Risultati per: Cardio-oncology: rivista open access

Stroke, Volume 53, Issue Suppl_1, Page ATMP72-ATMP72, February 1, 2022. Introduction:The transradial approach (TRA) is being increasingly adopted by neuro-interventionists and has emerged as an alternative to the traditional transfemoral approach (TFA) for mechanical thrombectomy (MT). We aim to compare various time, technical and outcome parameters in patients who undergo MT via TRF vs. TRA approach.Methods:We performed a retrospective chart review of patients who underwent MT at a comprehensive stroke center from 7/2014 to 12/2020. We compared patients who underwent MT via TRA vs. TRF with respect to time from angio suite arrival to puncture, first pass, second pass and recanalization; time from puncture to first pass, second pass and recanalization; time from arrival to the emergency department (ED) to puncture, first pass, second pass and recanalization; the number of passes, rate of switching, achievement of TICI≥2b score, functional independence (3-month mRS≤2), 3-month mortality and neurological improvement (improvement in NIHSS by ≥4 points) on day 1 and 3. A binary logistic regression analysis was performed, controlling for age, sex, NIHSS, type of anesthesia (general vs. moderate), laterality, and location of clot (internal carotid or middle cerebral artery), ASPECTS≥6, presenting mean arterial pressure, blood glucose, Hb A1C, LDL, intravenous alteplase.Results:217 patients met our inclusion criteria. The mean age was 64.09±14.4 years. 42 (19.35%) patients underwent MT through the TRA approach. There was a significantly higher rate of conversion from TRA approach to TRF approach (11.90% vs.2.28%; OR, 105.59; 95% CI,5.71-1954.67; P 0.002), but no difference in various time, technical and outcome parameters, as shown in the table.Conclusions:Our study demonstrates no significant difference between TRA and TRF approaches with respect to various time, technical and outcome parameters, with a notable exception of a significantly higher rate of conversion from TRA to TRF approach.

Stroke, Volume 53, Issue Suppl_1, Page AWP48-AWP48, February 1, 2022. Objective:Many U.S. emergency departments (EDs) lack access to stroke neurologists to support decision-making for thrombolytics and identification of thrombectomy-eligible patients. We outline a strategy to identify hospitals where telestroke might improve access and estimate potential gains in both the number of patients receiving reperfusion treatment and lives saved.Methods:We identified all EDs that provided ischemic stroke care for a Medicare beneficiary during 2018. We then excluded those with clear stroke expertise or with another ED with stroke expertise within 20 miles. At these EDs, we used annual ischemic stroke volumes and previously-derived risk ratios to quantify estimated marginal benefits (additional patients receiving reperfusion and additional lives saved) with the introduction of telestroke.Results:Among 4657 US EDs that provided stroke care in 2018, 1057 had limited stroke capabilities in their ED or within 20 miles. Of these 1057 EDs, 83.1% were in rural communities, and they cared for a median of 6 ischemic stroke patients per year. We estimate telestroke introduction to all 1057 would lead to 164 (95% CI 93-247) additional patients receiving reperfusion treatment and 90 (95% CI 2-180) additional lives saved annually (Figure). If only 263 EDs in the the top quartile of marginal benefit were targeted, this would capture over half of the estimated benefits.Conclusions:We estimate that approximately a quarter of U.S. EDs, primarily small rural EDs, would benefit most from new telestroke capacity. Our strategy may be used to improve stroke systems of care and maximize specialist access for the U.S. population.

Stroke, Volume 53, Issue Suppl_1, Page A74-A74, February 1, 2022. Introduction:In New York City (NYC), expanding the reach of thrombectomy-capable stroke centers (TSC) is key to combating socioeconomic disparities in stroke care. The Area Deprivation Index (ADI), a validated, neighborhood-level composite measure (scored 1-100) that includes income, education, employment, and housing quality, has informed healthcare delivery but has not been used to identify disadvantaged neighborhoods with poor access to stroke care. We sought to evaluate the impact of establishing Mount Sinai Queens Hospital (MSQ) as a TSC in 2017 on transfer times and to explore the association between ADI and stroke care access.Methods:Thrombectomy patient pick-up addresses were obtained through Emergency Medical Services runsheets from June 2016 to July 2021 and matched to census-tract level ADI scores from Neighborhood Atlas. Preliminary analyses compared both ADIs and time to stroke care access in both Queens and Manhattan. The primary outcome measure was the duration between ambulance arrival and groin puncture. Simple linear regression and T-tests were used to assess the association between ADI and time to groin puncture by borough.Results:Among 517 cases between 2016-2021, the average ADI of pick-up locations was 10.35 (range: 1 – 70.5). Across all centers, higher ADI (greater deprivation) was significantly associated with increased time to groin puncture (p = 0.024). Notably, Queens patients were picked up in census tracts with higher ADI (p=0.0289) but had a faster pick up to groin puncture time (p=0.006).Conclusions:Across urban census tracts, a higher ADI was associated with delays in access to thrombectomy. Thrombectomy centers in areas with higher ADI can play a role in reducing healthcare disparities for stroke patients.

Stroke, Volume 53, Issue Suppl_1, Page AWMP25-AWMP25, February 1, 2022. Introduction:Mechanical thrombectomy (EVT) is the standard of endovascular care for acute ischemic stroke secondary to large vessel occlusion. Alteplase in conjunction with EVT has a strong safety profile with low incidence of complications including groin hematoma. Our objective was to evaluate the incidence of groin hematoma in EVT following bridging therapy tenecteplase (TNK) as this is not well-described in the literature.Methods:Retrospective review of prospectively collected data for patients with acute ischemic stroke who underwent mechanical thrombectomy at a University Hospital. Incidence of access site complication including groin hematoma, retroperitoneal hematoma, blood loss and femoral artery pseudoaneurysm with or without the need for surgical intervention were reviewed. Rates of use of other antithrombotic agents were also noted. Social Science Statistics was used for data analysis.Results:From October of 2020 to April of 2021, of 348 ischemic stroke patients, 16 had LVO identified on CT and received TNK prior to mechanical thrombectomy (Females = 6; age, 63.25 95% CI [54.9207, 71.5793]); Mean weight =78kg, 95% CI [67.68, 88.32]). Five subjects (31.25%) received intra-arterial non-thrombolytics. None received intra-arterial thrombolytics. Three patients (18.75%) received therapeutic heparin during the procedure. Four patients (25%) were started on non-thrombolytic infusion during the periprocedural period. One subject (6.25%) was started on stroke nomogram heparin infusion less than 24 hours post-intervention. One subject (6.25%) developed groin hematoma that did not require intervention. This subject received intra-arterial non-thrombolytics during procedure and IV non-thrombolytics during the peri-procedural period.Conclusion:Our single center experience with TNK outside of the clinical trial setting with concomitant use of other antithrombotics suggests safety of bridging strategy. Larger prospective ‘real-life’ studies are required to validate our findings.

Stroke, Volume 53, Issue Suppl_1, Page A23-A23, February 1, 2022. Backgound:In 2011, nearly 20% of Americans lacked timely access to alteplase-capable hospitals. We update this work by assessing access to stroke centers and emergency departments (EDs) with telestroke capacity. Our objectives are to identify all US EDs with acute stroke capabilities (i.e., in a confirmed stroke center or with telestroke capacity), and to characterize the proportion of the US population with access to an ED with either capacity.Methods:We used the 2019 National ED Inventory-USA to identify all US EDs and characterize stroke capabilities by hospital stroke center status (none, acute stroke ready hospital [ASRH], primary stroke center [PSC], thrombectomy-capable or comprehensive stroke center [TSC/CSC]) and telestroke capacity. We used 2020 US Census data for census block group population and centroid. For each block group, we used ArcGIS to assess whether an ED with stroke expertise was within a 60 minute (min) response and transport time by ground emergency medical services (EMS). To determine the transport time, we used data from actual EMS stroke transports using the 2019 National EMS Information System with median EMS dispatch, response, and scene times in access calculations.Results:Of 5,587 US EDs, 2,563 (46%) were in a stroke center (691 ASRH, 1,505 PSC, 367 TSC/CSC); of these, 55% also had telestroke capacity. Of the 3,024 (54%) that were not a confirmed stroke center, 36% had telestroke. We estimate that 91% of the US population is within 60 min of a confirmed stroke center by ground EMS and 96% is within 60 min of a confirmed stroke center or telestroke ED (Figure). The percentage of the population without access to a confirmed stroke center or telestroke ED varied by region, from 1% in the Middle Atlantic to 9% in the West Mountain.Conclusion:Relative to previous reports, an increasing proportion of the US population has access to acute stroke expertise. While geographic disparities in access remain, telestroke plays an important role in filling this gap.

Stroke, Volume 53, Issue Suppl_1, Page A31-A31, February 1, 2022. Background:Critical access hospitals (CAHs) provide emergency and inpatient care in rural communities. CAHs have higher 30-day mortality after stroke, but little is known about long-term outcomes. We compared 1-year outcomes after ischemic stroke for patients treated at CAHs versus other hospitals.Methods:We identified all Medicare fee-for-service beneficiaries aged ≥65 years discharged alive from US hospitals with a principal diagnosis of ischemic stroke in 2015. Patients were followed 1 year for death or stroke recurrence, accounting for competing risks. We balanced characteristics between CAH and non-CAH patients using stabilized inverse probability weights (IPW) based on patient demographic and clinical characteristics. We created adjusted Kaplan-Meier curves based on the IPW and fit Cox models to assess differences in 1-year mortality and recurrent stroke weighted by the IPW.Results:There were 4,487 patients discharged with stroke from CAHs and 202,502 from non-CAHs. CAH vs non-CAH patients were older (mean age 82.8y vs 78.6y) and more often women (61.8% vs 53.9%), white (94.3% vs 83.7%), and dual Medicare-Medicaid eligible (21.6% vs 17.1%). Discharge to home (29.6% vs 36.8%) and inpatient rehabilitation (4.2% vs 18.9%) was less common for CAH patients, whereas discharge to an intermediate care/skilled nursing facility was more common (26.7% vs 23.9%). For CAHs and non-CAHs, respectively, 1-year mortality rates were 27.8% (95% CI 26.5-29.0) and 22.2% (22.0-22.4), and 1-year recurrence rates were 4.3% (3.6-4.9) and 4.6% (4.5-4.7) (Figure). In IPW-adjusted analyses, stroke patients treated at CAHs vs non-CAHs had higher risk of 1-year mortality (HR 1.29, 95% CI 1.22-1.37) but not recurrent stroke (0.91, 0.78-1.06).Conclusions:Stroke patients discharged from CAHs vs non-CAHs had greater risk of 1-year mortality but not recurrence. Further work is needed to understand the observed disparity, potentially with a focus on post-acute care services.

Stroke, Volume 53, Issue Suppl_1, Page ATP27-ATP27, February 1, 2022. Background:C3FIT (Coordinated,Collaborative,Comprehensive,Family-based,Integrated,Technology-enabled Stroke Care) is a pragmatic, multi-centered. cluster-randomized trial to assess the superiority of patient outcomes when Joint Commission-certified Stroke Centers or Primary Stroke Center (CSC/PSC) are supplemented with an Integrated Stroke Practice Unit (ISPU) model of care at 9 of 18 hospitals across the United States. We describe participant satisfaction with technology solutions used to improve access during a Pandemic.Methods:Participating sites were randomized to the CSC/PSC or ISPU Model, enrolling 100/site (n=1800). Guided by Kotter’s process for leading change, ISPU patient-centric (patient/ caregiver) model provides care through two coordinated units addressing acute assessment/diagnosis/intervention (Stroke Central or SM) through hospital discharge to 1-year post-stroke (Stroke Mobile or SMT). SMT includes a Registered Nurse and Lay Health Educator working with participants for 12 monthly visits at home/facility post-stroke. A participant satisfaction tool was used to assess their ability and preference to use technology.Results:Enrollment began February 2020. March 2020 the Pandemic affected the study by: 1. Facilities altering visitation policies inhibiting SC/SMT interaction with participants to consent, 2. Facilities limited participant follow-up in their homes by SMT, 3. Participants limited in-home visits by SMT, 4. Institutional research programs were held. The Clinical Coordinating Center met challenges by adding phone visits, smart phone application and I-PADS for participant follow-up. ISPU sites increased phone/virtual visits to 89 %; home visits decreased to 9.9%. Participant’s survey found 94.7% were very or extremely satisfied with their “ability to use the virtual technology;” 28.4% preferred virtual follow-up; 40.9% preferred in-person; 30.7% preferred phone visits.Conclusion:Conducting this study during the Pandemic presented challenges to enrollment and follow-up. Participants reported satisfaction with technology as a possible solution to improve clinical access. >

Stroke, Ahead of Print.