Risultati per: Prima terapia farmacologica per l’apnea notturna (OSAS)

Circulation, Volume 150, Issue Suppl_1, Page A4144386-A4144386, November 12, 2024. Background:Previous literature suggests that Obstructive sleep apnea (OSA) increases atrial fibrillation (AF) recurrence after catheter ablation, but its impact on atrial remodeling has not been investigated.Objective:The study assesses the impact of OSA and continuous positive airway pressure (CPAP) on atrial remodeling, AF burden, arrhythmia recurrence, QoL improvement.Methods:The study population consists of patients with persistent AF with late-gadolinium enhancement (LGE) MRI before and after undergoing catheter ablation from the DECAAF II trial. We compared a subgroup with OSA with the rest of the cohort. The three study outcomes were measured with the following: arrhythmia recurrence and AF Burden based on single-lead smartphone-based daily electrocardiogram (ECG) strips, and SF36 questionnaires (baseline, 3-month, 12 month). Survival analysis of arrhythmia recurrence was performed using cox regression analysis, controlling for confounders.Results:The study population consists of 815 patients. We compared 84 OSA patients with the remaining 731 non-OSA population. Amongst OSA patients 29 patients were treated with CPAP. Baseline characteristics including baseline fibrosis (18.8 vs 18.86; p=0.9426), left atrial volume index (LAVI) (62.4 mm3vs 62.6 mm3p=0.95), and comorbidities were not different between OSA and non-OSA patients except for body mass index (30.9 vs 35.1; p

Circulation, Volume 150, Issue Suppl_1, Page A4144926-A4144926, November 12, 2024. Background:Sleep apnea is characterized by cessation of breathing during sleep. It is often prevalent among patients with cardiovascular disorders. Ticagrelor, an anti-platelet drug, can have significant implications on the health of a patient. It is suspected to have potential impacts on sleep including sleep apnea. However, the extent of the association between ticagrelor and sleep apnea is unclear.Hypothesis:This meta-analysis evaluates the association between ticagrelor and the association of sleep apnea compared to placebo.Method:We systematically searched for relevant articles published until March 2024, on PubMed, Google Scholar and Embase. Odds ratios (OR) were pooled using the random-effects DerSimonian-Laird model, and a p-value of

Circulation, Volume 150, Issue Suppl_1, Page A4144389-A4144389, November 12, 2024. Background:Obstructive sleep apnea (OSA) may influence the outcomes of catheter ablation in atrial fibrillation (AF) patients, but its impact at different stages of AF is not well understood.Objective:This study aims to evaluate whether OSA influences catheter ablation outcomes differently in patients with paroxysmal AF compared to those with persistent AF.Methods:We included AF patients with and without obstructive sleep apnea (OSA) in a late gadolinium enhancement (LGE) MRI database of patients who underwent catheter ablation. Our study population was stratified based on the type of AF: paroxysmal or persistent. Patients were followed for 24 months post-ablation, with a 3-month blanking period. To analyze time-to-AF recurrence, we used Kaplan-Meier curve along with the log-rank test to compare recurrence rates between patients with and without OSA in both AF types. Additionally, we used Cox regression analysis to adjust for potential confounders.Results:324 patients with paroxysmal AF (mean age: 64.5) and 512 patients with persistent AF (mean age: 65.2) were included. The left atrial (LA) volume was similar between OSA and non-OSA patients in both the paroxysmal AF cohort (83.1 mm3 vs. 83.6 mm3; p=0.73) and the persistent AF cohort (115 mm3 vs. 119 mm3; p=0.37). Patients with OSA exhibited a higher prevalence of comorbidities, including congestive heart failure (CHF), coronary artery disease, obesity, and diabetes, compared to non-OSA patients (p

Tumore del sangue che in Italia colpisce 860 persone ogni anno

New England Journal of Medicine, Volume 391, Issue 15, Page 1464-1464, October 17, 2024.

I risultati del progetto Iss “Veterani in Sella”

I risultati del progetto Iss “Veterani in Sella”

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Endocrinologi, troppi timori, non si spiegano bene i vantaggi

In aumento, un terzo dei pazienti riceve diagnosi dopo 5 anni