Exploring a panel of serum biomarkers for cancer risk in patients with non-specific symptoms: a comparative analysis of feature selection methods
Objectives
Delays in cancer diagnosis for patients with non-specific symptoms (NSSs) lead to poorer outcomes. Rapid Diagnostic Clinics (RDCs) expedite care, but most NSS patients do not have cancer, highlighting the need for better risk stratification. This study aimed to develop biomarker-based cl…
Nighttime Light Exposure Associated With Increased Cardiovascular Risk
Greater nighttime light exposure may increase the risk of cardiovascular disease, according to a recent large study published in JAMA Network Open.
Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota
Background
The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn’s disease (CD) and beneficial to UC. However, the mechanisms underlying these opposite effects remain unclear.
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Exposome project for health and occupational research night shift cohort (EPHOR-NIGHT): a unique resource to advance research on night shift work and chronic disease
Purpose
The EPHOR-NIGHT cohort was established to investigate how night shift work influences biological pathways and chronic disease risk using a comprehensive working-life exposome approach, focusing on cardiometabolic, mental health, cognitive and biological ageing outcomes.
Participant
The coho…
TXI Raises Detection of Non-Neoplastic Polyps Without Improving Clinically Meaningful Neoplasia Endpoints
We read with great interest the randomized controlled trial by Toyoshima et al,1 evaluating texture and color enhancement imaging (TXI) vs white-light imaging (WLI) in colorectal cancer screening. The study’s large sample size, multicenter design, and attention to both adenoma and polyp detection a…
Reconsidering Genomic Stability in Esophageal Cancer Stem Cells: Insights from Chromothripsis
The study by Xian et al1 provides insights into the stem cell origins and evolutionary dynamics of esophageal adenocarcinoma (EAC). The authors assert that the genomic stability observed in their cultured clones, even from high-grade dysplasia and EAC, reflects inherent stability of cancer stem cel…
Sommelier
A look of disappointment, then anger, then resignation, when I told her that candles were a fire hazard in a hospital room. She asked me, voice battling through the stream of oxygen blasting on her face, and between wheezes so loud I could almost hear them from across the room, “What else will you …
Iperacusia e disfunzione dell’Articolazione Temporo Mandibolare
Iperacusia – L’iperacusia è una sensibilità eccessiva ai suoni, non un’udito eccezionalmente acuto, in cui i rumori quotidiani possono provocare fastidio, dolore o ansia. Questo fenomeno è legato a un’anomalia nella percezione e nell’elaborazione sonora da parte del ce…
L’uso della sigaretta elettronica aumenta il rischio di ulcera peptica
Notizie dalla RicercaUn ampio studio presentato al convegno scientifico annuale dell’American College of Gastroenterology, 24-29 ottobre 2025; Phoenix, ha...
L’AI individua le cellule tumorali in 10 minuti, rivoluzionando le biopsie liquide
Intelligenza Artificiale in MedicinaI ricercatori della USC hanno creato l’algoritmo RED (Rare Event Detection), uno strumento di IA che automatizza il rilevamento...
New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance
This cohort study evaluates the distribution of serum free light chains and free light chain ratios in individuals with preserved kidney function and proposes revised reference intervals and a new definition of light chain monoclonal gammopathy of undetermined significance.
Disparities in Trends of Gastroenteropancreatic Neuroendocrine Tumor Incidence—Reply
In Reply We read with great interest the letter by Dr Yu et al shedding light on sex and age disparities of patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). While we agree with the authors that comparing the incidence rates and trends based on sex and age is of value, the aim …
Lessons Learned From Drug Decriminalization Remedies in British Columbia
In light of a continuing public health emergency resulting from dramatic increases in drug-related deaths during the past 25 years, the seemingly impenetrable wall of universal prohibition laws criminalizing, among other things, possession and use of psychoactive drugs (other than alcohol and canna…
I rischi per la salute delle sigarette elettroniche
Notizie dalla RicercaUn’analisi condotta dalla Johns Hopkins Medicine sui dati medici raccolti su un gruppo eterogeneo di quasi 250.000 persone nell’arco...
Strategie e criteri per la diagnosi e la gestione della miocardite
CardiovascolareQuesto documento fornisce le linee guida dell’American College of Cardiology (ACC) sulla diagnosi e la gestione della miocardite, con un...
Gli indicatori di un cervello che invecchia
CardiovascolareI ricercatori guidati dalla Johns Hopkins University, hanno scoperto che alcuni fattori sono collegati a un restringimento cerebrale più...
