Corre l’influenza, il picco si avvicina e in Inghilterra è già allarme: “La sfida più seria dopo la pandemia”
Sale ancora la curva dell’influenza e si avvicina il picco di casi che potrebbe arrivare già a fine mese: la scorsa settimana, secondo il sistema di sorveglianza RespiVirNet dell’Istituto Superiore…
Patient perspectives on the usability and content validity of the assessment of burden of chronic conditions tool for post-COVID in the Netherlands: a qualitative study
Background
Post-COVID syndrome manifests with a diverse array of symptoms for which no standard care plan currently exists. Many questions were raised by patients, which underscored the need for a validated patient-reported outcome measure (PROM). Therefore, a post-COVID module was developed to be …
Anatomic versus reverse total shoulder replacement for patients with osteoarthritis and intact rotator cuff: the RAPSODI-UK randomised controlled trial protocol
Introduction
Shoulder osteoarthritis most commonly affects older adults, causing pain, reduced function and quality of life. Total shoulder replacements (TSRs) are indicated once other non-surgical options no longer provide adequate pain relief. Two main types of TSRs are widely used: anatomic TSR …
Association between depressive symptoms and tuberculosis diagnosis stage in older adults: a 4-year longitudinal cohort study in rural South Africa
Objectives
While tuberculosis (TB) is associated with increased depressive symptoms, the long-term mental health trajectory post-diagnosis in low-resource settings remains poorly understood. This study investigated the longitudinal progression of depressive symptoms among individuals diagnosed with…
Ocse, Italia prima in Ue per aspettativa di vita
84,1 anni. Malattie cardiovascolari e cancro prime cause di morte
>>>ANSA/ Shock in Europa, gene a rischio cancro in una banca danese del seme
Quasi 200 bebè nati negli anni dallo sperma del donatore. Alcuni sono già morti
In Europa nati 200 bebè da un donatore di sperma a rischio cancro, alcuni sono morti
Il caso denunciato in Danimarca. Ad alcuni piccoli è stato poi diagnosticato il male
Surgical and oncological outcomes of right hemicolectomy with complete mesocolic excision in the treatment of right colon cancer: study protocol for a single-centre retrospective cohort study
Introduction
Complete mesocolic excision (CME) with central vascular ligation (CVL) has been proposed as an oncologically superior surgical technique for right-sided colon cancer, mirroring the impact of total mesorectal excision (TME) in rectal cancer. While promising results have been reported, e…
Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol
Introduction
Polysubstance use (PSU), particularly opioid-involved and stimulant-involved PSU, is a growing issue in the USA. PSU increases the risk of negative health consequences, including infectious diseases, worsening physical and mental health conditions, and overdose-related deaths. These co…
Effect of peri-interventional music on postictal agitation in electroconvulsive therapy patients (MUSE): protocol for an open-label multicentre randomised controlled trial in the Netherlands
Introduction
Postictal agitation (PIA) is a common adverse effect following electroconvulsive therapy (ECT). Current pharmacological treatments for PIA have undesirable side effects, and interventions to prevent PIA are unsatisfactory. The aim of this study is to assess the effect of peri-intervent…
Efficacy and moderators of cognitive behavioural therapy versus interpersonal psychotherapy for adult depression: study protocol of a systematic review and individual participant data meta-analysis
Introduction
Cognitive behavioural therapy (CBT) and interpersonal psychotherapy (IPT) are both efficacious treatments for depression, but it is less clear how both compare on outcome domains other than depression and in the longer term. Moreover, it is unclear which of these two psychotherapies wo…
Intelligent voice-interactive tailored communication system (ScreenTalk) to improve colorectal cancer screening uptake among first-degree relatives of colorectal cancer patients: study protocol for a cluster-randomised type I hybrid effectiveness-implementation trial
Introduction
First-degree relatives of colorectal cancer (CRC) patients have a twofold to fourfold increased risk of CRC. Tailored communication interventions have shown efficacy in improving their risk awareness and screening participation. While computer-based tailoring systems offer convenience,…
Media, 200 bebè nati in Europa da un donatore di sperma a rischio cancro
Il caso denunciato in Danimarca. Ad alcuni piccoli è stato poi diagnosticato il male
[Articles] Artifical intelligence-powered delta-NIHSS-based model for predicting recurrence, disability and mortality after acute ischaemic strokes (DISCO): a modelling study
The DISCO model, incorporating 23 clinical variables, demonstrates high accuracy, robustness, clinical accessibility, and explainability in predicting post-stroke outcomes. The predictive strength of delta-NIHSS(admission-discharge) provides mechanistic insights into stroke outcomes and could poten…
Machine learning-driven health profiling and multidimensional trajectory analysis in first-ever ischaemic stroke: protocol for a multicentre cross-sectional and prospective longitudinal study
Background
Ischaemic stroke, the most prevalent stroke subtype, imposes a significant long-term disease burden. However, patients with first-ever stroke exhibit substantial individual variability in poststroke health trajectories, manifesting heterogeneous clinical presentations. We therefore start…
Non-pharmacological and psychosocial interventions for comorbid hypertension and depression: a scoping review
Objectives
Hypertension and depression frequently co-occur, complicating patient management and worsening outcomes. This scoping review aims to systematically map non-pharmacological interventions for managing comorbid hypertension and depression, providing insights into current practices and guidi…
