Risultati per: Nelle donne lo stress danneggia la salute dell’intestino

Stroke, Volume 54, Issue Suppl_1, Page AWMP6-AWMP6, February 1, 2023. Introduction:Hyperglycemia has consistently been associated with worse outcome following an acute ischemic stroke (AIS). Recent studies have shown that a stress glucose ratio (SGR) may be a better predictor of critical illness than absolute hyperglycemia. An elevated initial stress glucose ratio (iSGR) was significantly associated with malignant cerebral edema and ICH after thrombectomy. We sought to identify genetic loci related to iSGR in a cohort of the GENISIS (Genetics of Early Neurological InStability after Ischemic Stroke) study.Methods:GENISIS is a multi-site international study that enrolled AIS patients within 6 hours of symptom onset. A sub-cohort with available initial glucose and HbA1c levels was selected. For all patients, Hg38 imputed genotypes were available. iSGR was calculated by dividing initial glucose by the estimated average glucose concentration (= 28.7 * A1c – 46.7) and normalized by log transformation for the GWAS. Association was adjusted by age, sex, baseline NIHSS, principal components and genotyping rounds. Samples were analyzed by country of origin and ethnicity using Plink2 and then meta-analyzed by ethnicity using METAL.Results:Three separate populations were identified (African-Americans n=299; European-Americans n=622; and Spanish n=625). Median age was 71 (IQR 60-80) with 46% female. Baseline NIHSS was 11 (IQR 5-16). A suggestive loci (chr13:rs9560146, p=9.88×10-8) was identified in the meta-analysis. Gene-based analyses suggested that the loci in chromosome 13 is driven byKLF5(p=0.002). In addition, rs9560146 is also associated withKLF5gene expression in brain (eQTL p=3.30×10-3; frontal cortex: Braineac).Conclusions:We demonstrated that a variant inKLF5may be associated with iSGR in a cohort of AIS patients.KLF5is induced under hypoxia conditions and interacts with HIF-1a to mediate glucose homeostasis. Recently, a pre-clinical study demonstrated that a micro RNA (miR-10b-3p) had neuroprotective effects against ischemia/reperfusion injury by targeting KLF5. Thus, investigating the genetic architecture of stress hyperglycemia may be informative and reveal variants, genes or pathways involved in ischemic brain injury. We plan to recruit a cohort for replication and sample size expansion.

Centro cefalee Ferrara, tutto esaurito per iniziativa dedicata

La Nigeria ha appena approvato un testo che riconosce il diritto alla salute della mente. Ma nel paese, e nel Continente, l’accesso alle cure è rarissimo

In grado di studiare anche polmone danneggiato da Covid

Riccardi, ‘a partire dal 30 Gennaio’

Riccardi, ‘a partire dal 30 Gennaio’

La carenza di specialisti è uno dei problemi più gravi per la sanità italiana: entro il 2030, 15 milioni di persone potrebbero trovarsi senza un medico di base. Ma cosa succederà a quei pazienti che non possono permettersi di restare senza uno specialista di riferimento, come i pazienti psichiatrici o i malati cronici?

Stroke, Volume 54, Issue 2, Page 354-363, February 1, 2023. Background:Preeclampsia increases the incidence of maternal stroke, a devastating condition that is on the rise. We investigated stroke outcome in a model of experimental preeclampsia with and without treatment with clinically relevant doses of magnesium sulfate (experimental preeclampsia+MgSO4) compared to normal late-pregnant and nonpregnant rats.Methods:Transient middle cerebral artery occlusion was used to induce focal stroke for either 1.5 or 3 hours. Infarct volume and hemorrhagic transformation were determined as measures of stroke outcome. Changes in core middle cerebral artery and collateral flow were measured by dual laser Doppler. The relationship between middle cerebral artery perfusion deficit and infarction was used as a measure of ischemic tolerance. Oxidative stress and endothelial dysfunction were measured by 3-nitrotyrosine and 8-isoprostane, in brain and serum, respectively.Results:Late-pregnant animals had robust collateral flow and greater ischemic tolerance of brain tissue, whereas experimental preeclampsia had greater infarction that was related to poor collateral flow, endothelial dysfunction, and oxidative stress. Importantly, pregnancy appeared preventative of hemorrhagic transformation as it occurred only in nonpregnant animals. MgSO4did not provide benefit to experimental preeclampsia animals for infarction.Conclusions:Stroke outcome was worse in a model of preeclampsia. As preeclampsia increases the risk of future stroke and cardiovascular disease, it is worth understanding the influence of preeclampsia on the material brain and factors that might potentiate injury both during the index pregnancy and years postpartum.

Ricerca finlandese, frequentare spazi verdi e blu

A Trieste presentazione libro, serata a favore Sistema pubblico

Introduction
It remains unknown whether psychological or psychosocial treatments for post-traumatic stress disorder (PTSD) have comparable effects across the life span. This study aims at comparing the effects of psychological/psychosocial treatments for PTSD between different age groups of youth, early-middle adults and late adults.

Methods and analysis
A systematic search will be conducted among thirteen electronic databases, including Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, EMBASE, ERIC, PubMed, SCOPUS, Web of Science, Published International Literature on Traumatic Stress, China National Knowledge Infrastructure Database, the Wanfang database, the Chinese Scientific Journal Database (VIP Database) and ProQuest Dissertations and Theses, from inception to 15 May 2022. Electronic searches will be supplemented by a comprehensive grey literature search in Conference proceedings and trial registries. Randomised controlled trials (RCTs) comparing psychological or psychosocial treatments for PTSD with control conditions in all age groups will be included. The primary outcome is the between-treatments efficacy for PTSD that refers to the outcomes of the RCTs included in the meta-analysis. Effect sizes will be calculated for all comparisons and pooled with a fixed effects model or a random effects model. Differences in the efficacy of psychological/psychosocial therapies for PTSD across the age groups will be examined by stratified analyses and meta-regression analyses.

Ethics and dissemination
Data used in this study will be anonymised. These data will not be used for other purposes than research. Authors who supply the data will be acknowledged. The authors declare that no conflicts of interest exist. The findings of this study will be disseminated through briefing reports, publications and presentations.

Trial registration number
CRD42022334305.

Studio sui comportamenti alimentari durante e dopo la pandemia

Campagna contribuirà a finanziamento di circa 5.000 ricercatori

Ricerca università pubblicata sulla rivista Pnas