TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental Crohn’s disease

Death receptor 3 (DR3) and its ligand, tumor necrosis factor-like ligand 1A (TL1A), regulates the balance between effector and regulatory T cells in IBD. While IL-9-secreting Th9 cells are linked to ulcerative colitis, their role in Crohn’s disease (CD) is unclear. We investigated the role of DR3 signaling in Th9 cell differentiation in mouse models of CD-like ileitis and colitis.

Leggi
Aprile 2025