter by Hang et al Regarding Article, “An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress”
Circulation, Volume 152, Issue 25, Page e490-e491, December 23, 2025.
ACC/AHA: linee guida per la gestione delle cardiopatie congenite negli adulti
CardiovascolareL’ACC e l’AHA, in collaborazione con diverse importanti società mediche, hanno pubblicato una nuova linea guida clinica incentrata...
Gestione della malattia arteriosa periferica negli adulti con diabete: linea guida
CardiovascolareL’American College of Cardiology (ACC) ha pubblicato un nuovo documento scientifico che fornisce raccomandazioni basate su...
Gestione della steatosi epatica associata a disfunzione metabolica (MASLD): linee guida cliniche EASL–EASD–EASO
Gastroenterologia ed EpatologiaL’European Association for the Study of the Liver (EASL), l’European Association for the Study of Diabetes (EASD) e...
IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes
Circulation, Ahead of Print. BACKGROUND:We report IMPROVE-DiCE (Improve Diabetic Cardiac Energetics), a 2-part open-label, phase 2a trial evaluating the safety and effectiveness of ninerafaxstat, a novel therapeutic designed to enhance cardiac energetics. Between May and September 2021, part 1 enro…
Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothelial Toxicity and Cardiac Dysfunction
Circulation, Ahead of Print. BACKGROUND:Doxorubicin (DOX), an effective chemotherapeutic drug for various cancers, has been demonstrated to induce cardiovascular toxicity in cancer survivors. Endothelial cell (EC) dysfunction is recognized to play a critical role in the onset and severity of cardio…
Standard di cura per il Diabete – 2026
Endocrinologia e Malattie MetabolicheL’American Diabetes Association (ADA) ha pubblicato gli “Standards of Care in Diabetes—2026“, linee guida basate su evidenze...
ESC 2025: Linee guida sulla gestione delle miocarditi e pericarditi
CardiovascolareL’European Society of Cardiology ha aggiornato nel 2025 le linee guida dedicate alla gestione della miocardite e della pericardite,...
[Articles] Artifical intelligence-powered delta-NIHSS-based model for predicting recurrence, disability and mortality after acute ischaemic strokes (DISCO): a modelling study
The DISCO model, incorporating 23 clinical variables, demonstrates high accuracy, robustness, clinical accessibility, and explainability in predicting post-stroke outcomes. The predictive strength of delta-NIHSS(admission-discharge) provides mechanistic insights into stroke outcomes and could poten…
[Articles] Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatment
Our qualitative findings suggests that psilocybin treatment, when administered with standardised preparation and treatment support, may offer a meaningful therapeutic opportunity for Patients with PTSD. Future work should include larger controlled studies and use mixed methods to explore how sympto…
Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling
The intricate interplay between the gut microbiota and the GI tract has garnered significant attention, as growing evidence has identified the inflammasome as a crucial yet underexplored master regulator in microbiota-driven diseases. Triggered by a variety of dangers, inflammasomes are supramolecu…
Reassessing the prophylactic effect of clip closure to prevent delayed rebleeding after colorectal endoscopic submucosal dissection
We read with great interest the recent EPOC trial by Miyakawa et al, published in Gut, investigating the efficacy of prophylactic clip closure following colorectal endoscopic submucosal dissection (ESD). The authors deserve recognition and appreciation for conducting a well-designed, multicentre ra…
Prevenzione, diagnosi e gestione della BPCO (GOLD 2026)
BPCOPresentato l’aggiornamento 2026 delle linee guida del Global Initiative for Chronic Obstructive Lung Disease (GOLD) durante la...
Adesione ai trattamenti ASA + Statine in medicina generale: evidenze da uno studio italiano real-world
Notizie dalla RicercaQuesto studio real-world basato mostra un punto molto chiaro: i pazienti che assumono ASA e statina come due farmaci separati hanno livelli...
