Risultati per: Nuovi farmaci per il danno renale acuto (Acute kidney injury – AKI)

Circulation, Volume 151, Issue 12, Page 884-886, March 25, 2025.

Background
Delayed graft function (DGF) continues to represent one of the most frequently encountered early complications following kidney transplantation. Despite notable progress in donor and recipient pretreatment protocols, diagnostic techniques and therapeutic approaches, the incidence of DGF, along with its associated short- and long-term sequelae, has not demonstrated a significant reduction. DGF is influenced by a multitude of factors, and individuals with exposure to these risk factors exhibit a markedly increased probability of developing DGF.

Objectives
To systematically identify and evaluate risk factors associated with DGF in kidney transplant recipients.

Design
A systematic review and meta-analysis

Data sources
A comprehensive search was performed across multiple databases, including PubMed, Embase, The Cochrane Library, Web of Science, CNKI, Wanfang, VIP and SinoMed, from the inception of each database until 1 March 2024.

Primary outcome measures
OR and OR 95% CI of risk factors for DGF.

Results
The meta-analysis included 19 studies involving a total of 153 008 patients, of whom 96 596 (63.1%) developed DGF. The following risk factors for DGF were identified: prolonged cold ischaemia time (CIT) (OR=1.05, 95% CI=1.03 to 1.07, p

Objectives
To investigate the knowledge, attitudes and practices (KAP) among patients with end-stage kidney disease (ESKD) towards hyperkalaemia.

Design
A cross-sectional study.

Setting
This study was conducted between September and November 2023 at the Department of Nephrology, Shenzhen Third People’s Hospital and the Second Affiliated Hospital of Southern University of Science and Technology.

Participants
The study included 568 patients with ESKD who were undergoing haemodialysis, peritoneal dialysis or both, recruited through convenience sampling.

Primary and secondary outcome measures
This study was conducted using a self-administered questionnaire, which assessed participants’ KAP towards hyperkalaemia management. The questionnaire comprised four sections: demographic information, knowledge (13 items), attitudes (9 items) and practices (9 items), with responses evaluated using a 5-point Likert scale. A cut-off value of 70% of the total score was applied, with thresholds for sufficient knowledge, favourable attitudes and proactive practices set at 6.3, 31.5 and 31.5 points, respectively. The higher the KAP scores, the better the levels of knowledge, attitude and practice. A structural equation model (SEM) was constructed to analyse the effects of demographic characteristics on KAP dimensions. Path coefficients (standardised estimates) were used to assess the strength of relationships between variables, with coefficients >0.2 generally considered moderate effects and >0.5 strong effects.

Results
A total of 568 participants were enrolled in this study, including 369 (64.69%) males, and 249 (43.84%) have been diagnosed with ESKD for more than 5 years. The median (IQR) KAP scores of the participants were 9 (3–9) (possible range: 0–9), 34 (24–45) (possible range: 9–45) and 32 (10–45) (possible range: 9–45), respectively. SEM demonstrated that the frequency of dialysis had direct effects on knowledge (coefficient=0.113, p=0.039), education had direct effects on attitudes (coefficient=0.257, p

Objective
A multidisciplinary team is essential to providing high-quality, patient-centred care. However, its effectiveness can be either hindered or facilitated by various factors, such as the need for rapid decision-making, which may compromise patient outcomes despite individual efforts. The aim of this study is to synthesise the factors that may act as barriers and facilitators to the work of multidisciplinary teams in managing labour within acute care settings.

Design
A systematic qualitative review and meta-synthesis was conducted following the five-step methodology proposed by Sandelowski et al.

Data source
Three databases (Medline, Embase and Scopus) were systematically searched without time restrictions up to 25 May 2024.

Eligibility criteria for selecting studies
Qualitative studies exploring perspectives, experiences and other similar factors were included. These studies were assessed for methodological quality using the Critical Appraisal Skills Programme.

Data extraction and synthesis
The reviewers independently searched, screened and coded the results of the included studies. Data were synthesised using the method proposed by Thomas and Harden.

Results
Seventeen studies were included in the meta-synthesis. Four key dimensions emerged, reflecting both the barriers and the facilitators of multidisciplinary team performances: (1) organisational variables, (2) individual variables, (3) collaborative variables and (4) role variables. A total of 36 variables were identified, which could function as barriers (n=6; eg, high staff turnover), facilitators (n=6; eg, strong listening skills) or both (n=24; eg, team climate), depending on the context.

Conclusions
This meta-synthesis identifies specific barriers and facilitators and variables that can act as both. Understanding these factors enables targeted interventions to enhance the performance of multidisciplinary teams in clinical practice, particularly in acute care settings.

PROSPERO registration number
CRD42022297395.

Treatment with antibiotics alone was safe and allowed two thirds of patients to avoid appendectomy within 1 year.

Stroke, Ahead of Print. BACKGROUND:Shorter times to initiate antihypertensive and anticoagulation reversal treatments enhance their benefits in acute intracerebral hemorrhage (ICH). Improving workflows to optimize time performance metrics is strongly advocated. We aimed to evaluate the impact of direct transfer to angiography suite (DTAS) on time metrics for antihypertensive and anticoagulation reversal treatments in patients with stroke with suspected large vessel occlusion whose final diagnosis was ICH.METHODS:We conducted a single-center, retrospective, observational cohort study using prospectively collected data from patients with ICH 4 and in-hospital National Institutes of Health Stroke Scale score >10) followed either direct transfer to computed tomography (DTCT) or DTAS protocol based on angiosuite availability. We compared door-to-needle times for initiating antihypertensive (primary outcome) and anticoagulation reversal treatments between both workflows.RESULTS:Among 220 patients with ICH (mean age, 73.0±13.6 years; 131 [59.5%] male), 199 (90.5%) followed the DTCT protocol and 21 (9.5%) followed the DTAS protocol. Door-to-imaging time was shorter in the DTCT group than in the DTAS group (11 [7–17] versus 15 [12–20] minutes;P=0.013). Antihypertensive treatment was initiated in 168 (76.4%) patients, with the DTCT group having shorter door-to-needle times (20 [15–26] versus 30 [18–40] minutes;P=0.002). The anticoagulation reversal was administered to 34 (87.2%) of 39 anticoagulated patients, with the DTCT group achieving shorter door-to-needle times (28 [22–38] versus 58 [39–78] minutes;P=0.047). Time-to-event analysis showed that the DTCT group had a higher probability of initiating antihypertensive (P=0.001) and anticoagulation reversal (P=0.014) treatments sooner compared with the DTSA group.CONCLUSIONS:Patients with ICH following the DTAS workflow, without tailored actions, present longer door-to-needle times to initiate antihypertensive and anticoagulation reversal treatments compared with those following the DTCT workflow protocol.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.