Risultati per: La composizione del microbioma influenza la depressione

In Italia l’Aifa ha autorizzato un vaccino contro l’influenza in spray nasale per i bambini e ragazzi fino ai 18 anni

Aifa, ceppi virali aggiornati secondo raccomandazioni dell’Oms

Così dicono i segnali che arrivano dall’emisfero Sud del mondo dove con il passaggio dell’inverno i virus si sono massicciamente affacciati

New England Journal of Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Vaia, “impegno per la campagna”. In Usa preoccupa l’aviaria

New England Journal of Medicine, Ahead of Print.

Studio, “è una misura contro i sintomi correlati all’invecchiamento”

Il sole incide sull’efficacia.Servono trattamenti personalizzati

Esperti, organizzazione e comunicazione per aumentare coperture

Annals of Internal Medicine, Volume 177, Issue 7, Page 990, July 2024.

Annals of Internal Medicine, Volume 177, Issue 7, Page 990-991, July 2024.

Annals of Internal Medicine, Volume 177, Issue 7, Page 991, July 2024.

Another study supports an association between influenza and subsequent MI.

Introduction
Children and adolescents with recent-onset type 1 diabetes (T1D) commonly maintain a certain level of insulin production during the remission phase, which can last months to years. Preserving β-cell function can reduce T1D complications and improve glycaemic control. Influenza vaccination has pleiotropic effects and administration of the vaccine during the early phases of T1D may offer β-cell protection. This study aims to assess the effect of influenza vaccination on preserving β-cell function in children and adolescents with recent-onset T1D.

Methods and analysis
The INfluenza VaccInation To mitigate typE 1 Diabetes trial is a randomised, double-blind, placebo-controlled, multicentre trial in paediatric patients with recent-onset T1D aged 7–17 years. 100 participants will be randomised in a 1:1 ratio to receive either a standard inactivated quadrivalent influenza vaccine or a placebo within 14 days of diagnosis. The primary outcome is a difference in mean change (from baseline to 12 months) in C-peptide level between groups during a 2-hour mixed-meal tolerance test. Secondary outcomes include mean change (from baseline to 6 months) in C-peptide levels, haemoglobin A1c, ambulatory glucose profiles and insulin requirements. Exploratory outcomes are diabetes-related autoantibodies, inflammatory markers and serum haemagglutinin inhibition antibody titres against the influenza viruses. The current treatment for T1D is largely symptomatic, relying on insulin administration. There is a pressing need for novel pharmacological approaches aimed at modulating the immune system to preserve residual β-cell function. Existing immunotherapies are cost-prohibitive and associated with multiple side effects, whereas influenza vaccination is inexpensive and generally well tolerated. A positive outcome of this study holds potential for immediate implementation into standard care for children and adolescents with recent-onset T1D and may guide future research on immune modulation in T1D.

Ethics and dissemination
Ethical approval was obtained from Danish Health Authorities prior to participant enrollment. The trial results will be submitted to a peer-reviewed journal.

Trial registration number
ClinicalTrials.gov NCT05585983 and EudraCT Number 2022-500906-17-01.