Impact of COVID-19 on the detection of tuberculosis in Guangdong, China based on the autoregressive integrated moving average model: a time-series study
Objective
China has continued to improve tuberculosis (TB) control in the past decade; however, the sudden outbreak of COVID-19 hindered this progress. As a province with a large population and frequent international exchanges, Guangdong has been seriously affected by COVID-19. This study aimed to …
Standard di cura per il Diabete – 2026
Endocrinologia e Malattie MetabolicheL’American Diabetes Association (ADA) ha pubblicato gli “Standards of Care in Diabetes—2026“, linee guida basate su evidenze...
Toward AI-Powered Neurovascular Intervention: From Imaging to XR-Robotic Convergence
Stroke, Ahead of Print. Stroke remains a leading cause of mortality and long-term disability worldwide, where rapid diagnosis and timely intervention are critical for improving outcomes. Neurovascular imaging modalities, including magnetic resonance angiography, computed tomography angiography, mag…
Ocse, Italia prima in Ue per aspettativa di vita
84,1 anni. Malattie cardiovascolari e cancro prime cause di morte
Effects of glucagon-like peptide-1 analogues on hard binary outcomes for patients at increased risk of cardiovascular events: a protocol for a systematic review with network meta-analysis and Trial Sequential Analysis
Background
Cardiovascular diseases, overweight, type 2 diabetes and chronic kidney disease increase the risk of cardiovascular events.
Glucagon-like peptide-1 analogues are recommended by the European Society of Cardiology and the American College of Cardiology to lower the risk of death and progre…
Increasing the pneumonia treatment coverage among children under 5 years old through ‘Enhanced Management of Pneumonia in the Community: implementation research protocol
Introduction
Pneumonia remains a leading cause of under-5 mortality in sub-Saharan Africa, accounting for approximately 14% of deaths in this age group. In Malawi, pneumonia accounts for 12% of under-5 deaths, with recent data revealing a concerning trend of over 110 000 new cases reported in 6 mon…
Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in ‘Difficult to Treat depression: protocol for a systematic review and individual participant data meta-analysis of randomised controlled trials
Introduction
About 30% of depressed patients suffer from a protracted course in which the disorder continues to cause significant burden despite treatment efforts. While originally developed for relapse prevention, mindfulness-based cognitive therapy (MBCT) has increasingly been investigated in dep…
Self-management measurement instruments specific to individuals with cardiovascular diseases: a systematic review protocol using COSMIN methodology
Introduction
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, making the development of self-management strategies crucial for preventing complications and improving clinical outcomes. This process involves symptom monitoring, treatment adherence, emotional management and a …
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury
This randomized clinical trial examines whether sodium bicarbonate infusion decreases day 90 all-cause mortality for patients with severe metabolic acidosis and moderate to severe acute kidney injury.
Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the ‘MOI-A study; a randomised, phase 2/pilot, dose-escalating trial
Introduction
Osteogenesis imperfecta (OI) is the most common inherited cause of bone fragility (approximately 1 in 16 000). People with OI suffer bone fragility causing fractures, pain and deformity; sarcopenia causing fatigue and poor endurance; aortic root dilatation and hearing loss. No drug cur…
‘Con smartphone prima dei 12 anni aumenta rischio depressione’
Anche di insonnia e obesità. Lo studio su 10.000 bambini
Dolore cronico, tra possibili cause anche traumi irrisolti
Lo studio. Ascione, ‘corpo custodisce le esperienze avverse’
Influenza per quasi 600mila in 7 giorni, in tutto 3,3 milioni
Iss, i più colpiti i bambini fino a 4 anni
Switching From Aspirin Monotherapy After Noncardioembolic Stroke: A Systematic Review and Network Meta-Analysis
Stroke, Ahead of Print. BACKGROUND:Patients who experience an ischemic stroke while on aspirin therapy present a clinical dilemma about optimal long-term secondary prevention. While switching to an alternative antithrombotic agent is often considered, the effectiveness of switching remains uncertai…
Glycaemic control is a modifiable risk factor for pancreatic cancer development in patients with diabetes: a population-based cohort study
Background
Effect of glycaemic control on pancreatic cancer (PC) development in patients with long-standing type 2 diabetes (T2D) remains unclear.
Objective
To investigate effects of glycaemic control on PC development in patients with T2D.
Design
Retrospective cohort study.
Methods
Adults from a t…
