Risultati per: Guida allo screening del cancro del colon-retto

Top Ten US Cancer Centers make screening recommendations inconsistent with those of the USPSTF recommendations, with cancer centers generally recommending more screening and omitting a nuanced discussion of benefits and risks. Given the national and international reputation of these cancer centers, their recommendations can have important population level implications, including confusion in the public.

Durante la tappa fidardense dell’iniziativa Incra-Croce rossa

Con screening 159 decessi in meno all’anno per diagnosi tardiva

Dalla scuola al welfare aziendale fino alla vita nei borghi

This study employed several novel processes to establish an ML model with probability-scores superior to predictions of disease likelihood by specialists. However, the negligible improvement in interpretations by specialists after provision of probability-scores indicates this alone is insufficient to improve decision-making.

Objectives
To establish whether sports-branded screening is effective in identifying adults at risk of developing cardiovascular disease (CVD); to determine whether the public would engage with sports-branded health screening and what their experiences were.

Design
Convergent parallel mixed methods.

Setting
Mass screening at Liverpool Football Club Foundation events at four community centres.

Participants
100 participants (mean age 46.6 years (SD 14.7), range 20–84 years) were recruited, and their risk factors were identified. Of these, 62 were screened for their SCORE 2 CVD risk. Men and women were equally represented. Participants were predominantly white British (93%).

Interventions
A dedicated screening area was established at each venue. Data to calculate SCORE 2/OP risk scores were captured (gender, smoking status, age, blood pressure and lipids). Additional risk factors (glucose, incident atrial fibrillation and body mass index (BMI)) were measured to assess wider heart health. A purposive sample of 12 participants participated in a semistructured, one-to-one audio recorded interview about their experience.

Primary and secondary outcome measures
Outcomes were the SCORE 2 and SCORE 2/OP risk tool; ability to recruit participants and whether sports-branded screening was acceptable to participants.

Results
Participants ranged from 20 to 84 years with a mean age of 46.6 years. Men and women were equally represented. Participants were predominantly white British, with 41% and 40% recording a higher than normal total cholesterol and low-density lipoprotein cholesterol (LDL-C) level, respectively, and 36% recording lower than normal LDL-C level. 20% of participants recorded a blood pressure greater than 140/90 mm Hg and 21% of participants were smokers. Mean BMI was 29, ranging from 17.8 to 51, with 70% of the participants classified as overweight or obese. CVD risk ranged from

Annals of Internal Medicine, Ahead of Print.

Annals of Internal Medicine, Ahead of Print.

Introduction
Cervical cancer remains a significant public health concern in Singapore, with current screening rates at 43%, well below the national target of 70%. In 2019, human papillomavirus (HPV) DNA testing was introduced into the national cervical cancer screening programme, but barriers to participation include embarrassment, privacy concerns and discomfort with clinician-sampled tests. Self-sampled HPV DNA testing offers a promising alternative by providing more privacy and convenience. This study aims to evaluate the impact of including self-sampled HPV DNA testing as an alternative to clinician-sampling on screening uptake, clinical outcomes and cost-effectiveness in primary care.

Methods and analysis
This pragmatic, open-label, two-arm randomised controlled trial employs a Zelen design. A total of 650 women aged 30–69 who are due for cervical cancer screening will be recruited from National Healthcare Group Polyclinics in Singapore. Participants will be randomly assigned to either the intervention arm (offering both self-sampling and clinician-sampling) or the usual care arm (clinician-sampling only). The primary outcome is the proportion of participants in each arm detected with high-risk HPV. Secondary outcomes include the proportion of participants in each arm who undergo cervical cancer screening (uptake), are referred for colposcopy and are detected with CIN 2/3 or cervical cancer, as well as cost-effectiveness. Acceptability and feasibility of self-sampling will be evaluated through post-screening questionnaires.

Ethics and dissemination
Ethical approval was granted by the National Healthcare Group Domain Specific Review Board. Study results will be disseminated through peer-reviewed journals, healthcare conferences and shared with policymakers to guide potential inclusion of self-sampling in Singapore’s national cervical cancer screening programme. Findings from this trial will provide crucial evidence for the potential inclusion of self-sampling in Singapore’s national cervical cancer screening programme, which could increase screening rates and improve public health outcomes.

Trial registration number
ClinicalTrials.gov: NCT06528184.

To the Editor A recent study about newborn screening using genome sequencing for early actionable conditions highlighted the potential of early detection for actionable genetic disorders. However, genomic sequencing is a “double-edged sword,” providing substantial benefits while introducing complex challenges related to technology, ethics, and privacy.

In Reply The comments from Dr Wu and colleagues regarding our recently published article highlight important technical, clinical, and ethical considerations in the use of genomic sequencing for newborn screening.

Comunità Sant’Egidio, ‘opportunità concreta per migliorare accesso alle cure’

Un documento e tre cortometraggi per dare loro voce. ‘Più cura, più tempo, più vita’, da case manager a sessualità

Con un prelievo, in Italia colpisce 20.000 bambini e adolescenti

Studio, una bevanda al giorno aumenta il rischio di 5 volte