Risultati per: Ipotesi sull’origine di Omicron e sua evoluzione

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Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic

GUT (Recent Issues)

Objective
Antitumour necrosis factor (TNF) drugs impair serological responses following SARS-CoV-2 vaccination. We sought to assess if a third dose of a messenger RNA (mRNA)-based vaccine substantially boosted anti-SARS-CoV-2 antibody responses and protective immunity in infliximab-treated patients with IBD.

Design
Third dose vaccine induced anti-SARS-CoV-2 spike (anti-S) receptor-binding domain (RBD) antibody responses, breakthrough SARS-CoV-2 infection, reinfection and persistent oropharyngeal carriage in patients with IBD treated with infliximab were compared with a reference cohort treated with vedolizumab from the impaCt of bioLogic therApy on saRs-cov-2 Infection and immuniTY (CLARITY) IBD study.

Results
Geometric mean (SD) anti-S RBD antibody concentrations increased in both groups following a third dose of an mRNA-based vaccine. However, concentrations were lower in patients treated with infliximab than vedolizumab, irrespective of whether their first two primary vaccine doses were ChAdOx1 nCoV-19 (1856 U/mL (5.2) vs 10 728 U/mL (3.1), p

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Gennaio 2023

'Dynamic zero-COVID policy and viral clearance during an omicron wave in Tianjin, China: a city-wide retrospective observational study

BMJ (recent)

Objective
To report how the Chinese mainland battled its first omicron wave, which happened in Tianjin, a metropolis with 14 million residents. We also sought to better understand how clinical features affected the timing of viral clearance.

Design
A retrospective study of the omicron wave in Tianjin between 8 January 2022 and 3 March 2022.

Setting
Except for the first cases on 8 January, all the omicron cases were identified through PCR mass testing in the residential communities. Residential quarantine and serial PCR mass testing were dynamically adjusted according to the trends of new cases.

Participants
All the 417 consecutive PCR-positive cases identified through mass screening of the entire city’s 14 million residents. 45.3% of the cases were male, and the median age was 37 (range 0.3–90). 389 (93%) cases had complete data for analysing the correlation between clinical features and the timing of viral clearance.

Main outcome and measure
Time to viral clearance.

Results
Tianjin initiated the ‘dynamic zero-COVID’ policy very early, that is, when daily new case number was 0.4 cases per 1 000 000 residents. Daily new cases dropped to

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Dicembre 2022
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