A Review of Diverticulitis—Reply
In Reply We thank Dr Ceelen for his Letter in response to our Review of diverticulitis. As clearly stated in our Review, the pathophysiology of diverticular disease is incompletely understood and indeed multifactorial. The principles of the law of Laplace (P = T/R) for a cylindrical structure provi…
[Articles] Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatment
Our qualitative findings suggests that psilocybin treatment, when administered with standardised preparation and treatment support, may offer a meaningful therapeutic opportunity for Patients with PTSD. Future work should include larger controlled studies and use mixed methods to explore how sympto…
Più Selenio e meno cancro alla prostata
Tumore prostata – Un’ampia meta-analisi mostra che livelli più alti di selenio riducono l’11% il rischio di tumore della prostata. Scopri risultati, dosaggi efficaci e implicazioni cliniche.
Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota
Background
The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn’s disease (CD) and beneficial to UC. However, the mechanisms underlying these opposite effects remain unclear.
…
Reassessing the prophylactic effect of clip closure to prevent delayed rebleeding after colorectal endoscopic submucosal dissection
We read with great interest the recent EPOC trial by Miyakawa et al, published in Gut, investigating the efficacy of prophylactic clip closure following colorectal endoscopic submucosal dissection (ESD). The authors deserve recognition and appreciation for conducting a well-designed, multicentre ra…
Behavioural and social drivers of immunisation among zero dose children in pastoralist communities of Ethiopia: a qualitative study
Background
Immunisation is one of the most valuable, impactful and cost-effective public health interventions which delivers positive health, social and economic benefits. Globally, 4 million deaths worldwide are prevented by childhood vaccination every year. In Ethiopia, despite huge progress bein…
NCCN Guidelines Navigator: biblioteca di linee guida sul cancro
OncologiaIl National Comprehensive Cancer Network (NCCN) amplia la biblioteca interattiva di linee guida per la cura del cancro basate su prove e...
NCCN: linee guida sul cancro al seno
Cancro al senoIl panorama del trattamento del cancro al seno invasivo in stadio precoce e metastatico è in costante evoluzione. Nella versione 2025...
A Torino il riconoscimento di Città Compassionevole
Progetto delle fondazioni Faro e per la Ricerca sul Cancro
Value of 24- to 48-Hour Infarct Volume as a Surrogate for Clinical Outcome in Late-Window Thrombectomy May be Limited: A Post Hoc Analysis of the AURORA Collaboration
Stroke, Ahead of Print. BACKGROUND:The utility of 24- to 48-hour follow-up infarct volume (FIV) as a surrogate outcome in late time-window acute ischemic stroke is unclear. We aimed to determine associations of 24- to 48-hour FIV and clinical outcome in patients presenting >6 hours from last known …
[Articles] Effect of subcutaneous lidocaine–hydroxypropyl-β-cyclodextrin (HP-β-CD) on quality of life in patients with post-COVID condition: a 36-week observational interrupted time series study
Subcutaneous lidocaine–HP-β-CD was associated with significantly improved quality of life and symptom burden in patients with post–COVID. This home-administered intervention offers a scalable and potentially disease-modifying approach for a disabling condition with no approved treatment to date.
Esophageal Hypervigilance and Anxiety Predict Post-Treatment Outcomes in Achalasia
Achalasia is a rare esophageal motility disorder characterized by symptoms of dysphagia, regurgitation, and chest pain, which negatively impact esophageal-specific quality of life (E-QOL).1,2 Primary treatment approaches include pneumatic dilation, per-oral endoscopic myotomy, and laparoscopic Hell…
CMAJ: nuove linee guida sulla prevenzione dell’HIV prima e dopo l’esposizione
HIVSono ora disponibili trattamenti pre-esposizione multipla (PrEP) e post-esposizione (PEP) per prevenire l’infezione da HIV....
[Articles] Efficacy of a school-based, universal prevention programme for depression and anxiety in adolescents (OurFutures Mental Health): a two-arm cluster-randomised controlled trial
OurFutures Mental Health may be an efficacious intervention to improve mental health knowledge and prevent anxiety symptoms among adolescents in the short-term. Limitations of this trial include high participant attrition and withdrawal of several schools post-randomisation, limiting generalisabili…
[Articles] Liver regeneration-associated machine learning architecture integrating time-phased predictions for post-hepatectomy liver failure
The PILOT architecture integrates liver regeneration-associated biomarkers with time-phased data to accurately predict PHLF within the first 6 h postoperatively. Based on consistency analysis of predictions of PILOT-Pre and PILOT-Intra models, this framework enables early risk stratification, there…
[Articles] Sertraline to reduce recidivism in impulsive violent offenders (ReINVEST): a randomised double blind clinical trial
Sertraline did not significantly reduce the risk of violent reoffending compared with placebo. Post-hoc analyses suggested a possible selective effect on domestic violence offending.
