Disponibili i risultati del primo trial clinico dopo 52 settimane
Search Results for: La scansione cerebrale può diagnosticare il morbo di Alzheimer
Here's what we've found for you
Alzheimer, la stimolazione magnetica dimezza la progressione della malattia
Disponibili i risultati del primo trial clinico dopo 52 settimane
Alzheimer, stimolazione magnetica dimezza progressione malattia
Disponibili risultati primo trial clinico dopo 52 settimane
Alzheimer, più rischi con poche ore di sonno profondo
La fase Rem carente riduce il volume di un’area del cervello
Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes
Circulation, Ahead of Print. BACKGROUND:Shared genetic and lifestyle risk factors may underlie the development of both coronary artery disease (CAD) and dementia. We examined whether an increased genetic risk for CAD is associated with long-term risk of developing all-cause, Alzheimer’s, or vascular dementia, and investigated whether differences in potentially modifiable lifestyle factors in the mid- to late-life period may attenuate this risk.METHODS:A prospective cohort study of 365 782 participants free from dementia for at least 5 years after baseline assessment was conducted within the UK Biobank cohort. Genetic risk was assessed using a genomewide polygenic risk score (PRS) for CAD and lifestyle risk using a modified version of the American Heart Association’s Life’s Essential 8 Lifestyle Risk Score (LRS). Higher values for both scores were deemed to represent increased risk. Primary outcomes were incident all-cause, Alzheimer’s, and vascular dementia diagnoses obtained from electronic health records. Secondary outcomes were neuroimaging phenotypes measured in 32 028 participants recalled for magnetic resonance imaging. Sensitivity analyses were conducted to test the extent by which biological and behavioral risk factors contributed to observed associations.RESULTS:A total of 8870 cases of all-cause dementia were observed over a median 13.9-year follow-up. Both genetic (PRS) and lifestyle (LRS) risk scores for CAD were associated with a modestly elevated risk of all-cause dementia (subhazard ratio per SD increase, 1.10 [1.08, 1.12],P
Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
This cohort study evaluates the association between extreme heat and the risk of hospitalization with Alzheimer disease and related dementias in the US.
Disturbo bipolare, altalena dell'umore per 80 milioni nel mondo
Il 30 marzo la Giornata mondiale,ancora stigma ma curarlo si può
Melanoma e tumore del polmone, Aifa approva l'immunoterapia in fase precoce
Ok alla rimborsabilità negli stadi iniziali della malattia, può aumentare le guarigioni
Development and evaluation of a healthcare decision-making intervention for African American parent-adult daughter dementia dyads: a mixed-methods study protocol
Introduction
There is a higher proportion of African American care partners due to African American older adults having more than twice the prevalence of Alzheimer’s disease and related dementias (ADRD) compared with non-Hispanic white older adults in the USA. African American adult daughters are the largest group of care partners of African American persons living with ADRD. Within this role, they are faced with navigating multiple health-related decisions to optimise the quality of life of their parent with ADRD, which can negatively influence their own quality of life. This study is guided by three conceptual frameworks: National Institute on Aging’s Health Disparities Research Framework, Black Family Socio-Ecological Context Model and Superwoman Schema. The purpose of this study was to develop a structured culturally responsive prototype intervention that will improve the healthcare decision-making self-efficacy and quality of life of African American parent-adult daughter dementia dyads. The prototype intervention will be piloted in a single-group clinical trial to evaluate feasibility, acceptability and preliminary efficacy.
Methods and analysis
This study will be conducted in two phases using an explanatory sequential mixed-methods design, wherein qualitative data collection follows quantitative data collection to explain the findings. In the first phase, the quantitative data collection will examine the behavioural, sociocultural and environmental lifecourse influences on healthcare decision-making self-efficacy and the quality of life of 70 African American parent-adult daughter dementia dyads (ie, persons living with ADRD and their adult daughter care partners). The qualitative data collection will consist of a nested sample of 15 dementia dyads and focus on the decision-making processes that affect current and future healthcare use for the parents living with ADRD. Further, this study will explore how these processes influence the quality of life of both members. In phase 2, integrated findings from phase 1 will provide the basis for the development of the prototype intervention using design thinking and intervention mapping with key informants and community advisory board oversight. Once the prototype intervention is developed, a clinical trial will be conducted. This trial will enrol a new sample of 20 African American parent-adult daughter dementia dyads using a pretest–post-test design.
Ethics and dissemination
The first phase of the study has been approved by the Emory University Institutional Review Board and is registered on ClinicalTrials.gov (NCT05139290). This study will contribute to the development of a structured culturally responsive prototype intervention for African American parent-adult daughter dementia dyads. The findings will determine whether a larger randomised controlled trial is warranted. Results of the research will be disseminated in both academic and community settings.
Trial registration number
NCT05139290.
Dopo il broncospasmo si può rischiare nuova polmonite
La pneumologa Dagmar Rinnenburger: “L’aspirazione per evitare infezione da ingestione”
Linee guida sulla degenerazione maculare legata all’età
La forma neovascolare della degenerazione maculare legata all’età (AMD) è […]
IA, giovane ricercatore nato con paralisi cerebrale diventa cavaliere dell'ordine al merito
L’onorificenza sarà conferita da Mattarella a Giovanni Arras. ‘La mia esperienza diretta con la disabilità mi ha dato una prospettiva unica sulla ricerca’
Blood Biomarkers to Detect Alzheimer Disease
To the Editor In their excellent research, Dr Palmqvist and colleagues report high diagnostic accuracy of blood biomarkers in the diagnosis of Alzheimer disease. The authors used the STROBE checklist for observational studies, but this is a prospective diagnostic accuracy study, for which the STARD checklist is more appropriate.
Blood Biomarkers to Detect Alzheimer Disease—Reply
In Reply We appreciate the opportunity to respond to Dr Mintzker’s thoughtful comments regarding our study on the diagnostic accuracy of blood biomarkers for the detection of Alzheimer disease.
Schillaci, finanziato con 35 milioni Fondo per l'Alzheimer
‘Ministero continuerà a sostenere la ricerca in questo settore’
Resilience-promoting social networks among unpaid dementia caregivers: protocol for a mixed-methods, 2-year exploratory study
Introduction
Unpaid caregivers of people living with dementia often experience lower levels of perceived life satisfaction and higher rates of depression and anxiety compared with those caring for individuals without Alzheimer’s disease or related dementias. While research on unpaid caregiver well-being and satisfaction has primarily focused on the characteristics of people living with dementia and their dyadic relationships, it has not adequately explored the role of social networks in supporting unpaid caregiver well-being. In this study, we aim to fill this gap by taking an egocentric social network approach to understand the multiple dimensions of social relations among unpaid caregivers of people living with Alzheimer’s disease or related dementia.
Methods and analysis
We will conduct a mixed-method, 2-year exploratory study that involves a structured survey-based telephone interview in year 1 and semistructured interviews in year 2 with caregivers of PLWD recruited through community and healthcare partners. Participants will participate in 1 60-min interview in year 1 (n=100) and a 45–60 min semistructured interview in year 2 (n=75). Eligibility for caregivers includes being an unpaid caregiver, aged 40 years or older, residing and providing care in Arizona or Nevada. The survey consists of questions about caregiver and care recipient demographics, caregiver background, caregiver stress, resilience, well-being and egocentric social network data. Network composition attributes, such as tie strength, the function of the relationship and reliance on network members, will also be assessed. In year 2, qualitative semistructured interviews will supplement these quantitative measures to understand network selection, perceived network changes over time and network strength.
Ethics and dissemination
The Arizona State Institutional Review Board (00018191) approved this study. All participants will receive electronic informed consent documents to review and sign. During the initial interview, participants will be asked if they have any questions about the informed consent documents. We will confirm that participants have completed the required consent form before the start of any research activity. The findings of this study will be disseminated through peer-reviewed journal articles, academic and community presentations, and community-focused publications targeting caregivers.