Fireflies

Today we had four babies before 9a, then two hospice discharges, an admission at 10:30 and a stat transfer to Boston. We were late rounding and I never taught bedside POCUS because my sister called in the middle of the morning (my niece just had a seizure) while an overhead Code 99 sent the team jogging to do epi and shocks. I failed to give the senior feedback and two interns cried by 5 and yet the fireflies this year are so numerous and astonishing that in the midst of all this life and death, we paused to exclaim together at last night’s glitter, like stars had fallen to earth.

Read More

Application of point-of-care ultrasound-guided tip navigation combined with visualised directional high-frequency linear array probe compression to improve the success rate of umbilical venous catheterisation in critical neonates: protocol of a multicentre randomised controlled trial in neonatal units

Introduction
Conventional umbilical venous catheterisation (UVC) relies on ‘blind’ insertion without ultrasound guidance, resulting in low success and high complication rates. While point-of-care ultrasound (POCUS)-based tip navigation and location has improved this scenario by enabling real-time visualisation of the catheter tip during UVC, challenges remain when the catheter is inadvertently inserted into an incorrect vessel. Selecting effective intervention methods to correct the catheter direction has become a key research focus. This study aims to evaluate the safety and efficacy of a novel technique combining POCUS-guided tip navigation with visualised directional high-frequency linear array probe compression (P-TN+vdHLAP C). This technique is expected to become a standardised protocol for POCUS-guided UVC, improving catheterisation success rates, minimising the frequency of insertion attempts and reducing catheterisation time.

Methods and analysis
This prospective, multicentre, single-blind, superiority, 1:1 parallel, randomised controlled trial will recruit 100 infants who have failed the initial UVC attempt using the conventional method. Participants will be randomly assigned to either the intervention group receiving P-TN+vdHLAP C or the control group receiving POCUS-guided tip location. The primary outcome measure is the success rate of UVC, defined as the proportion of catheter placements that are successfully positioned at the entrance of the inferior vena cava into the right atrium, as confirmed by POCUS. Secondary outcomes include UVC procedure time, total number of catheter insertions and postoperative monitoring indicators such as catheter tip location, incidence of complications and umbilical catheter indwelling time. Outcome measures will be assessed at seven time points: immediately after catheter placement, 12 hours, 24 hours, 48 hours and 7 days postplacement, catheter removal and discharge. Data analysis will be conducted using R (V.4.3.2).

Ethics and dissemination
The study protocol has been approved by the ethics committee of Fujian Children’s Hospital (protocol number 2024ETKLRK09019). Prior to enrolment, written informed consent will be obtained from the legal guardians of all participants by the study staff. On completion of the trial, the results will be submitted for peer-reviewed publication in an international scientific journal.

Trial registration number
ChiCTR2400090737.

Read More