Risultati per: BRCA e Adenoma del pancreas metastatico

In Reply We thank Dr Narod for his comment on our recent research article evaluating the safety of pregnancy following breast cancer in young women with germline BRCA pathogenic or likely pathogenic variants. In his Letter, Narod noted that our primary analysis did not control for the potentially protective effect of risk-reducing bilateral salpingo-oophorectomy in this patient cohort.

To the Editor In the article by Dr Lambertini and colleagues on pregnancy after breast cancer in young BRCA carriers, the authors compared the outcomes of patients with breast cancer and BRCA1 or BRCA2 variants according to whether or not they had a pregnancy after having breast cancer. They found no effect of pregnancy on the outcome of disease-free survival (local recurrence, contralateral breast cancer, distant recurrence) (hazard ratio, 0.99; 95% CI, 0.81-1.20) but found a significant improvement in breast cancer–specific survival (death due to breast cancer) with pregnancy (hazard ratio, 0.53; 95% CI, 0.37-0.74; P 

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