Risultati per: Nota 13 AIFA - Guida pratica

Per le forme con mutazione dei geni Brca. Cala del 42% il rischio recidiva

Comunicato del 15/11/2023 n°57

Prevista l’eliminazione della figura del direttore generale

Fra questi il Semaglutide, usato anche per dimagrire

Circulation, Volume 148, Issue Suppl_1, Page A12591-A12591, November 6, 2023. Introduction:Acute myocardial infarction (AMI) is the most prevalent cause of mortality and morbidity in patients with type 2 diabetes mellitus (T2DM). However, strict blood glucose control does not always prevent the development and progression of AMI.Aims:Therefore, the present study aimed to explore potential new biomarkers associated with the occurrence of AMI in T2DM patients.Methods:A total of 82 participants were recruited, including the control group (n=28), T2DM without AMI group (T2DM, n=30) and T2DM with initial AMI group (T2DM+AMI, n=24). The untargeted metabolomics using LC-MS analysis was performed to evaluate the changes in serum metabolites. Then, candidate metabolites were determined using ELISA method in the validation study (n=126/T2DM group, n=122/T2DM+AMI group).Results:The results showed that 146 differential serum metabolites were identified among the control, T2DM and T2DM+AMI, Moreover, 16 differentially-expressed metabolites were significantly altered in T2DM+AMI compared to T2DM. Furthermore, three candidate differential metabolites, 12,13-diHOME, noradrenaline (NE) and estrone sulfate (ES), were selected for validation study. Serum levels of 12,13-diHOME and NE in T2DM+AMI were significantly higher than those in T2DM. Multivariate logistic analyses showed that 12,13-diHOME (OR, 1.491; 95% CI, 1.230-1.807,P