Food insecurity and other barriers to adherence to a gluten-free diet in individuals with coeliac disease and non-coeliac gluten sensitivity in the Netherlands: a mixed-methods study

Objectives
To determine the prevalence of food insecurity among individuals with coeliac disease (CeD) and non-coeliac gluten sensitivity (NCGS) in the Netherlands and explore its association with diet quality and other barriers to adherence to a gluten-free diet.

Design
Mixed-method design comprising a survey and semistructured interviews.

Setting
An online survey was distributed through social media accounts and the newsletter of the Dutch Association for Celiac Disease. Community-dwelling patients were surveyed and interviewed between June and November 2023.

Participants and outcome measures
In total 548 adults with CeD and NCGS in the Netherlands who adhered to a gluten-free diet completed the survey including questions related to demographics, household food insecurity, financial stress and diet quality. Regression analyses were conducted to assess associations between food insecurity and diet quality, and between food insecurity and perceived difficulty of gluten-free eating and cooking. Additionally, semistructured interviews with eight food insecure adults with CeD were conducted.

Results
The prevalence of food insecurity was 23.2%, with 10.4% reporting very low food security. Very low food insecurity was associated with poorer diet quality (β=–5.5; 95% CI=–9.2 to –1.9; p=0.003). Food insecurity was associated with heightened perceived barriers across multiple themes. In age, income and education adjusted models, compared with food secure participants, low food secure participants were more likely to experience difficulty regarding skills (OR=2.5; 95% CI=1.5 to 4.3; p≤0.001), social circumstances (OR=2.6; 95% CI=1.1 to 6.4; p=0.038), resources (OR=2.5; 95% CI=1.5 to 4.4; p=0.001) and naturally gluten-free products (OR=1.8; 95% CI=1.0 to 3.1; p=0.045) in gluten-free eating and cooking. Participants with very low food security were more likely to experience difficulty regarding skills (OR=4.4; 95% CI=2.4 to 8.1; p≤0.001) and resources (OR=4.2; 95% CI=2.3 to 7.8; p

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Association between sleep quality and uncertainty stress among healthcare professionals in hospitals in China: a nationwide cross-sectional survey

Objectives
Sleep quality is a critical concern among healthcare professionals, yet the role of uncertainty stress has been inadequately explored. This study aims to explore the associations between sleep quality and uncertainty stress among healthcare professionals working in Chinese hospitals.

Design
Cross-sectional survey.

Setting
Data were collected via a cross-sectional survey administered to healthcare professionals across three Chinese provinces from 29 September 2022 to 18 January 2023.

Participants
A total of 1902 participants contributed valid responses for analysis.

Primary outcome measure
Sleep quality.

Results
Out of 1902 respondents, 26.4% reported uncertainty stress and 50.5% experienced insomnia. Binary logistic regression analysis revealed that higher uncertainty stress significantly predicted poor sleep quality (OR=3.89; 95% CI 3.06, 4.95; p

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Virtual reality-guided mindfulness intervention to enhance psychosocial well-being in caregivers of end-stage kidney disease patients: protocol for a mixed-methods pilot randomised controlled trial

Introduction
Caregivers of patients with end-stage kidney disease (ESKD) face significant challenges that contribute to caregiver burden, negatively impacting their psychosocial well-being. Virtual-reality (VR)-guided mindfulness interventions have shown promise in reducing stress, anxiety and depression in various populations.

Methods and analysis
This pilot study aims to evaluate the efficacy and feasibility of a VR-guided mindfulness intervention for ESKD caregivers. A single-centre, single-blind, parallel-group pilot randomised controlled trial will be conducted. Thirty ESKD caregivers will be randomly allocated to either the VR-guided mindfulness intervention group or the sham VR control group. The intervention group will receive a 6 week home-based VR-guided mindfulness programme, while the control group will view relaxing nature videos without mindfulness content. Participants will be assessed at baseline, post-intervention (6 weeks) and follow-up (12 weeks) using validated questionnaires for caregiver burden (Zarit Burden Interview (ZBI)), stress, anxiety, depression (Depression Anxiety Stress Scale-21 (DASS-21)), quality of life (36-Item Short Form Health Survey (SF-36)) and mindfulness (Five Facet Mindfulness Questionnaire (FFMQ)). Feasibility outcomes include accrual rates, retention, adherence, questionnaire completion and side effect rates. Semi-structured interviews will explore participants’ experiences with the intervention.

Ethics and dissemination
The study has been approved by the NHG Domain Specific Review Board (Reference: 2024–3940-APP1). The results of this pilot study will be reported in peer-reviewed open-access journals and shared with participants and stakeholders.

Trial registration
NCT06479200.

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Cyberbullying victimisation and its association with depression, anxiety and stress among female adolescents in Deumai Municipality, Nepal: a cross-sectional survey

Objective
To estimate the prevalence of cyberbullying and its association with depression, anxiety and stress among female adolescents attending higher secondary schools in Deumai Municipality, Nepal.

Design
Cross-sectional survey study.

Setting
The survey was conducted at all available higher secondary schools of Deumai Municipality, Ilam District, Nepal, from February to April 2022.

Participants
A total of 501 female adolescents enrolled in grades 11 and 12 were included in the study. All eligible participants available on the day of data collection were approached until the calculated sample size was reached.

Outcome measures
The study assessed the prevalence of cyberbullying victimisation, along with the prevalence of depression, anxiety and stress and their associated factors. The level of psychological distress was explored using the Depression Anxiety Stress Scale-21. Pearson’s 2 test and multivariate logistic regression analysis were applied to determine the association between psychological distress and related variables, including cyberbullying victimisation, at 95% CI and 5% level of significance.

Results
Nearly a third (32.5%) of the female adolescents included in the study had experienced cyberbullying. The overall prevalence of depression, anxiety and stress was 46.5%, 52.7% and 34.9%, respectively. Cyberbullying victims were observed to have increased odds of experiencing depression (adjusted OR (aOR): 1.64, 95% CI 1.11 to 2.42), anxiety (aOR: 2.49, 95% CI 1.67 to 3.70) and stress (aOR: 2.59, 95% CI 1.74 to 3.86) in comparison with non-victims.

Conclusion
Cyberbullying victims are significantly more likely to experience psychological distress. There is an urgent need to strengthen cybersecurity and to have strong legislative measures to address cyberbullying in order to safeguard the mental health of adolescents in the digital age.

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Profiles and associated factors of prenatal psychological symptoms and their association with health-related quality of life among pregnant women: a cross-sectional study

Objectives
To cluster prenatal psychological symptoms into different profiles and investigate prenatal psychological symptoms’ sociodemographic, health-related and pregnancy-related factors. Furthermore, health-related quality of life was compared across prenatal psychological symptom profiles.

Design
Cross-sectional study.

Setting
Obstetrics clinics of two university-affiliated, governmental, tertiary hospitals in Xi’an City, Northwestern China.

Participants
Between June and August 2020, 1020 pregnant women who maintained their health assessment appointments at the two research sites participated in this study.

Primary and secondary outcome measures
This study’s primary outcome was the creation of latent profiles of prenatal psychological symptoms. These were represented by the coexisting symptoms of three common psychological disorders: depression measured using the eight-item Patient Health Questionnaire, anxiety measured using the Generalised Anxiety Disorder-7 and stress measured using the Pregnancy Stress Rating Scale. Secondary outcomes included potential sociodemographic, health-related and pregnancy-related factors associated with prenatal psychological symptoms, which were measured using a researcher-designed information sheet, and health-related quality of life, measured using the 5-Level EuroQol 5-Dimension questionnaire.

Results
Prenatal psychological symptoms were classified into three latent profiles using latent profile analysis: low (62.9%), moderate (31.3%) and severe (5.8%). Factors associated with the severity of prenatal psychological symptoms included age, relationship with partner, relationship with mother-in-law, history of gynaecological diseases, history of dysmenorrhoea, stage of pregnancy, unplanned pregnancy, severity of vomiting symptoms and abnormal pregnancy indicators. Moreover, an inverse association was identified between the severity of prenatal psychological symptoms and health-related quality of life.

Conclusions
Considering the high prevalence of prenatal psychological symptoms and their adverse effects on health-related quality of life, the assessment of prenatal psychological symptoms should be integrated into prenatal healthcare and made routine practice. Investigating the relevant associated factors would be beneficial for identifying vulnerable individuals.

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