Risultati per: Case report: porpora di Schonlein-Henoch in una giovane adulta in ambulatorio di Medicina Generale

Annals of Internal Medicine, Ahead of Print.

Gli internisti: il 58% in overbooking, ma è evitabile 1 ricovero su 3

Indagine internisti, posti occupati oltre il 100%. Pazienti su Lettighe nei corridoi. Carenza cronica di medici e infermieri nell’85% delle strutture

Accordo integrativo, 8,5 milioni per Aft e sanità territoriale

New England Journal of Medicine, Volume 392, Issue 18, Page 1847-1856, May 8, 2025.

Effettuato all’Ospedale Bambino Gesù con procedura innovativa

Gimbe monitora il Pnrr Salute del primo trimestre 2025, la ‘riforma arranca’

Objectives
The primary aim of this study was to optimise colorectal cancer (CRC) screening strategies and target populations in resource-limited areas through cost-effectiveness analysis, evaluating the best screening methods and appropriate screening ages.

Design
A prospective microsimulation model was used for cost-effectiveness analysis, calibrated with real-world data.

Setting
The study was conducted in Huzhou City, Zhejiang Province, China, focusing on primary and secondary healthcare levels. Data were obtained from the Huzhou Center for Disease Control and Prevention.

Participants
The study included 418 805 local residents who participated in the Huzhou screening programme between 2020 and 2022. Inclusion criteria were individuals aged 45–100 years and residing in the local area.

Interventions
Four initial screening methods were evaluated: single-sample immunochemical faecal occult blood test (iFOBT), double-sample iFOBT, single-sample iFOBT combined with a risk assessment questionnaire and double-sample iFOBT combined with a risk assessment questionnaire. Screening frequencies included annual and biennial intervals.

Primary outcome measures
The primary outcome measure was the cost per incremental quality-adjusted life year (QALY) for different screening strategies. Also, the impact on CRC incidence, related deaths, life years saved (LYS) and QALYs was considered.

Results
The primary data were sourced from the Huzhou screening programme, which included 418 805 individuals from 2020 to 2022. All screening strategies were found to be effective, with the cost per incremental QALY being less than $1036, which is below the minimum standard for middle-income countries. The most effective screening strategy was the annual combined two-sample iFOBT and risk evaluation questionnaires. This approach led to a reduction in CRC incidence and related deaths by 2435 and 1174 cases per 100 000 individuals, respectively, and an increase in LYS by 13 903 years and QALYs by 35 564 years. The recommended ages to begin and end screening were 48 and 72 years, respectively.

Conclusions
All CRC screening strategies demonstrated effectiveness compared with non-screening, with the annual combined two-sample iFOBT and risk evaluation questionnaires emerging as the optimal approach. For additional regions, the best screening strategy can be selected based on the health outcomes and costs we have provided.

Hewa Kankanamge DV, Rubbo B, Morgan K, et al. Domestic violence perpetration, victimisation and self-poisoning in Sri Lanka: a protocol for a hospital-based case-control study. BMJ Open 2025;15:e089913. doi: 10.1136/bmjopen-2024-089913.
This article has been corrected since it was published online.
The license has been updated form CC BY NC to CC BY and the funding section has also been updated to:
This work was supported by the Elizabeth Blackwell Institute for Health Research (University of Bristol) and Wellcome Trust grant number [204813/Z/16/Z].

Stroke, Volume 56, Issue 5, Page 1339-1342, May 1, 2025. Infarct detection is critically dependent on the imaging modality that is used and the criteria for defining tissue infarction. The recent trials of large-core thrombectomy used heterogeneous imaging methods to identify patients with large ischemic cores. Moreover, the Alberta Stroke Program Early CT Score methodology was not harmonized between the trials. Consequently, the large-core trial populations were distinct. To pool the populations in a clinically meaningful way, data should be pooled by imaging modality and time window. The imaging should be re-adjudicated using standardized criteria for imaging analysis and Alberta Stroke Program Early CT Score grading. This standardized approach can be disseminated into clinical practice so that the pooled treatment effect estimates can guide real-world patient care.

Objectives
To delineate the clinical characteristics and investigate the determinants that may affect the prognosis of surgical patients with abdominal sepsis.

Design
A case-control study was nested in a cohort of surgical patients with abdominal sepsis between 2008 and 2022. We extracted patient’ medical records to execute descriptive statistical analyses. Multiple logistic regression models and subgroup analysis were employed to elucidate the risk factors of in-hospital mortality.

Setting
Two tertiary hospitals in China.

Participants
476 surgical patients diagnosed with abdominal sepsis between 2008 and 2022 were analysed.

Interventions
None.

Outcome measures
Descriptive statistics were used to examine pertinent patient information, including demographic details, laboratory findings, surgical interventions and anaesthetic records. Multivariate logistic regression was used to identify independent risk factors for in-hospital mortality. Subgroup analyses were conducted to explore the impact of specific clinical characteristics on outcomes.

Results
476 patients diagnosed with abdominal sepsis were analysed, exhibiting an in-hospital mortality rate of 7.56%. Advanced age (OR 6.77, 95% CI 2.46 to 18.66, p

Al via il nuovo progetto promosso da 1 Caffè Onlus con i medici internisti per l’umanizzazione delle cure

Progetto internisti-Caffè onlus per l’umanizzazione delle cure

New England Journal of Medicine, Volume 392, Issue 16, Page 1637-1645, April 24, 2025.

This Viewpoint discusses discordance between patient report and objectively measured walking impairment in people with peripheral artery disease without critical leg ischemia and how this discordance affects clinical care and scientific investigation.