Sound of Science: il futuro cambia musica. VideoReportage di PharmaStar [Business]

L’evento “Sound of Science” ha riunito istituzioni e stakeholder che hanno condiviso proposte per una sanità più sostenibile e innovativa. Al centro, l’urgenza di superare modelli frammentati per abbracciare un approccio integrato basato su dati, intelligenza artificiale e collaborazione pubblico-privato. Il VideoReportage con 13 videointerviste e i dati dell’indagine “Scienza e salute: la voce dei giovani”, esplora criticità e potenzialità del sistema ricerca, lanciando un messaggio chiaro: costruire oggi Sanità del futuro equa, accessibile e orientata all’innovazione.

Read More

Randomized, Proof-of-Concept Trial (RESCUE) of RNS60 as an Adjunct Therapy in Acute Ischemic Stroke

Stroke, Ahead of Print. BACKGROUND:Despite significant improvements in early reperfusion, many patients with acute ischemic stroke with large vessel occlusion experience poor outcomes, which indicates a clear need for adjunct therapies. RNS60 is a proprietary combination of oxygen supersaturated in saline with cerebroprotective and immunomodulatory effects. RNS60 showed therapeutic promise in rodent and nonhuman primate models of acute ischemic stroke. RESCUE was the proof-of-concept trial testing adjunctive treatment with RNS60 in patients with acute ischemic stroke with large vessel occlusion undergoing endovascular thrombectomy with or without prior treatment with an intravenous thrombolytic.METHODS:This randomized multicenter, placebo-controlled, double-blind, phase 2 study enrolled 82 participants, assigned 1:1:1 to 48-hour infusion of RNS60 0.5 mL/kg per hour, RNS60 1.0 mL/kg per hour, or placebo 1.0 mL/kg per hour, and followed for 90 days. Rates of serious adverse events and mortality were the primary end points. Efficacy end points included the modified Rankin Scale score, infarct volume growth, National Institutes of Health Stroke Scale, worsening of stroke, Barthel Index, and the EuroQoL health-related quality of life scale.RESULTS:The RNS60 groups met the primary end points with similar rates of serious adverse events (33.3%, 25.0%, and 28.6%) and fewer deaths (6.7%, 8.3%, and 14.3%) across RNS60 0.5 mL/kg per hour, RNS60 1.0 mL/kg per hour, and placebo, respectively. The RNS60 1.0 mL/kg per hour group showed reduced infarct growth by 47% at 48 hours post–endovascular thrombectomy (21.4 mL [interquartile range, 5.0–29.1] versus 40.6 mL [interquartile range, 6.3–62.3];P

Read More

[News] Royal College of Obstetricians & Gynaecologists (RCOG) World Congress

The RCOG World Congress 2025 took place at the London ExCeL Centre on June 23–25, hosting over 2500 delegates from around 100 countries and delivering over 70 sessions with more than 220 global speakers. Under the theme of “Equity in care, innovation in action”, the programme covered an impressive range of topics, relevant to both UK and global audiences, including women’s health (eg, menopause, sexual health, inequalities in access to care, cancer, endometriosis, vulval disease, human papillomavirus (HPV) vaccination, and imaging in gynaecology), fertility and reproduction (eg, developments in assisted reproduction, abortion, and contraception), and pregnancy and post-partum care (eg, preterm birth, obstetric fistula, foetal imaging, and postpartum complications), as well as the emerging role of artificial intelligence (AI) and digital health across these topics.

Read More

Beyond Screen Time—Addictive Screen Use Patterns and Adolescent Mental Health

Screen use, the time spent engaging with electronic devices such as mobile phones and tablets, can become addictive when individuals experience difficulty stopping despite attempts to do so, as well as symptoms of withdrawal, tolerance, conflict, and relapse (BoxBox). Adolescence is a vulnerable period for addictive behaviors, and recent findings suggest that young adolescents are particularly susceptible to screen addiction. Notably, in the US, 48% of young adolescents report losing track of how much they are using their phone, 25% use social media to forget about their problems, and 25% admit to spending a considerable amount of time thinking about social media apps. Furthermore, 17% have tried to reduce their social media use but cannot, and 11% acknowledge that their screen use has negatively affected their schoolwork. These statistics highlight the need to study screen addiction and its specific health effects, as understanding these behaviors is crucial for addressing the risks they pose to adolescents’ well-being.

Read More

Addressing Inaccuracies in American Indian and Alaska Native Health Data Is a Work in Progress

In this issue of JAMA, Bor et al address the undercounting of deaths among American Indian and Alaska Native (AI/AN) individuals through data from Mortality Disparities in American Communities, a study that included linkage of self-identified race and ethnicity from the 2008 American Community Survey to death certificates from the National Vital Statistics System. The authors measured substantially increased rates of AI/AN mortality after correction for race and ethnicity misreporting on death certificates. The study constitutes a critical addition to a growing body of literature illustrating that Indigenous Peoples, already recognized as having among the highest mortality rates and shortest life expectancies of US populations, have yet worse health outcomes than previously available data suggest.

Read More

What Makes Data Meaningful

As the frontiers of health care expand, research published in medical journals like JAMA often features large-scale, international, multicenter trials and far-reaching topics, such as genomics and artificial intelligence. However, the need for individual participants to constitute vast datasets remains foundational. Tapping poetry’s capacity for expressing the uniqueness of voice and engendering empathy, the poem “Death equals one” invites readers to reflect on what makes scientific inquiry so valuable by doing something that it intentionally does not: humanize a piece of data. The poem depicts a lone epidemiologist as she studies a data point. She fixates on this “single line in the database,” initially seeing it as merely helpful information for her research. As we read, however, poetry allows us to learn more about who this data point actually is. In this poetically informed, unmasked world, both we and the speaker are humanized also. Vivid details like “never a math person” and “frail silhouette” breathe life into a person in our minds beyond “a mere string of figures.” Our materializing image of this multidimensional, not-so-hypothetical participant further contrasts with the simple equation comprising the poem’s title. The poem challenges us to remember the human beings behind the data points that we code, analyze, read, or write about. Here, poetry, in perhaps the unlikeliest of places, serves as a humbling reminder that each study participant entrusts a piece of themselves to us, to be safely and anonymously, and yet indelibly, “one among thousands” in the pursuit of inspired science.

Read More

ANMAR protagonista al Congresso EULAR 2025: tra equità di accesso, medicina di genere e remissione secondo il paziente [Ortopedia e Reumatologia]

Anche quest’anno ANMAR – Associazione Nazionale Malati Reumatici – ha partecipato con un ruolo da protagonista al Congresso EULAR (European Alliance of Associations for Rheumatology), portando a Barcellona la voce dei pazienti reumatologici italiani e riaffermando l’impegno costante verso un sistema sanitario più equo, moderno e centrato sulla persona. Tre i poster scientifici presentati: due a firma ANMAR – uno dei quali elaborato in collaborazione con il nostro Osservatorio “Capire” (Avv . Patrizia Comite e Prof. Mauro Galeazzi) e ANMAR Young – e un terzo in partnership con altre associazioni nell’ambito del progetto “Genere Donna”. In primo piano, temi cruciali come la promozione della medicina di genere, l’empowerment delle pazienti e l’equità di accesso alle cure per chi convive con patologie autoimmuni come Artrite Reumatoide (AR) e Artrite Psoriasica (PsA).

Read More