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Atrioventricular Block: Does This Patient Require a Pacemaker?
Circulation, Volume 148, Issue 21, Page 1725-1727, November 21, 2023.
Sport e Salute e Regione Liguria sottoscrivono protocollo Cuore
L’ad Nepi: ‘impegno per portare lo sport a tutti’
Le malattie del cuore come il diabete, gli screening sono salvavita per gli anziani
I dati dello studio Prevasc: “evitabili 150 mila decessi l’anno”
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Abstract 13098: Worsening Tricuspid Regurgitation Associated With Permanent Pacemaker and Implantable Cardioverter-Defibrillator Implantation: A Systematic Review and Meta-Analysis of Over 66,000 Patients
Circulation, Volume 148, Issue Suppl_1, Page A13098-A13098, November 6, 2023. Introduction:Worsening TR following either PPM or ICD implantation is an emerging clinical challenge. Early recognition of this entity is essential in guiding treatment.Hypothesis:Despite many technological advances in electrophysiology, transvenous lead placement currently remains an integral part of cardiac device implantation procedures. While worsening of TR post-device does not seem to be surprising, it is counter-intuitive and eventually leads to right-sided heart failure symptoms.Methods:We searched electronic databases from inception to January 2023 for published studies that reported incidence of TR worsening post-device implantation. Log odds ratio was used to summarize group differences.Results:Our analysis included 29 studies with 66,590 participants. Patients with device implantation (n=1,008) were significantly more likely to develop worsening TR as compared to controls (n=58,605) (OR: 3.18, p
Abstract 14310: Evaluation of Ventricular Pacing Suppression Algorithmsin Dual Chamber Pacemaker: Results of 'Leader' Study
Circulation, Volume 148, Issue Suppl_1, Page A14310-A14310, November 6, 2023. Introduction:Several algorithms have been proposed to reduce unnecessary right ventricular (RV) pacing, and their operations are based on two different mechanisms: (i) atrioventricular (AV) hysteresis (AVH) and (ii) DDD to AAI pacing mode change.Hypothesis:The purpose of our study was to evaluate the efficacy and safety of two ventricular pacing suppression algorithms: Intrinsic Rhythm Support (IRS) plus algorithm (using AVH, IRSplus) and VP suppression (DDD to AAI mode change) algorithm (VpS).Methods:This was a multicenter, randomized study conducted in 11 tertiary hospitals in South Korea. Patients with sinus node dysfunction and receiving dual-chamber permanent pacemaker implantation were included in this study. After the implantation, patients maintained a fixed AV interval for three months. The AV conduction time was determined as the “atrial pacing to ventricular sensing interval” observed from the marker channel during the PPM implantation was set as the sensed AV delay. The paced AV delay was set to be the sensed AV delay+30ms. Subsequently, patients were randomly assigned to either the VpS or IRSplus algorithm group and were followed for 12 months with assessments every 6 months.Results:A total of 118 patients were enrolled, and the total RV pacing percentage (Vp%) of the patients during the 3 months with a fixed AV interval was 10.9±16.0 on average. They were randomly assigned to VpS and IRSplus groups, with 62 and 56 patients in each group. Six months later, the average Vp% was 14.6±18.8 to 2.7±6.0, P
Abstract 11516: Micra vs Transvenous Pacemaker: A Comparative Systematic Review and Meta-Analysis
Circulation, Volume 148, Issue Suppl_1, Page A11516-A11516, November 6, 2023. Background:Leadless pacemakers (LP) represent an emerging modality for treating bradyarrhythmias. We performed a meta-analysis and systematic review comparing safety and efficacy outcomes of Micra LP and transvenous pacemakers (TVP).Methods:A literature search was performed. The primary efficacy endpoints were successful implantation rate and acceptable capture threshold of
Abstract 16204: Scaling Hearts: Exploring the Link Between Psoriasis and Infective Endocarditis in Pacemaker Patients
Circulation, Volume 148, Issue Suppl_1, Page A16204-A16204, November 6, 2023. Introduction:Device related infective endocarditis (IE) is associated with high morbidity and mortality resulting in a growing emphasis on identifying and managing comorbidities that increase the risk of IE in these patients. Psoriasis, a chronic inflammatory skin disorder with multifactorial etiology, is increasingly being identified as having multiple cardiovascular manifestations. However, little is known about the impact of psoriasis on IE risk in patients with permanent pacemaker (PPM).Hypothesis:Psoriasis patients with PPM have an increased risk of developing IE.Methods:Patients with a history of PPM implantation were sampled from the National Inpatient Sample Database (2016 – 2018). Comorbidities were identified using ICD-10 codes. Individuals with age < 18, history of endocarditis, immunosuppression, central line associated infections, intravenous drug use, and implantable cardiac defibrillators were excluded. Patients were stratified into two groups based on the presence of psoriasis. A univariate analysis followed by a multivariate analysis adjusting for age, gender valvular disease, dental infections, coronary artery disease, and sixteen other comorbidities was performed. Furthermore, 1:10000 propensity score matching was performed between the psoriasis and non-psoriasis groups and rates of IE were calculated.Results:Out of the 437,728 patients included in the study, 45 (4.4%) had psoriasis. Psoriasis patients were older and had more coronary artery disease. Psoriasis patients had significantly higher rates of endocarditis (4.4% vs 0.6%; p
Abstract 12729: Leadless Pacemaker Insertion is Safe in Nonagenarians
Circulation, Volume 148, Issue Suppl_1, Page A12729-A12729, November 6, 2023. Introduction:Increased age is associated with increased frailty and often worse postoperative outcomes. We aim to assess the safety of leadless pacemaker (LPM) insertion in the very elderly population.Methods:We queried the National Readmission Database years 2017-2020 for patients who underwent LPM insertion with the ICD10 code 02HK3NZ. Patients with age 90 or more were included in the nonagenarians group. Patient comorbidities were queried through the appropriate ICD 10 codes. We compared outcomes using multivariate logistic and linear regression, adjusting for patient comorbidities.Results:At baseline, nonagenarians had a higher prevalence of hypertension, history of stroke, A fib./A. flutter, dementia and hypothyroidism. The control group had more of diabetes, coronary disease, chronic kidney disease, chronic pulmonary disease, oxygen use, coagulopathy, anemia, obesity, substance abuse and chronic liver disease (Table 1).Compared to controls, nonagenarians were found to have shorter length of stay (-2.486 days, p
Abstract 15996: Pre-Operative Predictors of Permanent Pacemaker Implantation Post Aortic Valve Replacement: A Retrospective Cohort Evaluation
Circulation, Volume 148, Issue Suppl_1, Page A15996-A15996, November 6, 2023. Introduction:Permanent pacemaker (PPM) implantation following Aortic Valve Replacement (AVR) is common. While AVR modality choice (i.e. surgical vs. transcatheter) affects PPM risk, identifying pre-operative factors associated with increased PPM risk can benefit enhanced risk assessment and care decisions.Methods:This study is a retrospective evaluation of pre-operative factors associated with PPM risk within 1-month post-AVR at a tertiary care centre (2014-2020). Pre-AVR conduction abnormalities were classified as left bundle (LBBB), right bundle branch blocks (RBBB), and other abnormalities (left anterior/posterior fascicular block, intraventricular conduction delay) in combination with RBBB, LBBB, or alone.Results:Of the 776 (mean age= 74, 66% male) patients, 89 (11.5%) subsequently received PPM. As per pre-AVR electrocardiogram, 76 (9.8) were not in sinus rhythm and 214 (27.6%) had conduction abnormalities, including: 81 (10.4%) LBBB and LBBB + other, 91 (11.7%) RBBB and RBBB + other, and 42 (5.4%) other abnormalities. Pre-AVR rhythm (18.4 vs. 10.7%, p=0.05) and conduction abnormalities (19.2 vs. 8.5%, p