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To the Editor A recent study shed light on the potential value of FIT combined with HPSA testing in gastric cancer screening, while also indirectly highlighting the potential link between H pylori infection and colorectal carcinogenesis. We would like to discuss aspects of the study that require careful interpretation and further exploration.
To the Editor Dr Lee and colleagues conducted a randomized, population-based trial in Taiwan to assess whether the addition of the Helicobacter pylori stool antigen (HPSA) test to the standard fecal immunochemical test (FIT) could reduce gastric cancer incidence and mortality. The study reported no significant differences between the 2 groups in gastric cancer incidence (0.032% vs 0.037%; P = .23) or mortality (0.015% vs 0.013%; P = .57). Several points merit further discussion.
Iniziativa all’Università Politecnica delle Marche
Iniziativa all’Università Politecnica delle Marche
Smoking causes 1 in 3 cancer deaths and nearly 9 in 10 lung cancer deaths. People who smoke cigarettes are 15 to 30 times more likely to be diagnosed with lung cancer and die of lung cancer than people who do not smoke. The heavier the smoking and the more years of exposure, the greater the risk. Although lung cancer has an overall 5-year survival rate of 26.7%, early detection improves survival. The National Lung Screening trial and the NELSON trial, both landmark randomized clinical trials of lung cancer screening (LCS) with low-dose computed tomography, have shown an approximate 20% reduction in risk of lung cancer mortality with annual screening.
This randomized clinical trial evaluates the effectiveness of smoking cessation interventions of varying intensities in the lung cancer screening setting.
Rapporto Farmacia, ‘presidio contro desertificazione sanitaria’
Rapporto Farmacia, ‘presidio contro desertificazione sanitaria’
New England Journal of Medicine, Volume 392, Issue 9, Page 929-930, February 27, 2025.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
Annals of Internal Medicine, Ahead of Print.
To the Editor The US Preventive Services Task Force (USPSTF) recently released a recommendation restating that “the current evidence is insufficient to assess the balance of benefits and harms of screening for iron deficiency and iron deficiency anemia in pregnant persons to prevent adverse maternal and infant health outcomes.” We are concerned that if clinical judgment regarding whether to screen for iron deficiency and iron deficiency anemia and whether to provide routine iron supplementation during pregnancy is not done in a liberal fashion, serious consequences may arise for female patients who have complex blood group antigen constellations. Similarly, screening for iron deficiency during pregnancy may be important for individuals who do not want to receive donor blood.
In Reply The USPSTF prioritized reviewing the evidence on screening and supplementation for iron deficiency and iron deficiency anemia during pregnancy because of the association between iron deficiency and adverse maternal and newborn health outcomes, although certain factors (eg, baseline nutritional status) may affect this relationship.
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