Una meta-analisi internazionale, condotta dai ricercatori dell’Università Cattolica Giovanni Paolo […]
Search Results for: Utilizzo degli stent-retriever nell’ictus ischemico acuto
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Correction to: Randomized Study Comparing First-Line Dual Versus Single-Stent Retriever Technique: TWIN2WIN
Stroke, Volume 56, Issue 4, Page e129-e129, April 1, 2025.
Diagnosi precoce dell'ictus, a Chieti c'è la Risonanza portatile
Prima in Italia, finanziata dal ministero della Salute
Linee guida sul trattamento dell’emicrania episodica acuta
Le nuove linee guida sul trattamento dell’emicrania episodica acuta forniscono […]
I consumatori di cannabis corrono un rischio sostanzialmente più elevato di infarto
Le persone che usano cannabis hanno maggiori probabilità di soffrire […]
“Prevenzione Insieme!”, progetto in Valle d'Aosta sull'ictus
Sono previste sei giornate di screening gratuiti
Covered Stent Treatment for Sinus Venosus Atrial Septal Defects: Early Promise and Potential Limitations
Circulation, Volume 151, Issue 11, Page 757-759, March 18, 2025.
Assessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study
Objectives
Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge. This study aims to assess the effectiveness of four established risk scores in predicting short-term MACE after primary PCI.
Design
Prospective observational study.
Setting
The National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Participants
We enrolled a cohort of consecutive adult patients diagnosed with ST-elevation myocardial infarction undergoing primary PCI over a 6-month period, from 1 January 2022 to 30 June 2022.
Outcome measures
All the patients were followed at intervals of 3 months up to 12 months, and MACE events were recorded. Thrombolysis in Myocardial Infarction (TIMI), Primary Angioplasty in Myocardial Infarction (PAMI), Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) and Global Registry of Acute Coronary Events (GRACE) scores were obtained.
Results
A total of 2839 patients (79.3% male, mean age 55.6±11.2 years) were included. Over a median follow-up of 244 days, the composite MACE rate was 18.4% (521). All-cause mortality was 13.5% (384), reinfarction requiring revascularisation was 4.3% (121), heart failure-related rehospitalisation was 2.7% (76), stent thrombosis occurred in 5.6% (160) and cerebrovascular accident events were documented in 1% (28). The area under the curve for TIMI, PAMI, CADILLAC and GRACE scores was 0.682 (95% CI 0.655 to 0.709), 0.688 (95% CI 0.663 to 0.713), 0.686 (95% CI 0.66 to 0.711) and 0.695 (95% CI 0.669 to 0.72), respectively, for the prediction of MACE. On multivariable Cox regression, high-risk categories based on GRACE score were independent predictors of MACE with adjusted HR of 1.88 (95% CI 1.28 to 2.77; p=0.001).
Conclusions
A significant proportion of patients experienced short-term MACE after primary PCI. While none of the assessed scores demonstrated significant predictive power, the GRACE score exhibited comparatively better predictive ability than the TIMI, PAMI and CADILLAC scores.
Trattamento dell'ictus: premiata neurologia Ast di Ascoli
‘Stato gold’ nell’ambito del programma ‘Eso-Angels Awards
Is Anticoagulation Alone Sufficient After Caval or Iliofemoral Venous Stenting for PTS?
In a clinical trial of patients with post-thrombotic syndrome, stent patency rates were comparable with or without add-on aspirin.
Response letter to the editor
We are delighted that Fritzsche et al have expressed an interest in our randomised trial investigating the effects of endoluminal radiofrequency ablation (RFA) on survival and stent patency in cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) patients.1 2 We fully agree that plastic stents are likely to exhibit shorter patency in patients with CCA. The low patency in our small subgroup of patients treated with RFA and plastic stents (n=5) was due to the development of acute cholangitis within 2 weeks of the index procedures, requiring reintervention in three of these patients. We used plastic stents only in situations where anatomical considerations did not allow for the safe and reliable use of metal stents. We believe that this decision was necessary and fully justified in this more susceptible subset of patients. Interestingly, we observed no difference in stent patency in PDAC patients, even though almost all…
Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions
Circulation, Ahead of Print. BACKGROUND:The optimal coronary stenting technique for true left main bifurcation lesions is uncertain. EBC MAIN (European Bifurcation Club Left Main Trial) aimed to evaluate clinical outcomes of a stepwise provisional strategy compared with a systematic dual-stent approach.METHODS:EBC MAIN was a randomized, investigator-initiated, open-label, multicenter, parallel-group trial conducted across 35 hospitals in 11 European countries. A total of 467 participants undergoing percutaneous coronary intervention for unprotected true left main bifurcation lesions were randomly assigned to the stepwise provisional strategy (n=230) or an upfront dual-stent approach (n=237). The mean (SD) age was 71 (10) years and 23% of participants were women. The primary end point was a composite of major adverse cardiac events, defined as all-cause mortality, all myocardial infarction, or clinically driven target lesion revascularization. Events were adjudicated by an independent clinical events committee and all analyses were by the intention-to-treat principle.RESULTS:At 3 years, the primary end point occurred in 54 of 230 (23.5%) stepwise provisional and 70 of 237 (29.5%) dual-stent patients (hazard ratio, 0.75 [95% CI, 0.53–1.07];P=0.11). There was no significant difference in all-cause mortality (10.0% versus 13.1%) or myocardial infarction (12.2% versus 11.0%). However, target lesion revascularization was significantly lower in the stepwise provisional group (8.3% versus 15.6%; hazard ratio, 0.50 [95% CI, 0.29–0.86];P=0.013). In this population, the mean side vessel diameter by quantitative angiography was 2.9 mm, and median side vessel lesion length was 5 mm. Significant interactions were identified between the assigned bifurcation strategy and both side vessel diameter and lesion length with respect to the primary outcome (P=0.009 andP=0.005, respectively), with smaller vessels (
Abstract 80: Predictors of Procedural Outcome after Surface-Modified Flow Diverter Treatment for Intracranial Aneurysms: An Update from the INSPIRE-A Registry
Stroke, Volume 56, Issue Suppl_1, Page A80-A80, February 1, 2025. Introduction:Although flow diverters (FD) are a long-established treatment-option for brain aneurysms, the evidence of data associated with therapy success is still based on relatively small heterogeneous studies. Recent data from a large prospective registry with highly standardized, independent adjudication might provide more insights.Methods:The INSPIRE-A registry is a prospective, single arm study of brain aneurysms treated with commercially available Medtronic devices, including latest FD technology with surface modifications. The registry collects data from 70 centers in 21 countries. Results are adjudicated by an independent Imaging Core Laboratory and a Clinical Events Committee. The association of patient characteristics, aneurysm details, and procedural variables with aneurysm occlusion (Raymond–Roy occlusion classifications [RROC I]), and in-stent stenosis at 1 year follow-up (FU) were tested using multivariable logistic regression analysis.Results:786 patients were analyzed. The median age was 55 years (IQR, 46-64) and 79.6% (626) were female. Most frequently, aneurysms were in the anterior circulation (89.8 %, 706) with highest rates of ICA-Aneurysms (75.3%, 592) in the C6 (52.7%, 312/592). Median diameter and neck width of aneurysms were 7.2 mm (IQR, 5-11) and 6.5 mm (IQR, 4-10), respectively. 91.7% (719) of aneurysms were saccular. The Pipeline Flex with Shield technology (Medtronic, Irvine CA) device was deployed in 58% (456), the Pipeline Vantage with Shield technology (Medtronic, Irvine CA) device in 42% (330). Adjunctive coiling was used in 19.8% (156). At 1 year FU, RROC I was observed in 74.3% (584) of cases. In multivariable analysis, increasing age (OR, 0.97, 95% CI, 0.96-0.99; p
Abstract TMP76: Inadequate Pre-Procedure Antiplatelet Medication Use May Explain the Higher Risk of Peri-Procedural Stroke and/or Death with Carotid Stent Placement within First 7 Days after Qualifying Ischemic Event
Stroke, Volume 56, Issue Suppl_1, Page ATMP76-ATMP76, February 1, 2025. Background and Purpose:In randomized trials, carotid artery stent (CAS) may have higher risk of periprocedural risk compared with carotid endarterectomy (CEA) if performed within the first 7 days after the onset of symptoms.Methods:We analyzed the data from Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). The time interval between the most recent qualifying ischemic event and CAS/CEA procedure was divided in four strata: 1-7 days, 8-14 days, 15-30 days and >30 days. We analyzed the effect of time interval strata between most recent qualifying ischemic event and procedure and procedure type (CEA versus CAS) on peri-procedural stroke and/or death after adjusting for age, gender, symptomatic status and initial severity of stenosis (≥70% versus 30 days (CAS 7.8% versus CAE 4.3%, p=0.12), after the most recent qualifying event. In the multivariate analysis, patients who underwent CAS had higher rate of peri-procedural stroke and/or death (odds ratio [OR] 2.36, 95% confidence interval [CI] 1.25- 4.66) but timing of procedure were not associated with higher rate of peri-procedural stroke and/or death after adjustment for potential confounders. The interaction between procedure type and timing of procedure was not significant. The rate of peri-procedural stroke and/or death was significantly higher in CAS patients who received clopidogrel bolus (without 48-hour maintenance dose) among patients treated 7 days or less after the qualifying event compared with those undergoing CEA (6.6% versus 0%, p=0.012) but was not different between CAS patients who received 48 hours of clopidogrel maintenance and those undergoing CEA (0% versus 0%).Conclusions:The higher rate of peri-procedural stroke and/or death seen with CAS (compared with CEA) within the first 7 days may be attributed to factors such as inadequate pre-procedure antiplatelet medication use. The results of CAS and CEA may become comparable within the first 7 days after the qualifying ischemic event with use of newer generation P2Y12 platelet inhibitors that achieve rapid antiplatelet inhibition.
Abstract TMP84: Switching Thrombectomy Technique After Failed First Pass Improves Reperfusion Success: A Multi-Center Cohort Study Using SVIN Registry
Stroke, Volume 56, Issue Suppl_1, Page ATMP84-ATMP84, February 1, 2025. Introduction:Complete reperfusion (TICI 2c/3) with the fewest number of passes remains the target for EVT techniques, but at present, rates remain relatively low. Prior studies have demonstrated that switching techniques between passes may improve rates of reperfusion. Here we assess the efficacy of technique switching after the first pass failed reperfusion in a large multi-center cohort.Methods:All consecutive patients treated with EVT from 12 centers across the US were prospectively collected between 10/2018 – 12/2021 (SVIN Registry). Patients were included if they underwent EVT for occlusion of the M1 or ICA-T. Exclusion criteria included incomplete data. EVT technique was categorized as Stent-Retriever (SR), Contact Aspiration (CA), or a Combined Technique (CT). The primary outcome was the likelihood of achieving TICI 2c/3 with or without switching the thrombectomy technique and was determined using multivariable logistic regression adjusted for the use of balloon guide catheter, occlusion location, age, and co-morbid medical conditions.Results:Among 2,891 patients in the SVIN registry included in this analysis, the median age was 69 years [IQR, 58-80], 49.9% were female and median NIHSS was 17 [IQR, 12-22]. Occlusion location was ICA-T in 18.4% and M1 in 81.6%. As shown in Figure 1a, for patients with ICA-T occlusions, first-pass TICI 2c/3 occurred in 32.7% with SR, 23% with CA, and 31.2% with CT. As shown in Figure 1b, for patients with M1 occlusions, first-pass TICI 2c/3 occurred in 37.7% with SR, 35.9% with CA, and 35.4% with CT. Switching from CA to SR or CT for the 2nd pass was associated with increased point estimates of 2nd pass TICI 2c/3 for patients with ICA-T occlusions (27% vs 12%, second pass SR vs. second pass CA, p=0.06). In multivariable logistic regression, odds of TICI 2c/3 were significantly greater (OR 3.7, CI 95% [1.1 – 12.4]) after switching to SR or CT after a failed first pass with CA in patients with ICA-T occlusion.Conclusions:Switching from CA to SR-based techniques was associated with improvement in TICI 2c/3 reperfusion rates among patients with Internal Carotid Artery Terminus occlusions.
Abstract TMP82: First line aspiration versus stent retriever for posterior circulation stroke; A meta-analysis
Stroke, Volume 56, Issue Suppl_1, Page ATMP82-ATMP82, February 1, 2025. Introduction:Aspiration and stent retriever thrombectomy are the primary approaches for endovascular management of posterior circulation stroke. However, the optimal first-line choice of surgical technique remains unclear. This study aims to conduct a systematic review and meta-analysis comparing first-line aspiration with stent retriever thrombectomy in terms of recanalization rates, complications, and clinical outcomes.Methodology:This systematic review and meta-analysis followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Databases searched included PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov, focusing on studies comparing the efficacy and safety of first-line aspiration versus stent retriever thrombectomy for posterior circulation stroke. Data analysis was performed using RevMan version 5.4.1, with statistical significance set at p < 0.05.Result:A total of 21 studies, including 2,521 patients, were analyzed. First-line aspiration demonstrated a significant advantage in terms of successful recanalization (OR = 1.36; 95% CI: 1.04–1.76; p = 0.002) and complete recanalization (OR = 1.41; 95% CI: 0.91–2.20; p = 0.03), both favoring aspiration over the stent retriever technique. Additionally, first-line aspiration was associated with a significantly lower overall complication rate (OR = 0.58; 95% CI: 0.40–0.85; p = 0.005) and a shorter procedural time (SMD = -0.60; 95% CI: -0.81 to -0.40; p < 0.005). However, there were no statistically significant differences between the two techniques in the first pass effect (OR = 1.41; 95% CI: 0.95–2.09; p = 0.09), the need for rescue therapy (OR = 1.01; 95% CI: 0.71–1.44; p = 0.96), 90-day all-cause mortality (OR = 0.95; 95% CI: 0.71–1.27; p = 0.72), and 90-day favorable functional outcome (OR = 1.17; 95% CI: 0.97–1.41; p = 0.11).Conclusion:This meta-analysis suggests that first-line aspiration may offer advantages over stent retrievers for posterior circulation stroke, particularly in terms of recanalization success and procedural safety. However, no significant differences were observed in key clinical outcomes such as mortality and favorable recovery.