Risultati per: Le campagne di screening come strumento di prevenzione oncologica tra dubbi e certezze

Men who were screened more frequently received more prostate cancer diagnoses but not earlier treatment.

New England Journal of Medicine, Volume 388, Issue 15, Page 1405-1414, April 2023.

Analizza informazioni su dati genomici concentrandosi su 31 geni

Many screening colonoscopies are done in patients with limited life expectancy.

Annals of Internal Medicine, Ahead of Print.

In Toscana e Veneto progetto pilota con 400mila test

In this issue of JAMA Internal Medicine, Lee and colleagues reported the results of a stepped-wedge cluster randomized implementation trial aimed at identifying and decreasing unhealthy alcohol use among primary care patients. The intervention by Lee et al significantly increased screening and brief counseling about unhealthy alcohol use in primary care patients but did not increase treatment of alcohol use disorder (AUD).

The US Preventive Services Task Force has reaffirmed its 2016 recommendation against population-based serologic genital herpes screening in asymptomatic adults and adolescents, including pregnant persons (D recommendation). With little new data identified in a focused evidence update (ie, no new eligible studies were included), the current 2023 recommendation reaffirmed with moderate certainty that the potential harms of serologic screening for genital herpes simplex virus (HSV)-2 infection in asymptomatic individuals outweigh potential benefits. This recommendation aligns with corresponding guidelines from the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists.

Ridotta del 30% incidenza e gravità grazie a prevenzione

Ridotta del 30% incidenza e gravità grazie a prevenzione

Researchers describe the performance of a brief instrument that requires no reading, writing, or drawing.

Objectives
The 2020–2022 research project ‘Colorectal Cancer Screening Intervention for Malaysia’ (CRC-SIM) evaluated the implementation of a home-based CRC screening pilot in Segamat District. This budget impact analysis (BIA) assessed the expected changes in health expenditure of the Malaysian Ministry of Health budget in the scenario where the pilot programme was implemented nationwide vs current opportunistic screening.

Design
Budget impact analysis. Assumptions and costs in the opportunistic and novel CRC screening scenarios were derived from a previous evaluation of opportunistic CRC screening in community health clinics across Malaysia and the CRC-SIM research project, respectively.

Setting
National level (with supplement analysis for district level). The BIA was conducted from the viewpoint of the federal government and estimated the annual financial impact over a period of 5 years.

Results
The total annual cost of the current practice of opportunistic screening was RM1 584 321 (~I$1 099 460) of which 80% (RM1 274 690 or ~I$884 587) was expended on the provision of opportunistic CRC to adults who availed of the service. Regarding the implementation of national CRC screening programme, the net budget impact in the first year was estimated to be RM107 631 959 (~I$74 692 546) and to reach RM148 485 812 (~I$103 043 589) in the fifth year based on an assumed increased uptake of 5% annually. The costs were calculated to be sensitive to the probability of adults who were contactable, eligible and agreeable to participating in the programme.

Conclusions
Results from the BIA provided direct and explicit estimates of the budget changes to when implementing a population-based national CRC screening programme to aid decision making by health services planners and commissioners in Malaysia about whether such programme is affordable within given their budget constraint. The study also illustrates the use and value of the BIA approach in low-income and middle-income countries and resource-constrained settings.

In 20 piazze, tra novità spazio dedicato agli animali da compagnia

Circulation, Ahead of Print. BACKGROUND:Managing disease risk among first-degree relatives of probands diagnosed with a heritable disease is central to precision medicine. A critical component is often clinical screening, which is particularly important for conditions like dilated cardiomyopathy (DCM) that remain asymptomatic until severe disease develops. Nonetheless, probands are frequently ill-equipped to disseminate genetic risk information that motivates at-risk relatives to complete recommended clinical screening. An easily implemented remedy for this key issue has been elusive.METHODS:The DCM Precision Medicine Study developedFamily Heart Talk, a booklet designed to help probands with DCM communicate genetic risk and the need for cardiovascular screening to their relatives. The effectiveness of theFamily Heart Talkbooklet in increasing cardiovascular clinical screening uptake among first-degree relatives was assessed in a multicenter, open-label, cluster-randomized, controlled trial. The primary outcome measured in eligible first-degree relatives was completion of screening initiated within 12 months after proband enrollment. Because probands randomized to the intervention received the booklet at the enrollment visit, eligible first-degree relatives were limited to those who were alive and not enrolled on the same day as the proband.RESULTS:Between June 2016 and March 2020, 1241 probands were randomized (1:1) to receiveFamily Heart Talk(n=621) or not (n=620) within strata defined by site and self-identified race/ethnicity (non-Hispanic Black, non-Hispanic White, or Hispanic). Final analyses included 550 families (n=2230 eligible first-degree relatives) in theFamily Heart Talkarm and 561 (n=2416) in the control arm. A higher percentage of eligible first-degree relatives completed screening in theFamily Heart Talkarm (19.5% versus 16.0%), and the odds of screening completion among these first-degree relatives were higher in theFamily Heart Talkarm after adjustment for proband randomization stratum, sex, and age quartile (odds ratio, 1.30 [1-sided 95% CI, 1.08–∞]). A prespecified subgroup analysis did not find evidence of heterogeneity in the adjusted intervention odds ratio across race/ethnicity strata (P=0.90).CONCLUSIONS:Family Heart Talk,a booklet that can be provided to patients with DCM by clinicians with minimal additional time investment, was effective in increasing cardiovascular clinical screening among first-degree relatives of patients with DCM.REGISTRATION:URL:https://clinicaltrials.gov; Unique identifier: NCT03037632.

Colorectal cancer (CRC) screening guidelines include screening-colonoscopy and sequential high sensitivity fecal occult blood testing (HSgFOBT), with expectation of similar effectiveness based on the assumption of similar high adherence. However, adherence to screening-colonoscopy compared to sequential HSgFOBT has not been reported. In this randomized clinical trial, we assessed adherence and pathology findings for a single screening-colonoscopy versus sequential and non-sequential HSgFOBT.