Risultati per: Passo 9. Individuare i pazienti fumatori da inviare ad un centro anti-fumo

I dati del progetto Pascnet coordinato dalla Cattolica di Milano

Studio pubblicato nella rivista Nature Communications

Esperti, ‘da depressione ad Alzheimer si studiano nuovi usi”

Biancani: “Proposto per sbloccare l’immobilismo regionale”

IncontraDonna, grazie al teatro benefici mentali e relazionali

Studio del Policlinico Federico II

Background
Tumourigenesis in right-sided and left-sided colons demonstrated distinct features.

Objective
We aimed to characterise the differences between the left-sided and right-sided adenomas (ADs) representing the early stage of colonic tumourigenesis.

Design
Single-cell and spatial transcriptomic datasets were analysed to reveal alterations between right-sided and left-sided colon ADs. Cells, animal experiments and clinical specimens were used to verify the results.

Results
Single-cell analysis revealed that in right-sided ADs, there was a significant reduction of goblet cells, and these goblet cells were dysfunctional with attenuated mucin biosynthesis and defective antigen presentation. An impairment of the mucus barrier led to biofilm formation in crypts and subsequent bacteria invasion into right-sided ADs. The regions spatially surrounding the crypts with biofilm occupation underwent an inflammatory response by lipopolysaccharide (LPS) and an apoptosis process, as revealed by spatial transcriptomics. A distinct S100A11+ epithelial cell population in the right-sided ADs was identified, and its expression level was induced by bacterial LPS and peptidoglycan. S100A11 expression facilitated tumour growth in syngeneic immunocompetent mice with increased myeloid-derived suppressor cells (MDSC) but reduced cytotoxic CD8+ T cells. Targeting S100A11 with well-tolerated antagonists of its receptor for advanced glycation end product (RAGE) (Azeliragon) significantly impaired tumour growth and MDSC infiltration, thereby boosting the efficacy of anti-programmed cell death protein 1 therapy in colon cancer.

Conclusion
Our findings unravelled that dysfunctional goblet cells and consequential bacterial translocation activated the S100A11-RAGE axis in right-sided colon ADs, which recruits MDSCs to promote immune evasion. Targeting this axis by Azeliragon improves the efficacy of immunotherapy in colon cancer.

L’impianto di un nuovo stent evita l’intervento a cuore aperto

Potranno effettuare in un’unica giornata tutti gli esami

Nasce anche grazie al supporto dei clienti di Despar Nord

Oncologi, la preservazione della fertilità tra le nuove problematiche

Attese dei letti rallentano accessi:12 minuti in più per ogni malato

This case series examines treatment with anti–programmed cell death 1 (PD1) immunotherapy for patients with basal cell nevus syndrome.

Abolire alcol e attenzione a stili vita per proteggere cuore

Ricoverato il 60%, il 13,5 in terapia intensiva, mortalità 10,6%