Primary Palliative Care for Emergency Medicine

This cluster randomized clinical trial compares the effect of a multicomponent intervention to initiate palliative care in the emergency department during a preintervention period vs a postintervention period on hospital admission, subsequent health care use, and survival in older adults with serious, life-limiting illness.

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Febbraio 2025

Expanding Palliative Care Access—Bridging Gaps in Diverse Clinical Settings

Palliative care has become standard in many inpatient settings, with about three-quarters of US hospitals currently offering such services. Although early integration of palliative care can yield substantial benefits for patients and their caregivers (eg, enhanced quality of life, psychological well-being, improved coping), the optimal timing and best clinical settings for initiating palliative care are not yet established.

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Febbraio 2025

Underused Palliative Care Could Aid Stroke Survivors

Every year in the US, 800 000 people experience strokes, and although most survive, current treatment plans fail to adequately address their physical, emotional, psychosocial, and spiritual distress, according to a new scientific statement from the American Heart Association. Palliative care could aid in the quality of life for both patients and their families by helping during all stages of poststroke care, including adapting to functional changes, navigating complex health care systems, and preparing for death when necessary. However, such care is often underused.

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Febbraio 2025

Quest for HBV functional cure: what have we learnt from silencing RNAs?

The remarkable success of direct-acting antivirals in curing hepatitis C led to concerted efforts in developing a cure for hepatitis B. Unlike hepatitis C, it is accepted that a sterilising cure is not feasible in the foreseeable future. Instead, functional cure defined as hepatitis B surface antigen (HBsAg) loss (below detection) and HBV DNA suppression (below quantification) sustained for at least 24 weeks after completion of treatment has been embraced.1 Nucleos(t)ide analogues (NA) currently in use, entecavir and tenofovir, are highly effective in maintaining suppression of HBV DNA replication and yields substantial clinical benefits including reduced rates of cirrhosis and hepatocellular carcinoma, but HBsAg loss remains elusive. Yet, if a functional cure is achieved, the benefits are multiple, with further reductions in the risk for liver-related outcomes,2 elimination of the need for long-term monitoring and NA treatment and addressing the stigma associated with HBsAg-positivity. Strategies…

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Febbraio 2025