Distinct gene expression mechanisms in classical and basal PDAC subtypes
Pancreatic ductal adenocarcinoma (PDAC) represents approximately 90% of all malignant tumours in the pancreas, and it is one of the deadliest human diseases. It has a 5-year survival rate of less than 10%, primarily due to the lack of early symptoms and of effective therapies. With its rising incid…
Assessing the feasibility of a platform trial for Gram negative bloodstream infections: results from the vanguard phase of BALANCE+
Objectives
Gram negative bloodstream infections (GN BSI) are a leading cause of mortality worldwide, and antibiotic treatment approaches remain understudied. BALANCE+ is a perpetual Bayesian adaptive platform trial to test multiple treatment questions for hospitalised patients with GN BSI. The vang…
Polmonite complessa e infezione parassita, bimbo salvato a Siena
Due interventi combinati e ad alto rischio a ospedale Scotte
Stress Hyperglycemia Ratio and Adverse Outcomes in Acute Mild Ischemic Stroke or High-Risk Transient Ischemic Attack: A Secondary Analysis of the INSPIRES Trial
Stroke, Ahead of Print. BACKGROUND:Evidence on the association between the stress hyperglycemia ratio (SHR) and adverse outcomes in patients with mild ischemic stroke (IS) or high-risk transient ischemic attack remains limited.METHODS:This was a secondary analysis of the INSPIRES (Intensive Statin …
Predisposing Factors, Pathologies, and Precipitating Factors Causing Intracerebral Hemorrhage
Stroke, Ahead of Print. Most people with spontaneous intracerebral hemorrhage (ICH) have hypertension, which is the strongest modifiable predisposing (risk) factor. However, multiple long-term medical conditions and other known predisposing factors for ICH usually coexist with hypertension, indicat…
Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association
Circulation, Ahead of Print. Metabolic and genetic abnormalities have long been noted in cardiovascular diseases, but the contribution of mitochondrial genetic (mitochondrial DNA mtDNA) variation is understudied. Mitochondrial genetics is complex in that each mitochondrion contains multiple mtDNA c…
The Role of Alcohol in Pancreatic Diseases: A Comprehensive Perspective
Alcohol abuse is a leading cause of global health care concerns and can cause health loss, disease, and death. In addition to the liver, the pancreas is a vital organ for the metabolism of alcohol, especially nonoxidative metabolism, and alcohol abuse is the leading cause of pancreatic diseases wor…
Divergent GFR Estimates and Clinical Implications
Chronic kidney disease (CKD) affects more than 800 million people worldwide, significantly increasing the risk for kidney failure, cardiovascular disease, and all-cause mortality. Accurate assessment of glomerular filtration rate (GFR) is essential for identifying and managing CKD. Although GFR is …
Clinical Obesity and All-Cause and Cause-Specific Mortality in UK Biobank
This study evaluates the association between a new definition of obesity with mortality data in the UK Biobank.
Pharmacologic Confounders in Steatotic Liver Disease Outcomes Research
To the Editor We read with great interest the recent article by Ochoa-Allemant et al, who reported on the long-term outcomes of steatotic liver disease (SLD) subtypes, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and the overlap…
Thrombolysis With the Nonimmunogenic Staphylokinase for Acute Ischemic Stroke in FORPI Registry: An Observational Study
Stroke, Ahead of Print. BACKGROUND:The nonimmunogenic staphylokinase is a recombinant staphylokinase with low immunogenicity, high thrombolytic activity, and fibrin selectivity approved in Russia for the acute ischemic stroke (AIS) thrombolytic therapy within 4.5 hours after symptom onset. We evalu…
Incidence and Mortality of Chronic Subdural Hematomas: A Population-Based Study
Stroke, Ahead of Print. BACKGROUND:Despite a rising public health burden, there have been few population-based studies of chronic subdural hematomas (cSDH) in the United States. We provide the first estimates of cSDH incidence and mortality in a large, representative U.S. population.METHODS:In a re…
Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade
Circulation, Ahead of Print. BACKGROUND:Atrial fibrillation and other cardiac arrhythmias pose a major public health burden, but prevention remains difficult. We investigated a genetic variant that we found to act like a natural lifelong cardiac sodium channel blockade.METHODS:We studied the impact…
Prevalence, Predictors, and Prognosis of Depression After Transient Ischemic Attack: A Population-Based Study
Stroke, Ahead of Print. BACKGROUND:Depression is common after stroke and is associated with increased mortality. However, there are few data on the prevalence, predictors, or prognosis of depression after transient ischemic attack (TIA). Although poststroke depression is often assumed to be due to …
Giornata dei diritti dei bambini: 5 regole per proteggere i giovani
Dipendenza – Diritti dei bambini: le indicazioni per tutelare salute e benessere dei giovani: disconnessione, sicurezza digitale, gaming regolato, stop fumo e alcol.
Community-Acquired Meningitis: Watch Out for Klebsiella
In South Korea, Klebsiella pneumoniae surpassed pneumococci as the leading cause of community-acquired meningitis.
