Risultati per: Ipertrofia prostatica benigna (IPB) (Adenoma Prostatico)

While the adenoma detection rate (ADR) is associated with post-colonoscopy colorectal cancer (PCCRC) risk, it is unknown to what extent this reflects missed colorectal cancer (CRC) versus missed pre-cancerous lesions. We evaluated the association between physician ADR and prevalent CRC detection during colonoscopy.

H. pylori infection may represent a significant risk factor for the development of colorectal cancer. The effect of anti-H. pylori treatment on colorectal cancer incidence and mortality necessitates further investigation through large-scale, randomized controlled trials with prolonged follow-up durations.

In Reply We appreciate the valuable feedback provided by the authors of the Letters regarding our study on the association between ADR and postcolonoscopy CRC incidence. Their comments highlight important points about quality metrics in colonoscopy, methodological differences, and potential areas for further investigation. Below, we address the key issues raised.

To the Editor The recent study by Dr Pilonis and colleagues explored the association between adenoma detection rate (ADR) and risk of colorectal cancer (CRC) after colonoscopy. The authors provided evidence supporting ADR as a critical quality benchmark for CRC prevention. They demonstrated that an improved ADR over time was associated with lower CRC risk in patients who underwent colonoscopy, but this association was observed only among patients whose physician had a baseline ADR of less than 26%.

To the Editor The study by Dr Pilonis and colleagues, examining the association between physician ADRs and postcolonoscopy CRC incidence, offers important insights into quality metrics for colonoscopy.

We read with great interest the study by O’Sullivan et al,1 examining the technical and procedural outcomes of Cold Endoscopic Mucosal Resection (C-EMR) versus Hot EMR (H-EMR). We congratulate the authors for conducting this important research, which adds valuable information to the body of knowledge guiding our choice of the optimal treatment modality for large, benign colorectal polyps. However, we would like to address several points. First, readers should be aware that this study focuses on a highly selected group of large non-pedunculated colon polyps (LNPCPs) as only 20% of referred lesions during the study period of 4 years met the inclusion criteria, being flat lesions of 15–50 mm, without macronodule, depressed area or optical suspicion of submucosal invasive cancer (SMIC). Despite this selection, 2.2% unrecognised SMIC was found, all of which were not curatively treated by piecemeal resection and required additional surgery. This underscores the relative performance…

This observational study investigates the association of adenoma detection rates among physicians who perform colonoscopy and postcolonoscopy colorectal cancer incidence.

Objectives
Serrated polyps (SPs) with synchronous advanced adenoma (AA) may increase the incidence of colorectal cancer. However, current studies do not address this combination of SPs and AAs in detail with regard to their clinical characteristics in different age groups. The aim was to assess clinical characteristics and risk factors for SPs with synchronous AA in different age groups.

Design
Retrospective cohort study.

Setting
Electronic medical record data from January 2011 to January 2022 at three grade III class A hospitals were enrolled in the study.

Participants
A total of 1605 patients with SPs with synchronous AA, including 484 patients in the elderly group and 1121 patients in the non-elderly group, were studied.

Main exposure measure
The elderly group and the non-elderly group.

Main outcome measure
Sex, smoking history, drinking history, body mass index (BMI), SP location, size, morphology and pathology.

Results
The incidence of hyperplastic polyps (HPs) with synchronous AA in the elderly group was higher than that in the non-elderly group, while the incidence of sessile serrated adenomas/polyps (SSAs/Ps) with synchronous AA in the non-elderly group was higher than that in the elderly group. Male sex, drinking history and HP size (≤20 mm) were independent risk factors for HPs with synchronous AA in the non-elderly group, while drinking history and HP size (≤15 mm) were independent risk factors in the elderly group. For SSAs/Ps with synchronous AA, male sex, smoking history, drinking history, and SSA size (≥16 mm) were independent risk factors in the non-elderly group; high BMI was an independent risk factor in the elderly group.

Conclusions
SPs with synchronous AA showed different clinical characteristics and risk factors in different age groups.

Objective
Whether varying degrees of glycaemic control impact colonic neoplasm risk in patients with diabetes mellitus (DM) remains uncertain.

Design
Patients with newly diagnosed DM were retrieved from 2005 to 2013. Optimal glycaemic control at baseline was defined as mean haemoglobin A1c (HbA1c)