Risultati per: Valutazione e gestione del Melanoma

This consensus statement provides consensus recommendations on optimal screening practices and prebiopsy diagnostic, postbiopsy diagnostic, and prognostic assessment of cutaneous melanoma.

Melanoma mortality has declined over the past decade, largely due to availability of dramatically more effective treatments of advanced disease, but melanoma remains an important public health problem due to a persistent significant mortality risk as well as morbidity and cost. In this issue, Kashani-Sabet et al report early detection and prognostic assessment recommendations of a large group of experts using a modified Delphi approach. We consider these recommendations from 3 perspectives: the role of risk stratification, the role of gene expression profiling (GEP), and the hierarchy of evidence as it pertains to public health.

This cohort study examines the association between habitual diet and response to treatment with immune checkpoint blockade among patients with advanced melanoma.

Studio Moderna e Merck,sfrutta tecnologia a mRNA usata per Covid

To the Editor We read with tremendous enthusiasm the original investigation by Dr Adamson and colleagues demonstrating the prominence of high diagnostic scrutiny in melanoma incidence and the necessity to take seriously the role it plays in melanoma mortality. What intrigued us is the study’s conclusion that UV radiation exposure has a weak association with melanoma incidence in the US, shattering the long-standing perception of UV radiation as a formidable risk factor. If the conclusion holds true, it will alleviate the unease to some extent and downsize the magnitude of risk factors, among which UV radiation has been the most widely accepted and biggest culprit for melanoma.

In Reply We appreciate the tremendous enthusiasm with which Drs He and Huang read our article highlighting the weak association between proxies for UV radiation exposure and melanoma incidence across US counties. Although this revelation may be surprising to some readers and could shatter long-standing perceptions for others, it is not a new finding. The meta-analytic relative risk for the strongest UV-related risk factor—sunburn history—is only 2.0. This relatively weak association is not recognized by the wider public because sun exposure and its association with melanoma are too often (and inappropriately) compared with smoking and lung cancer (relative risk, 10.0-20.0). Although UV radiation exposure may be a modifiable risk factor for melanoma, it is certainly not formidable.

This scoping review describes strategies to improve adherence to self-management practices in randomized clinical trials of people at high risk of melanoma.

This JAMA Patient Page describes melanoma, its risk factors, diagnosis, treatment, and prognosis.