Impact of syncope history on long-term physical activity in patients >=2 years after transcatheter aortic valve replacement: a single-centre cross-sectional study in China
Objective
To explore long-term physical activity (PA) among patients 2 years post-transcatheter aortic valve replacement (TAVR) and assess the impact of syncope history on post-TAVR activity.
Design
This was a cross-sectional study conducted using an on-site questionnaire.
Setting
In this cross-sec…
Relationships between alcohol use and dementia: protocol for an observational study in the UK Clinical Practice Research Datalink
Introduction
Alcohol consumption is an increasingly recognised modifiable risk factor for dementia, yet whether it has differential impacts on dementia subtypes and its role in disease progression remains unclear. This study aims to: (1) quantify the association between alcohol intake and incidence…
Is intensive behavioural change enhanced with dialectical behavioural therapy feasible for weight management in adolescents living with higher body weight? A protocol for a pilot randomised controlled trial in three centres in Canada
Introduction
For adolescents living with higher body weight, changing lifestyle behaviours can be met with challenges due to psychosocial factors, such as mental health and emotional challenges. Few behavioural interventions have included skill development to manage these mental health and emotiona…
Artificial intelligence to improve the detection and risk stratification of acute pulmonary embolism (AID-PE): protocol for a pragmatic quasi-experimental comparator study
Introduction
Pulmonary embolism (PE) is a potentially fatal condition requiring timely diagnosis and treatment. CT pulmonary angiography (CTPA) is the gold standard for diagnosis and indicates PE severity through radiological markers of right heart strain. However, accurate interpretation and commu…
Effects of acupuncture and mindfulness-based stress reduction for chronic non-specific low back pain: study protocol for a 2×2 factorial randomised controlled trial
Background
Chronic non-specific low back pain (CNLBP) is a multifactorial disease involving physical dysfunction and psychological distress. Acupuncture and mindfulness-based stress reduction (MBSR) are two non-pharmacological therapies recommended by guidelines, which have been proven effective in…
Association of symptoms at heart failure diagnosis with hospitalisation and mortality at 6 and 12 months: a retrospective cohort study using UK primary care health records
Background
We investigated symptoms reported before and after heart failure (HF) diagnosis and their associations with 3-month hospitalisation and mortality.
Objectives
To examine associations between symptoms recorded in primary care and short-term hospitalisation and mortality in HF patients.
Des…
Raccomandazioni italiane per la gestione della malattia da reflusso gastroesofageo (MRGE): aggiornamento 2025
Gastroenterologia ed EpatologiaLa malattia da reflusso gastroesofageo (GERD) rappresenta una delle condizioni più frequenti nella pratica clinica ambulatoriale, sia in...
Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring
Stroke, Ahead of Print. BACKGROUND:Intergenerational disease transmission, where parental exposures or experiences influence disease susceptibility in offspring, may represent a crucial layer of stroke risk that extends beyond genetics alone. Environmental conditioning, such as intermittent subleth…
Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1
Circulation, Ahead of Print. BACKGROUND:During myocardial infarction (MI), M1-like macrophages exacerbate myocardial injury by excessively secreting inflammatory cytokines. Therefore, modulating the activity of M1-like macrophages may represent a novel therapeutic strategy for MI. PRMTs (protein ar…
AHA: Aterosclerosi coronarica nei pazienti con cancro
CardiovascolareQuesta dichiarazione scientifica dell’American Heart Association, sintetizza le prove sull’interazione tra cancro e...
Involvement of Eosinophil-Driven Intestinal Immune Activation in Different Irritable Bowel Syndrome Subtypes and in the Response to a FODMAP Lowering Diet: A Post Hoc Analysis of the Randomized Controlled DOMINO Trial
Irritable bowel syndrome (IBS) is defined by symptoms of recurrent abdominal pain related to defecation and is categorized into the following 4 subgroups: IBS with predominant constipation (IBS-C), diarrhea (IBS-D), mixed (IBS-M), and unsubtyped. Despite its widespread impact, the pathophysiology o…
Longitudinal study of childbirth readiness and its related factors and consequences among low-risk pregnant women attending health centres in Tabriz, Iran
Objective
Childbirth readiness can reflect women’s childbirth readiness in terms of knowledge, psychological aspects and planning. The purpose of this study was to evaluate childbirth readiness, its related factors and consequences in Iranian pregnant women.
Design
This longitudinal study was the f…
Post–Intensive Care Syndrome
This JAMA Insights discusses post–intensive care unit syndrome, including how it is assessed and diagnosed as well as suggestions for treatment and prevention.
Going Back to “Normal” After ICU Discharge: JAMA Film Documents Post–Intensive Care Syndrome (PICS)
This JAMA film documents the story of an intensive care unit survivor who developed post–intensive care syndrome (PICS), featuring interviews with clinicians and researchers to explore what PICS is, what causes it, and ways to help patients.
Real-world impact of implementing lumen-apposing metal stents for pancreatic fluid collections: a nationwide Japanese study
Background
Lumen-apposing metal stents (LAMSs) are increasingly used for the endoscopic management of pancreatic fluid collections (PFCs), including walled-off necrosis (WON) and pancreatic pseudocysts (PCs).
Objective
To evaluate the nationwide impact of implementing an LAMS (approved in Japan in …
LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis
Alcohol-associated hepatitis (AH) remains one of the most severe and life-threatening manifestations of alcohol-related liver disease (ALD). It is characterised by rapid onset, limited treatment options and high short-term mortality.1 One of the pathological hallmarks of AH is excessive activation …
