Ricerca del Cro di Aviano pubblicata sul Journal of Pathology
Risultati per: Studio REDUCE-IT e appropriatezza prescrittiva degli acidi grassi omega-3
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Uno studio per superare la farmaco resistenza nel tumore al seno
Ricerca del Cro di Aviano pubblicata sul Journal of Pathology
Intracerebral Hemorrhage: Keep It Simple
Stroke, Ahead of Print. The quotation, attributed to Confucius many centuries ago, in our opinion, applies to the evolving story of defining a primary surgical treatment for spontaneous intracerebral hemorrhage. The precise quote is: “Keep it simple and focus on what matters. Don’t let yourself be overwhelmed.”1The evidence from multiple trials on intracerebral hemorrhage regarding mortality benefit and potential functional benefit directs us toward the simple task of evacuating the clot, similar to our prime focus on opening the artery in ischemic stroke. We need not be overwhelmed by questions about adjustments to patient selection, comparative techniques, and precision timing, for which we do not have conclusive data. We review the consensus results from the recent MISTIE trial (Minimally Invasive Surgery Plus Alteplase in ICH Evacuation) and ENRICH trial (Early Minimally Invasive Removal of Intracerebral Hemorrhage) and articulate remaining questions where further evidence is needed to challenge equipoise and define future practice.
Observations from ID and Beyond: Brave New Name — How PCP Became PJP and Why It Matters
Dr. Paul Sax explains how “PCP” became “PJP” for Pneumocystis jirovecii pneumonia in HIV and ID Observations.
Feasibility of a theory-based intervention towards benzodiazepine deprescribing in Belgian nursing homes: protocol of the END-IT NH cluster-randomised controlled trial
Introduction
Despite several calls to deprescribe benzodiazepine receptor agonists (BZRA) in older adults, their use among nursing home residents (NHRs) remains high. Therefore, we developed an intervention targeting general practitioners’ and healthcare professionals’ behaviours regarding BZRA deprescribing in nursing homes (NHs): The END-IT NH (bENzodiazepines Deprescribing InTerventions Nursing homes) 6-component intervention. Before moving on to a large-scale effectiveness and cost-effectiveness evaluation, this feasibility study aims at: (1) assessing the feasibility of the intervention implementation in NHs, (2) assessing the feasibility of conducting a larger-scale evaluation, in terms of recruitment and data collection and (3) conducting an exploratory cost-effectiveness evaluation.
Methods and analysis
We will conduct a cluster-randomised controlled trial in a sample of 6 NHs, with 10–15 NHRs included per NHs. Four NHs will be randomised into the intervention group, and two NHs will deliver usual care (control group). Data collection will occur at baseline, 3, and 6 months (study end). We will collect information to explore implementation fidelity, mechanisms of impact and contextual factors at patient-level, NH-level and healthcare professional-level, using both quantitative and qualitative measures. The feasibility of the study conduction will be assessed by measuring recruitment and attrition rates and completeness of data collection. An exploratory cost-effectiveness evaluation will be conducted based on quality of life and healthcare use and cost data.
Ethics and dissemination
This study protocol received approval from the ethical committee of CHU UCL Namur on the 20 June 2023. All data are confidential and will be anonymised prior to analysis. De-identified data will be shared on a data depository with a 2-year embargo. The results of the study will be disseminated through a scientific paper and will be communicated to local stakeholders and policymakers through a local symposium.
Trial registration number
NCT05929443.
Therapy for Hodgkin’s Lymphoma — Can It Get Any Better?
New England Journal of Medicine, Volume 391, Issue 15, Page 1452-1454, October 17, 2024.
Studio con IA per predire fibrillazioni nelle donne e ictus
Cardiologia, al via ad Ancona guidato da professor Dello Russo
Confirmatory Trials of Accelerated Approval Drugs — Will Imposing Fines Reduce Delays?
New England Journal of Medicine, Ahead of Print.
Da una tesi di laurea studio contro rischio mortalità per Covid
Analisi condotta nel Policlinico di Palermo e pubblicata su Jcm
La nocciola possibile antitumorale, studio su cellule del fegato
Condotto dall’Enea. Biomolecole ne inibiscono la proliferazione
Does Screening for Atrial Fibrillation Reduce Stroke Risk?
A 14-day monitor detected more atrial fibrillation but did not affect hospitalization rates for stroke or hemorrhage.
Parkinson, un nuovo modello per lo studio della forma giovanile
Sono circa 10 milioni i malati nel mondo, 250mila in Italia
Parkinson, un nuovo modello per lo studio della forma giovanile
Sono circa 10 milioni i malati nel mondo, 250mila in Italia
In patients receiving invasive ventilation, PPIs reduce upper GI bleeding but did not affect mortality at 90 d
Annals of Internal Medicine, Ahead of Print.
In advanced CKD, ACEis or ARBs reduce kidney failure vs. placebo or non-RAAS inhibitors at 34 mo
Annals of Internal Medicine, Ahead of Print.
In patients receiving invasive ventilation, PPIs reduce upper GI bleeding but did not affect mortality at 90 d
Annals of Internal Medicine, Ahead of Print.