Risultati per: Ipotesi sull’origine di Omicron e sua evoluzione

Objective
Antitumour necrosis factor (TNF) drugs impair serological responses following SARS-CoV-2 vaccination. We sought to assess if a third dose of a messenger RNA (mRNA)-based vaccine substantially boosted anti-SARS-CoV-2 antibody responses and protective immunity in infliximab-treated patients with IBD.

Design
Third dose vaccine induced anti-SARS-CoV-2 spike (anti-S) receptor-binding domain (RBD) antibody responses, breakthrough SARS-CoV-2 infection, reinfection and persistent oropharyngeal carriage in patients with IBD treated with infliximab were compared with a reference cohort treated with vedolizumab from the impaCt of bioLogic therApy on saRs-cov-2 Infection and immuniTY (CLARITY) IBD study.

Results
Geometric mean (SD) anti-S RBD antibody concentrations increased in both groups following a third dose of an mRNA-based vaccine. However, concentrations were lower in patients treated with infliximab than vedolizumab, irrespective of whether their first two primary vaccine doses were ChAdOx1 nCoV-19 (1856 U/mL (5.2) vs 10 728 U/mL (3.1), p

Analisi su quasi 10.000 campioni da ottobre 2021 a ottobre 2022

New England Journal of Medicine, Volume 387, Issue 26, Page 2479-2481, December 2022.

Sars-Cov-2 fa meno paura ma crescono carenza medici e zoonosi

New England Journal of Medicine, Ahead of Print.

Objective
To report how the Chinese mainland battled its first omicron wave, which happened in Tianjin, a metropolis with 14 million residents. We also sought to better understand how clinical features affected the timing of viral clearance.

Design
A retrospective study of the omicron wave in Tianjin between 8 January 2022 and 3 March 2022.

Setting
Except for the first cases on 8 January, all the omicron cases were identified through PCR mass testing in the residential communities. Residential quarantine and serial PCR mass testing were dynamically adjusted according to the trends of new cases.

Participants
All the 417 consecutive PCR-positive cases identified through mass screening of the entire city’s 14 million residents. 45.3% of the cases were male, and the median age was 37 (range 0.3–90). 389 (93%) cases had complete data for analysing the correlation between clinical features and the timing of viral clearance.

Main outcome and measure
Time to viral clearance.

Results
Tianjin initiated the ‘dynamic zero-COVID’ policy very early, that is, when daily new case number was 0.4 cases per 1 000 000 residents. Daily new cases dropped to

New England Journal of Medicine, Ahead of Print.

In Reply The letter from Drs Manmadhan and Ahuja about our recent Research Letter raises 2 issues of relevance for the COVID-19 pandemic: vaccination strategies and masking.

To the Editor A recent Research Letter described the association between COVID-19 vaccine booster doses and Omicron infection in the National Basketball Association (NBA). We agree with the authors that evaluating data regarding COVID-19 vaccine booster doses is essential as new SARS-CoV-2 variants of concern emerge.

New England Journal of Medicine, Volume 387, Issue 21, November 2022.

New England Journal of Medicine, Ahead of Print.

I lost sleep—                a flock of it—           dreams extant,   alive;       breaths of blood on white sheets—                            black terns    in their eyes—

Objectives
The aim of this study was to first assess the knowledge and perception of first-year university students in Iraq about COVID-19 in general and SARS-CoV-2 latest variant of concern, and to evaluate the attitudes towards protection measures including vaccination.

Study design
A cross-sectional study was conducted among newly enrolled students at the American University of Iraq-Baghdad. Mann-Whitney U and Kruskal-Wallis tests were used to test an association between the outcomes measured on a 5-point Likert scale and the binary and the categorical independent variables, respectively. 2 test was used to test the association between nominal categorical variables, while Kendall’s -b was used for ordinal variables.

Participants
Students (n=432) were invited to fill out a survey specifically tailored to assess their knowledge, perception and attitude towards Omicron variant and COVID-19 vaccines acceptance. 363 students enrolled in various majors participated in this study.

Results
Assessment of COVID-19 knowledge and perception revealed that students still lack reliable info and data about FDA-approved treatment options (70.5%), SARS-CoV-2 variants (96.5%) and approved vaccines. Students’ attitude and practices towards recommended safety measures should be reassessed to better manage the pandemic. Adherence level was shown to be associated with the belief in its capacity to effectively manage the new variant. Interestingly, 85% of the students have received at least one dose of approved vaccine. A significant positive correlation was detected between the level of adherence to recommended precautions and the intention to take a third booster shot if proven effective.

Conclusions
Students’ reliable knowledge about COVID-19 pandemic including the various strains and approved vaccines should be improved to better manage the pandemic and set foundations for a more appropriate approach when another pandemic occurs. Special workshops should be organised to ensure that students and the public have a more trusted source of information about COVID-19.

New England Journal of Medicine, Volume 387, Issue 20, Page 1911-1912, November 2022.

New England Journal of Medicine, Ahead of Print.

To the Editor A recent study reported an increase in excess mortality during the Omicron vs Delta waves of COVID-19 in Massachusetts. The authors postulated that this finding may have been explained by Omicron’s high infectivity outweighing its lower virulence (yielding a higher mortality product) relative to Delta. However, this conclusion hinges on the following key assumptions: (1) that most excess deaths occurred in patients with (vs without) COVID-19, (2) that hospital case mix remained constant during the 2 waves, and (3) that deaths during each wave occurred independent of prior waves.