Head of pancreas mass with biliary obstruction: an unusual cause

Case presentation A woman in her 70s presented to an Australian centre with right upper quadrant pain, fevers and weight loss. She was born in Greece, having lived in Australia for 50 years. Significant background included chronic lymphocytic leukaemia (CLL), treated with venetoclax and rituximab. Her white cell count was 3.20×109/L with normal liver function tests, bilirubin of 6 µmol/L and C reactive protein of 15 mg/L. Cross-sectional imaging with CT found intrahepatic, extrahepatic, common bile duct dilatation (CBD) to 11 mm, pancreatic duct dilatation to 6 mm (a ‘double duct’ sign) and prominent para-aortic, coeliac and porta lymph nodes (figure 1A). Tumour markers including CA19-9 were normal. She was treated with intravenous ceftriaxone and metronidazole for suspected cholangitis. MR cholangiopancreatography was performed finding widespread upper abdominal lymph nodes suggestive of metastatic disease, with a 4 mm ampullary lesion (figure 1B). A CT chest was performed, showing…

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Gennaio 2025