Autore/Fonte: Mayo Clinic
Identificata una nuova immunoterapia mirata per il cancro ovarico
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24 Aprile 2025
Questo è quello che abbiamo trovato per te
Autore/Fonte: Mayo Clinic
Autore/Fonte: Università di Umea in Svezia
Autore/Fonte: Circulation
Il ministro: “Stiamo lavorando per includere quello al polmone”
Il ministro: “Stiamo lavorando per includere quello al polmone”
Our findings show that these TDA-based approaches are highly cost-effective for the vulnerable group of children hospitalised with SAM, compared to current practice.
Objective
To develop a rapid screening tool for the identification of frailty in medical calls and other out-of-hospital acute care services.
Design
Development study based on cross-sectional data. A set of potential items were developed based on existing frailty tools and other relevant literature by a panel with geriatric and primary care expertise. The items and the Clinical Frailty Scale (CFS) were administered on a convenience sample of older urgent care patients. Further development of the tool was based on statistical analyses of this data material and final discussions in the panel.
Setting
Urgent care centre in Norway, data collected between January and August 2022.
Participants
All patients ≥70 years were eligible for inclusion, with the exception of patients triaged to the highest urgency level and patients not able to answer questions with no next of kin present.
Primary outcome
Potential items associated with frailty by CFS, measured by explained variance (adjusted R2 values from linear regression analyses).
Results
Nine potential items were developed and administered on 200 patients (59% female), of whom 48% were 70–79 years, 38% were 80–89 years and 14% were ≥90 years. The median CFS score was 4 (living with very mild frailty). Receiving help weekly, being homebound and using a walking aid were identified as strong indicators of frailty (adjusted R2 values 59%, 48% and 43%, respectively). Together these three factors could explain 74% of the variation in CFS scores.
Conclusions
Receiving help weekly, being homebound and using a walking aid are strong indicators of frailty among urgent care patients. We developed a frailty screening tool for medical calls—FastFrail—consisting of three simple, binary questions (yes/no) on these aspects. We hypothesise that FastFrail can supplement traditional symptom-based triage and enable more accurate assessment of older adults calling for acute medical help. We intend to test the tool in clinical practice.
Autore/Fonte: Journal of Clinical Oncology
All’Ast di Fermo un nuovo mammografo hi-tech
In a country as wealthy as the US, it is unfathomable and heartbreaking that so many continue to be food insecure (that is, they do not have access to sufficient food, or food of an adequate quality, to meet their basic needs). Recent data from 2023 demonstrate that 13.5% of US households experience food insecurity. Food insecurity is a direct result of economic instability and highly correlated with poverty. Due to the persistent effects of structural racism, minoritized groups, including American Indian/Alaska Native, Black, and Hispanic individuals, are more than twice as likely to have food insecurity than White populations. Those most vulnerable and marginalized, including children, older adults, individuals who identify as LGBTQ+, veterans, and adults with disabilities, are also at higher risk. Clearly, food insecurity does not affect everyone equally in US society.
This 2025 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for food insecurity on health outcomes in the primary care setting (I statement).
This Medical News article is an interview with Alexander J. Blood, MD, MSc, about the potential for AI to help screen patients for clinical trials, and why more efficient study enrollment could ultimately mean better real-world outcomes for patients.
This JAMA Patient Page describes food insecurity, its health effects, and the pros and cons of screening for food insecurity in the primary care setting.
This Viewpoint highlights primary care–based screening for food insecurity as the first social determinant of health topic to be addressed by the US Preventive Services Task Force; the potential benefit of food insecurity screening on access to other preventive services; and several challenges to making a recommendation for food insecurity screening.
This study examines whether hepatitis C virus screening differs among pregnant and nonpregnant women.
Autore/Fonte: CMAJ