Melanoma, una molecola mette il turbo all’immunoterapia pre-intervento
Al via studio, obiettivo ridurre le recidive in tumori avanzati
Melanoma, molecola mette il turbo a immunoterapia pre-intervento
Al via studio, obiettivo ridurre le recidive in tumori avanzati
Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling
The intricate interplay between the gut microbiota and the GI tract has garnered significant attention, as growing evidence has identified the inflammasome as a crucial yet underexplored master regulator in microbiota-driven diseases. Triggered by a variety of dangers, inflammasomes are supramolecu…
Con la mappa delle cellule del melanoma si prevede la risposta a immunoterapia
Studio, possibile con l’uso congiunto di biologia spaziale e IA
Con mappa cellule melanoma si prevede risposta a immunoterapia
Studio, possibile con uso congiunto di biologia spaziale e IA
ETV5-S100A9 feed-forward loop connecting HCC and MDSCs to shape the immunosuppressive tumour microenvironment
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related deaths worldwide, accounting for approximately 800 000 deaths annually. Treatment options for unresectable, advanced-stage HCC are very limited. For decades, tyrosine kinase inhibitors…
A Risk Prediction Tool for Invasive Melanoma
This prospective cohort study with a 10-year follow-up period aims to develop and validate an improved melanoma risk prediction tool for invasive melanoma.
Proton Craniospinal Irradiation for Leptomeningeal Metastases
Leptomeningeal metastasis (LM) is among the most formidable and devastating challenges in oncology and has long eluded effective treatments. With a historically dismal prognosis, the incidence of LM appears to be increasing due, in part, to an improved lifespan for patients with metastatic cancer a…
Changing Role of Adjuvant Therapy in Stage III Melanoma
New England Journal of Medicine, Ahead of Print.
Is Wide Local Excision After Primary Excision of Melanoma In Situ Unnecessary?
Dessinioti and coauthors present a retrospective study undertaken in Greece reporting the clinical outcomes for 401 people diagnosed and treated for melanoma in situ from 1991 to 2023 at a major melanoma referral center in Athens (non–lentigo maligna and nonacral lentiginous melanomas; median range…
Local Recurrence and Survival in Patients With Melanoma In Situ
This cohort study evaluated the rate of local recurrence, metastasis, and melanoma-specific death in patients with melanoma in situ treated with excisional biopsy or wide excision alone.
Patient-Reported Outcome Measures and Validation Data Used in Melanoma Research and Routine Practice
This systematic review identifies patient-reported outcome measures that have been used in melanoma research and clinical practice and related melanoma-specific validation data.
Tumori della pelle: aumentano i casi tra i giovani in Italia
Melanoma – Melanoma e tumori della pelle in aumento, ma nuove terapie riducono recidive e migliorano la sopravvivenza. Controlli dermatologici ancora troppo scarsi.
Global Applicability of a Predictive Tool for Sentinel Node Positivity in Patients With Primary Cutaneous Melanoma
This cohort study further validates the Melanoma Institute Australia sentinel node metastasis risk calculator in other non-Australian melanoma populations to evaluate its global applicability.
Area Deprivation Index and Melanoma Thickness in Veterans
This cohort study evaluates if neighborhood deprivation is associated with thicker (greater than 2 mm) cutaneous melanoma diagnosis after controlling for individual-level characteristics in the US veteran population.
Melanoma-Associated Leukoderma
This case report describes a woman with color change involving only the facial skin and was later found to also have inguinal lymph node and rectal mass.
