Studio italiano, la chiave è in una particolare trasformazione delle cellule
Risultati per: Scoperto nuovo biomarker per il cancro al colon-retto
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Colon Cancer Screening, Surveillance, and Treatment: Novel AI driving strategies in the management of colon lesions
Colonoscopy, a crucial procedure for detecting and removing colorectal polyps, has seen transformative advancements through the integration of Artificial Intelligence (AI), specifically in Computer-Aided Detection (CADe) and Diagnosis (CADx). These tools enhance real-time detection and characterization of lesions, potentially reducing human error, and standardizing the quality of colonoscopy across endoscopists. CADe has proven effective in increasing adenoma detection rate, potentially reducing long-term colorectal cancer incidence.
Laureandi in Medicina scendono in campo per la prevenzione. Il video 'Screening a catena' contro il tumore del colon retto
Iniziativa all’Università Politecnica delle Marche
Lo yogurt potrebbe ridurre il cancro al colon
Biomarker-Directed Radiotherapy in Breast Cancer
This narrative review explores the potential of biomarker-directed personalized radiotherapy approaches.
Cardiac Biomarker Testing in US Emergency Departments
This cross-sectional study identifies variables in cardiac biomarker testing and their association with acute coronary syndrome incidence among adults visiting the emergency department.
Genetic Ancestry–Based Differences in Biomarker-Based Eligibility for Precision Oncology Therapies
This cohort study examines if the approval of precision oncology therapies has benefited patients with cancer from various ancestral backgrounds equally over time.
Cancro al seno avanzato: diagnosi e trattamento
Cancro del pancreas, verso un vaccino che previene le recidive
Ai primi test porta sviluppo di cellule immunitarie anti-tumore
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antibiotics while maintaining treatment safety measured by 28-day all-cause mortality.
Nuova speranza per il trattamento del cancro colorettale
Accordo tra Aiom e Fondazione Airc per la prevenzione del cancro
Si rafforza collaborazione tra Istituti, verso progetti comuni
Un esame del sangue identifica il cancro al pancreas
Mangiare yogurt può ridurre il rischio di specifici tumori del colon-retto
Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-directed, signal-seeking, umbrella, clinical trial for recurrent IDH mutant, grade 2/3 glioma
Introduction
All grade 2/3 gliomas are incurable and at the time of inevitable relapse, patients have significant unmet needs with few effective treatments. This study aims to improve outcomes by molecular profiling of patients at relapse, then matching them with the best available drug based on their molecular profile, maximising the chances of patient benefit while simultaneously testing multiple novel drugs.
Methods and analysis
Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2) will be an international, phase 2, multicentre, open-label, biomarker-directed, umbrella clinical trial for recurrent isocitrate dehydrogenase mutant, histologically grade 2/3 gliomas. Investigational treatment will be assigned based on molecular profiling of contemporaneous tissue obtained at disease relapse using next-generation sequencing. LUMOS-2 will begin with three therapeutic treatment arms: paxalisib, cadonilimab and selinexor. Patient molecular profiles will be assessed by an expert, multidisciplinary Molecular Tumour Advisory Panel. Patients whose molecular profile is considered suitable for a targeted agent like paxalisib will be allocated to that arm, others will be randomised to the available arms of the trial. The primary endpoint is progression-free survival at 6 months. Secondary objectives include assessment of overall survival, response rate, safety and quality of life measures. Two additional therapeutic arms are currently in development.
Ethics and dissemination
Central ethics approval was obtained from the Sydney Local Health District Ethics Review Committee, Royal Prince Alfred Hospital Zone, Sydney, Australia (Approval: 2022/ETH02230). Other clinical sites will provide oversight through local governance processes, including obtaining informed consent from suitable participants. A report describing the results of the study will be submitted to international meetings and peer-reviewed journals.
Trial registration number
ACTRN12623000096651.
Arte-terapia per i bimbi con cancro all'associazione Peter Pan
L’organizzazione accoglie a Roma chi viene da fuori per le cure