Risultati per: Stroke

Stroke, Volume 56, Issue Suppl_1, Page AWMP105-AWMP105, February 1, 2025. Introduction:Accurate prediction of the risk of ischemic stroke (IS) is vital for prevention and would be aided by multimodal biomarkers integrating genetic, clinical, and functional data. The role of imaging and EKG based atrial measurements, other than atrial fibrillation (AF), in IS prediction is uncertain and many strokes remain cryptogenic despite extensive work-up. As an exploratory step to improve stroke evaluation by including atrial traits, we developed a novel multimodal deep learning model integrating demographic and clinical variables with atrial phenotypic and genotypic data.Methods:We collected individuals from UK Biobank (UKBB) and defined ischemic stroke (IS) by the UKBB Algorithmically Defined Outcome (ADO). We developed a multimodal multi-layer perceptron with late fusion (MMLP-LF) model to predict whether a subject has IS by integrating five data modalities from UKBB: 1) MRI and EKG derived atrial traits, 2) lead genetic variants (P

Stroke, Volume 56, Issue Suppl_1, Page AWMP109-AWMP109, February 1, 2025. Introduction:During acute ischemic stroke, energy depletion leads to a rise in creatine (Cr) as a buffer, increased extracellular glutamate from impaired neurotransmitter transport, and a pH drop due to lactic acid buildup. Understanding these changes is crucial for timely intervention, yet no current method captures all these alterations simultaneously. CEST, a novel MRI technique, non-invasively maps metabolites with high sensitivity, providing information on both concentration and pH. Our group recently demonstrated guanidino CEST (GuanCEST) at 3T, reflecting Cr levels, while amine CEST (amineCEST) at 9.4T likely indicates glutamate, and amide CEST (amideCEST) correlates with pH. We aim to use these techniques to investigate metabolic, neurotransmitter, and pH changes in two mouse models of middle cerebral artery occlusion (MCAO).Methods:Ten male C57BL/6 mice (aged 3–6 months) were used for two stroke models: permanent MCAO (pMCAO, n=4) and transient MCAO (tMCAO, n=4). MRI scans were conducted at 9.4T and 3T. Diffusion-weighted imaging identified stroke lesions, followed by T1and T2mapping on the selected slice. CEST scans were performed with a 2s saturation time across B1values ranging from 0.4 to 3.0 μT. We utilized Polynomial and Lorentzian Line-shape Fitting (PLOF) to simultaneously extract GuanCEST, amineCEST, and amideCEST from the CEST spectrum at each pixel, generating corresponding CEST maps. The average CEST values in the lesion and contralateral hemisphere were analyzed.Results:At a B1of 0.4 μT, GuanCEST (Fig. 1, red line) increased by 1.01±0.19% in pMCAO compared to the contralateral hemisphere but decreased by 0.32±0.27% in tMCAO, indicating a greater Cr rise in pMCAO. At higher B1, Cr effects diminished while pH effects increased. When B1exceeded 0.8 μT, amineCEST increased by 3.86±0.42% in tMCAO, nearly four times the rise in pMCAO (1.09±0.26%), possibly reflecting neurotransmitter changes due to cell membrane polarization and energy depletion. At 1.6 μT, amideCEST decreased by 0.53±0.05% in pMCAO but remained stable in tMCAO (0.49±0.48%), suggesting greater tissue acidification in pMCAO. Similar trends were observed at 3T, except amineCEST was undetectable.Conclusion:CEST MRI is a non-invasive technique capable of mapping metabolite, neurotransmitter, and pH changes in the stroke-affected brain, with strong potential for clinical translation.

Stroke, Volume 56, Issue Suppl_1, Page ATMP17-ATMP17, February 1, 2025. Background:For optimal care and outcomes, patients must receive treatment from a multidisciplinary team approach at a comprehensive-stroke certified facility with stroke specialist units. The multidisciplinary approach increases bedside RNs engagement. The stroke team frequently performed their rounds on 4N without the bedside RN present. This does not foster trust and communication between RNs and MDs. We sought to improve the bedside RNs engagement by having multidisciplinary rounds including the bedside RN and stroke team during rounds.Smart Aim:Improve the bedside RNs team engagement with an increase of at least 1 point on the Likert scale.Implementation:We began using a simple Likert 5-point questionnaire completed by the nurses on 4N to evaluate their daily experience with stroke team rounds and their engagement with the team. The Likert questions were graded 1-5 from strongly disagree (1) to strongly agree (5). Then from April 2024 to July 2024 the nurses on 4N, joined in collaborative rounds with the stroke team daily. The RN was requested to join collaborative rounding whenever the stroke team was present on the unit. Rounding with the bedside RN included plan of care, overnight events and any issues the bedside RN wanted to inform the stroke team about. After a few months of multidisciplinary/collaborative rounding, the RNS were then asked to complete the same Likert 5-point questionnaire.Results:Looking at the Likert pretest versus the posttest the question “ I feel engaged with the stroke team during their rounds” had a pretest score of 2.7 and a post score of 4.0. Thus demonstrating, the bedside RNs felt more engagement since the implementation of rounding with the stroke team daily.Conclusion:Creating a standardized plan of care with a multidisciplinary team rounding approach for the stroke patients on 4N, increased the nurse’s engagement by at least 1 point on the Likert 5-point questionnaire. The RN felt more engaged and empowered to express patient’s needs, concerns, and felt greater collaboration with stroke team. Demonstrating that multidisciplinary rounding engages the bedside RN. Additionally, we will track&trend this data to include improved patient outcomes for stroke patients.

Stroke, Volume 56, Issue Suppl_1, Page ATP327-ATP327, February 1, 2025. Self-reported stroke prevalence has increased among US adults aged 18-64 over the past decade and is projected to rise. As younger stroke survivors live longer, access to healthcare is essential for the detection, treatment, and monitoring of cardiovascular disease (CVD) risk factors to prevent recurrent stroke or other acute CVD events. Adults aged 1 personal healthcare provider, the ability to afford to see a doctor in the past year, and a routine checkup within the past year).Most stroke survivors reported healthcare access: 86.3% (95% CI 85.7 – 86.8 had insurance coverage and >1 personal healthcare provider); 26.6% (95% CI 25.9 – 27.3) couldn’t afford a doctor in the past year; and 81.2% (95% CI 80.6 – 81.1) had a routine checkup in the past year. Statistically significant differences (p < 0.05) were found across all sociodemographic groups. Younger adults (aged 18-29 and 30-44), men, and those with lower education reported less healthcare access. Varying measures of access were reported across racial/ethnic groups.Overall, most stroke survivors reported access to healthcare, although opportunities exist to improve access for younger adults, men, different racial/ethnic minorities, and those with lower education. Prior access to healthcare might have contributed to stroke survival for some individuals. Continued and improved healthcare access could help prevent recurrent stroke or other acute CVD event among stroke survivors.

Stroke, Volume 56, Issue Suppl_1, Page AWMP113-AWMP113, February 1, 2025. Introduction:Post-stroke brain stimulation is a promising neurorestorative approach, yet the molecular mechanisms driving recovery remain unclear. Our previous work demonstrated that post-stroke optogenetic stimulations of the ipsilesional primary motor cortex (iM1) promotes functional recovery. To understand the mechanisms driving post-stroke recovery, we investigated the transcriptome of iM1 in non-stimulated and stimulated mice using RNA sequencing.Methods:C57Bl6 male mice underwent stereotaxic surgery to express Channelrhodopsin in iM1 excitatory neurons, with optical fiber implanted in the same location. After 5-6 weeks, mice underwent transient middle cerebral artery occlusion (30 minutes). Stimulated mice received optogenetic stimulations from post-stroke days (PD) 5–14. Rotating beam test was performed at pre-stroke baseline, PD4, 7 and 14. iM1 from stimulated, non-stimulated stroke mice at PD 7&15, and sham mice were processed for RNA sequencing (n=4-5/group). Expression of cholesterol enzymes such as HMGCS1 was examined using quantitative PCR and immunohistochemistry. Cholesterol levels were visualized using filipin or BODIPY.Results:iM1 stimulations enhanced recovery at PD14, with longer distance traveled and faster speed on the rotating beam test (p

Stroke, Volume 56, Issue Suppl_1, Page ATMP39-ATMP39, February 1, 2025. Obtaining consent for participation in acute stroke trials is particularly challenging due to the time pressure of delivering immediate treatment. As a result, patients are often not able to provide informed consent to participate in clinical trials. Modifications to standard consent practices such asdeferral of consent,surrogate consent,or2-physician consentcan produce problems including violating patient autonomy, disadvantaging patients through their participation and biasing results. Alternatively,advance consent, in which patients at risk of stroke consent to participate in RCTs before they experience a stroke, could address these challenges. In this study, we assessed the acceptability of advance consent to people at risk of stroke.Methods:We approached patients deemed at risk of stroke in the Stroke Prevention Clinic of the Ottawa Hospital, a tertiary care facility in Ontario, Canada. Eligible patients were invited to complete a questionnaire regarding advance consent. Patients who responded positively to questions about advance consent were offered the opportunity to consent in advance to the EASI-TOC and/or FASTEST clinical trials.Results:We screened 1547 patients over a 1-year period (July 2023 – July 2024), of whom 431 (28%) were eligible to participate. Of the 431 eligible participants, 157 (36%) completed the initial questionnaire. Of these, 96% (151/157) either agreed or strongly agreed that inviting stroke patients to provide advance consent to participate in clinical research trials is appropriate. Further, 95% (149/157) of participants either agreed or strongly agreed that they would provide advance consent to specific acute stroke clinical research trials, and 69% (108/157) either agreed or strongly agreed that they would provide advance consent to all acute stroke research trials, whether or not they were given the details of the trial. Ultimately, 123 respondents were eligible to be offered advance consent, of whom 45 (37%) provided advance consent to participate in at least one ongoing trial. One participant (0.8%) specified in advance that they would not want to participate in these trials.Discussion:Preliminary results of this feasibility study show that patients were open to the idea of providing advance consent to participate in acute stroke research and a sizable portion of patients were willing to provide advance consent for ongoing trials.

Stroke, Volume 56, Issue Suppl_1, Page ATP305-ATP305, February 1, 2025. Introduction:Acute ischemic stroke (AIS) may be associated with feelings of anxiety and/or depression (A/D) in subsequent months. The purpose of this study was to determine the frequency of feelings of A/D after AIS longitudinally and to identify risk factors that may predict post-stroke feelings of A/D.Methods:Data were collected from patients with AIS at a stroke center from 2016-2022. Patients were excluded if

Stroke, Volume 56, Issue Suppl_1, Page ATMP45-ATMP45, February 1, 2025. Background:Prior studies reported only half of stroke patients arrived at emergency departments (ED) via emergency medical services (EMS). Some studies found EMS arrival to be associated with more rapid evaluation and treatment which have been shown to be associated with better outcomes. We sought to explore ED modes of arrival for potential acute stroke patients in two large racial-ethnically diverse regional cohorts in California.Methods:Kaiser Permanente Northern California (KPNC) consists of 21 certified stroke centers, and Kaiser Permanente Southern California (KPSC) have 15 certified centers. Both regions have standardized Telestroke programs for all stroke centers to include video evaluation by a teleneurologist. From 1/1/2016 to 12/31/2022, the KPNC study cohort included all non-cancelled stroke alerts who were potential candidates for further workup for acute ischemic stroke treatment. Non-cancelled group was approximately 45% of the total stroke alert volume in the KPNC region. During the same period, KPSC study cohort included all stroke alerts who were evaluated by Telestroke for possible acute stroke. KPSC did not use a cancel-versus-non-cancel system. Assessment included demographics, ED mode of arrival, and neighborhood deprivation index (NDI).Results:During the study period, there were 17,437 patients from KPNC and 41,466 patients from KPSC yielding a combined total of 58,903 adults evaluated by Telestroke neurologists for possible acute stroke at 36 stroke centers in California. Overall, 31,533 (53.5%) arrived via walk-in rather than EMS. However, in Southern CA, patients were more likely on average, to arrive as walk-in (67.7%) compared to Northern CA (19.8%). Range of walk-in for KPNC facilities was 11% to 38.5%, and 34% to 86.1% for KPSC centers [Figure]. Patients who presented as walk-in tended to be younger and more Hispanic. Those from more impoverished communities presented via EMS more often than via walk-in [Table].Conclusions:In our combined cohort, there were several differences between walk-in patients and those who arrived via EMS. There was notable variation in ED arrival mode by facility and stark contrast between the two regions in California. Further research is needed to understand these differences and whether they are associated with outcomes, and to identify potential targets for future interventions to improve acute stroke care delivery for walk-in patients.

Stroke, Volume 56, Issue Suppl_1, Page AWP176-AWP176, February 1, 2025. Introduction:Informed consent for clinical trials in the acute stroke setting is challenging. There is a need for context-appropriate approaches to consent, but few data exist regarding implementation of innovative approaches. In the Multi-Arm Optimization of Stroke Thrombolysis (MOST) trial (NCT03735979), a consent process was designed in collaboration with patient advisors that included a short consent form and a companion information sheet. This approach was implemented at all study sites, and participants’ experiences were assessed using a post-enrollment survey.Methods:All participants enrolled in MOST were eligible for the survey. The person who provided consent for enrollment (patient or surrogate) was asked to fill out the survey. The survey was adapted from a prior survey of patients’ and surrogates’ experiences with consent in acute care research and was cognitively pre-tested. Descriptive statistics were tabulated. Likert scale responses on a scale of 1-5 with 1 being strongly agree and 5 being strongly disagree and on a scale of 1-5 with 1 being extremely helpful and 5 being not helpful at all were collapsed into agree (1-2)/not agree (3-5) and helpful (1-2)/not helpful (3-5), respectively.Results:There were 195 completed surveys out of 514 enrollments in the MOST trial (overall capture rate 37.9%). Seventeen surveys were excluded due to mismatch between who consented to MOST and who completed the survey (total n=178 analyzable surveys). Patients completing the survey (or for whom a surrogate completed the survey) were similar to the overall enrolled population in terms of age, sex, race, and stroke severity (Table 1). The average age of survey respondents was 60.1 years, with 42.1% being male and 61.8% being surrogates (Table 2). Overall patients’ and surrogates’ experiences were positive. Post-enrollment communication and consent materials were viewed favorably (Table 3). Open-ended feedback was positive; participants acknowledged that time stress was intrinsic to the situation, encouraged simplicity, and offered few suggestions for improvement.Conclusions:A patient-centered consent process in an acute stroke trial was positively viewed by both patients and surrogates. Embedding assessments of patients’ and surrogates’ experiences within clinical trials offers an important opportunity for understanding the impact of innovation regarding consent.

Stroke, Volume 56, Issue Suppl_1, Page ATMP42-ATMP42, February 1, 2025. Background:Ischemic strokes occur due to a blood supply blockage in one of the brain’s blood vessels, and Hemorrhagic strokes occur when one of the brain’s blood vessels ruptures. The American Stroke Association cites strokes as the fifth leading cause of death in the United States. This study aimed to determine the average minutes needed for patients to achieve their Medicare-calculate goals at our inpatient rehabilitation program.Methods:A retrospective study of 393 patients with stroke (age >18: 209 men, 184 women) that received either 3 hours of therapy 5 days per week or 2 hours and 20 minutes of therapy 7 days a week for the length of their stay in our program from January 2021-December 2023.Results:Main outcome measures were the Medicare calculated self-care and mobility scores on admission and on discharge. 283 patients met at least one of their Medicare calculated discharge goals. Those that met their self-care goals needed less PT, OT, and ST minutes. They also had a higher AMS than those that did not meet their self-care goals. Those that met their mobility goals required more PT, OT, and ST minutes, and had a higher AMS than those that did not meet their mobility goals. Those that met both their self-care and mobility goals required more PT and OT minutes, less ST minutes, and had a higher AMS.Discussion:ST minutes were an independent predictor of whether people would meet their self-care goal. Patients with higher BMIs were not likely to meet their mobility goal. Patients with a higher AMS were more likely to meet their mobility goal. BMI and AMS were independent predictors of whether people met their mobility goal. There were no independent predictors as to whether patients would meet both their self-care and mobility goals. Those achieving theirself-care goalneeded an average of 831.5 minutes (PT), 826.8 minutes (OT), and 397.2 minutes (ST). Those achieving theirmobility goalneeded an average of 845.8 minutes (PT), 833.7 minutes (OT), and 403.8 minutes (ST). Those achieving both theirself-care and mobility goalsneeded an average of 835.5 minutes (PT), 830.3 minutes (OT), and 417.1 minutes (ST).Conclusion:Stroke patients are more likely to meet their Medicare-required self-care goals if they require less ST minutes. Patients with a higher BMI and lower AMS score are less likely to meet their Medicare-required mobility goals. There was not an independent predictor for patients that met both their self-care and mobility goals.

Stroke, Volume 56, Issue Suppl_1, Page ATP300-ATP300, February 1, 2025. Background:Coffee is one of the most widely consumed beverages in the world, and contains caffeine in it. Previous pre clinical studies and meta analysis have shown conflicting results with majority supporting that coffee consumption was associated with lower risk of stroke.Objective:This study aims to investigate the association between coffee consumption and risk of stroke.Methods:We performed a systematic literature search on PubMed, EMBASE, and ClinicalTrials.gov for relevant studies from inspection until August 10th, 2024, without any language restrictions. Risk ratios (RR) and 95% confidence intervals (CI) were pooled using a random-effect model, and a p-value of 4 cup of coffee/day were having higher odds of all stroke (RR, 1.33(95%CI: 1.05-1.67). However, there was no such association between low to moderate (1-3 cup) coffee consumption and stroke risk (RR, 1.24(95%CI: 0.94-1.64).Conclusion:High coffee consumption was associated with higher risk of stroke, however not with low to moderate coffee consumption. It can help individuals who are addicted to more coffee drinking/day to avoid stroke risk.

Stroke, Volume 56, Issue Suppl_1, Page AWMP104-AWMP104, February 1, 2025. Introduction:Post-Civil War, Richmond emerged as a major center for tobacco cultivation and manufacturing, driven by its exploitation of Black labor. Laborers were often employed in physically demanding positions in unventilated and smoke-filled environments, coupled with forced residence in undesirable neighborhoods due to historic redlining. In response, Black laborers organized strikes leading to lower working hours, increased wages, and improved workplace safety. We investigated whether these changes in social determinants of health (SDOH) may have contributed to the reduction in stroke mortality among Black workers in Richmond in the 20thcentury.Methods:Data was sourced from the Richmond Cemetery Collaboratory (RCC), which digitized Black Death Records in Richmond, Virginia. Death records were ICD-10 coded by ChatGPT. A total of 1,815 death records (1907-1979), were georeferenced based on their proximity to tobacco factories. We conducted hotspot analysis across the study period to assess stroke mortality across time and space. The age distribution of stroke deaths within the period was compared to the 1940 Vital Statistics, which documented stroke mortality for all non-white races.Results:Stroke mortality in RCC data significantly declined following the period of labor activism between 1937 and 1941. Hot spot analysis revealed a geospatial shift in stroke mortality in Richmond, moving from the east side in the early 1900s to the south side in the mid-1900s (Figure 1A). The stroke mortality rate within a 1 km radius of tobacco manufacturing plants was 109.46 per 100,000. The observed K value indicated high levels of stroke death clustering within the sample, likely due to historic redlining (Figure 1B). Additionally, stroke mortality was more common among individuals

Stroke, Volume 56, Issue Suppl_1, Page ATMP13-ATMP13, February 1, 2025. Background:Stroke education plays a critical role in improving the public’s awareness of stroke and identifying stroke symptoms, ultimately reducing the morbidity and mortality associated with stroke. While health fairs are a common venue for such education, expanding efforts beyond these events may reach a broader audience. This abstract explores the advantages of providing stroke education in diverse settings.Methods:A Systems of Care Model was utilized for community stroke education which involved coordinating outreach efforts by key stakeholders within a large healthcare system. This approach was developed to ensure comprehensive and effective stroke education was presented to community members in everyday environments. BEFAST was discussed to provide education on the signs and symptoms of stroke, activation of 911, along with modifiable and non-modifiable risk factors. By integrating stroke education into everyday environments, a culture of continuous learning where stroke awareness becomes part of routine conversations, rather than a once -a-year event. This approach allows tailored messages that are specific to the needs of the communities, addressing unique risk factors and cultural considerations that otherwise would not be addressed in the traditional delivery of community stroke outreach.Results:Over 5,000 individuals were educated throughout the year ranging from children to senior citizens. Individualized education was provided to meet the unique needs of each audience and environment across a wide range of diverse settings, which included the service industry, sales, sporting events, religious congregations, magazine advertisements, and other media. Rapport was established during initial individual interviews in these settings resulting in follow-up visits providing personalized stroke education. Feedback from the community suggested the education was effectively delivered for stroke symptom and risk factor recognition. Personal accounts were shared by eight (8) community members who then sought emergency care for stroke symptoms either for themselves, co-workers or family members.Conclusions:Expanding stroke education beyond health fairs is a strategic approach to engage a larger proportion of our community. This proactive approach has the potential to improve early detection and treatment outcomes, ultimately reducing the long-term impact of stroke on individuals and communities.

Stroke, Volume 56, Issue Suppl_1, Page ATMP49-ATMP49, February 1, 2025. Background and Objective:A stable perfusion pattern may guarantee a good clinical outcome in acute stroke patients. This study aimed to explore the differences of perfusion patterns over the acute phase in acute stroke patients with different etiologies.Methods:This study included acute ischemic stroke patients who arrived at Huashan Hospital, Fudan University within 24 hours of last known normal. All patients underwent baseline multimodal CT scan (including CT angiography [CTA] and perfusion imaging), and had confirmed large vessel occlusion or severe stenosis of anterior circulation. Recanalization status was evaluated through follow-up perfusion or angiography imaging. Final infarct volume (FIV) was assessed by follow-up CT or magnetic resonance imaging within 7 days after arrival. Penumbral stability was assessed using the Perfusion-Infarct Index (PFI)，which was defined as 1 – (FIV – baseline infarct core) / baseline penumbra. For patients without recanalization, a stable penumbral pattern was defined PFI > 0.9. Kaplan-Meier survival curve analysis was used to explore the difference of PFI between patients with cardioembolic (CE) and large artery atherosclerotic (LAA) etiology during the acute phase. For patients without recanalization, stepwise logistic regression analysis was conducted to identify independent predictors of a stable penumbral pattern.Results:A total of 250 acute ischemic stroke patients were included, with 160 classified as LAA-related stroke and 90 as CE-related stroke. Kaplan-Meier survival curve analysis revealed that LAA-related stroke patients had a higher PFI value compared to CE-related stroke patients throughout the acute phase (P=0.02). Of the 88 patients who did not achieve recanalization, patients with LAA-related stroke were more likely to have a stable penumbral pattern compared with patients with CE-related stroke (39% vs. 10.3%, P=0.01). Stepwise logistc regression analysis demonstrated that baseline NIHSS ≤8 (OR: 8.8, 95% CI: 2.9 – 26.4, P

Stroke, Volume 56, Issue Suppl_1, Page ATMP27-ATMP27, February 1, 2025. Background:In 2022, stroke shifted from the fourth to the fifth leading cause of death in the U.S. as COVID-19 temporarily took its place. Despite this change, stroke remains a significant cause of mortality and long-term disability in the U.S. This study analyzes trends in in-hospital mortality among stroke-related hospitalizations in California from 2016 to 2022, with a particular focus on the pandemic years.Methods:This retrospective analysis utilized patient discharge data from the California Department of Health Care Access and Information, screening nearly 25 million inpatient events for stroke-related ICD-10-CM diagnosis codes (I60-I63) among individuals 20 and older. Multivariate logistic regression (MLR) analysis assessed the impact of the pre- and post-COVID-19 periods on in-hospital mortality, adjusting for confounders such as age, gender, race and ethnicity, geographic regions, and payer source. Results were interpreted using Adjusted Odds Ratios (AOR).Results:The study identified 590,801 stroke-related hospitalizations and 66,096 in-hospital deaths (11.2%). Initially, the age-and-sex-adjusted in-hospital mortality rate decreased from 28.88 per 100,000 in 2016 to 27.38 in 2019. However, with the onset of COVID-19 in 2020, the rate increased to 27.94, peaking in 2021 at 30.78 during the pandemic’s height. In 2022, the rate slightly declined to 28.30 but remained above pre-pandemic levels.Similar trends from 2016 to 2022 were observed in age-adjusted rates for males, which increased from 27.77 to 29.73, and for females, which decreased from 29.91 to 26.98. The gap between male and female mortality rates widened significantly during the pandemic, with male mortality peaking in 2021 with a difference of 3.75.MLR analysis revealed a 22.6% increase in in-hospital mortality during the post-COVID period compared to the pre-COVID period (AOR=1.23, p

Stroke, Volume 56, Issue Suppl_1, Page ATP323-ATP323, February 1, 2025. Introduction:Hypertension is one of the leading causes of mortality. The direction and strength of the association between death from hypertensive and hypertensive renal disease and stroke mortality during the COVID-19 pandemic among different U.S. ethnic groups is unclear.Hypothesis:Hypertensive and hypertensive renal disease mortality is positively correlated with increased stroke death overtime during the COVID-19 pandemic. We aim to examine the correlation between mortality from Hypertensive and hypertensive renal disease and stroke before and after the COVID-19 pandemic among U.S. Hispanic and non-Hispanic populations.Methods:A database query from the U.S. Centers Disease for Control and Prevention (CDC) Wonder was retrieved. A yearly age-adjusted mortality from hypertension or hypertensive renal disease from 2017 to 2022 was correlated with the mortality from stroke by Pearson’s correlation coefficient. Further analyses were performed by stratified data before and after 2019 as well as among Hispanic and non-Hispanic subgroups.Results:Age-adjusted mortality from hypertension and hypertensive renal disease trended down before the COVID-19 pandemic (from 9 to 8.91 deaths per 100,000 populations) but trended up after the pandemic (from 10.08 to 10.29 deaths per 100,000 populations). A similar trend occurred in age-adjusted mortality from stroke (from 37.59 to 36.59 deaths per 100,000 populations during pre-pandemic and from 38.84 to 39.53 deaths per 100,000 populations during post-pandemic). Those overall cause-specific mortalities are highly correlated with the correlation coefficient of 0.9697 (Figure 1). The correlation remained but slightly attenuated among Hispanics, while more pronounced among non-Hispanics (0.9649 and 0.9680, respectively; Figures 2 and 3). Stratified by time-related to the COVID-19 pandemic, age-adjusted mortality from hypertension and hypertensive renal disease and stroke trended down before the COVID-19 pandemic but trended up after the pandemic. The correlation was 0.9866 before the pandemic and up to 0.9988 during the pandemic (Figures 1, 2, and 3).Conclusions:Hypertensive and hypertensive renal disease mortality as well as stroke mortality have trended up and increased during the COVID-19 pandemic, particularly among the non-Hispanic population. Further investigations are required to mitigate health and ethnic disparities, especially during high demand for limited resources.