Risultati per: Carcinoma cutaneo a cellule squamose

To the Editor We read with great interest the cohort study by Kim and colleagues and appreciate the authors’ efforts to determine the adverse prognostic association of high-level serum antidrug antibody (ADA) against atezolizumab in patients with advanced hepatocellular carcinoma (HCC) treated with atezolizumab and bevacizumab. We have 3 concerns regarding the interpretation of the findings and hope that the authors would consider them.

This phase 2 randomized clinical trial evaluates whether the addition of vistusertib to weekly paclitaxel improves clinical outcomes in patients with platinum-resistant ovarian high-grade serous carcinoma.

Objectives
To compare the prognostic values of three lymph node staging systems in renal cell carcinoma (RCC), including the number of positive lymph nodes (NPLN), lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS).

Design
A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) database.

Setting and participants
1904 patients with pathological N1 RCC, diagnosed from 2004 to 2015 and underwent nephrectomy combined with lymph node dissection, were identified from the SEER database.

Primary outcome measure
The primary outcome of this study was overall survival (OS). Restricted cubic spline functions and multivariable Cox regression analyses were employed to characterise the associations of OS with NPLN, LNR and LODDS, respectively.

Results
Data of 1904 eligible RCC patients were extracted from the SEER database. The mortality risks of RCC patients increased with the increasing of NPLN, LNR and LODDS. NPLN (NPLN3 vs NPLN1, HR 1.22, 95% CI 1.05 to 1.43, p=0.001), LNR (LNR3 vs LNR1, HR 1.46, 95% CI 1.28 to 1.67, p

Scoperta apre la strada a farmaci contro le neoplasie

Gastric cancer (GC) is a major cancer type characterized by high heterogeneity in both tumor cells and the tumor immune microenvironment (TIME). One intractable GC subtype is gastric signet-ring cell carcinoma (GSRCC), which is associated with poor prognosis. However, it remains unclear what the GSRCC TIME characteristics are and how these characteristics may contribute to clinical outcomes.

Lo studio dei ricercatori dell’Ifom di Milano e del Cnr-Igm di Pavia, appena pubblicato su Nature Cell Biology, dimostra che il coronavirus viola i sistemi delle cellule, ne danneggia il Dna e impedisce di ripararlo

Lo studio dei ricercatori dell’Ifom di Milano e del Cnr-Igm di Pavia, appena pubblicato su Nature Cell Biology, dimostra che il coronavirus viola i sistemi delle cellule, ne danneggia il Dna e impedisce di ripararlo

Despite recent progress, long-term survival remains low for hepatocellular carcinoma (HCC). The most effective HCC therapies target the tumor immune microenvironment (TIME), and there are almost no therapies that directly target tumor cells. Here, we investigated the regulation and function of tumor cell-expressed YAP and TAZ in HCC.

The therapeutic effect of immune checkpoint inhibitors (ICIs) is poor in hepatocellular carcinoma (HCC) and varies greatly among individuals. Schlafen (SLFN) family members have important functions in immunity and oncology, but their roles in cancer immunobiology remain unclear. Herein, we aimed to investigate the role of the SLFN family in immune responses against HCC.

Objectives
The present study aimed to develop and validate nomograms to predict the survival of patients with breast invasive micropapillary carcinoma (IMPC) to aid objective decision-making.

Design
Prognostic factors were identified using Cox proportional hazards regression analyses and used to construct nomograms to predict overall survival (OS) and breast cancer-specific survival (BCSS) at 3 and 5 years. Kaplan-Meier analysis, calibration curves, the area under the curve (AUC) and the concordance index (C-index) evaluated the nomograms’ performance. Decision curve analysis (DCA), integrated discrimination improvement (IDI) and net reclassification improvement (NRI) were used to compare the nomograms with the American Joint Committee on Cancer (AJCC) staging system.

Setting
Patient data were collected from the Surveillance, Epidemiology, and End Results (SEER) database. This database holds data related to the incidence of cancer acquired from 18 population-based cancer registries in the US.

Participants
We ruled out 1893 patients and allowed the incorporation of 1340 patients into the present study.

Results
The C-index of the AJCC8 stage was lower than that of the OS nomogram (0.670 vs 0.766) and the OS nomograms had higher AUCs than the AJCC8 stage (3 years: 0.839 vs 0.735, 5 years: 0.787 vs 0.658). On calibration plots, the predicted and actual outcomes agreed well, and DCA revealed that the nomograms had better clinical utility compared with the conventional prognosis tool. In the training cohort, the NRI for OS was 0.227, and for BCSS was 0.182, while the IDI for OS was 0.070, and for BCSS was 0.078 (both p

Inaugurato nei giorni dei primi lockdown (marzo 2020) poco fuori Amsterdam, ecco come vengono prodotti gli anti tumorali biologici nel grande stabilimento costato 135 milioni di euro

Tecniche imaging per un nuovo metodo identificazione neoplasia