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SARS-CoV-2, the virus that causes COVID-19, has previously been identified in certain species of wildlife, including white-tailed deer. But new research in Nature Communications suggests it may be common in other types of wildlife, especially species living near high-trafficked human areas.
Autore/Fonte: The American Journal of Gastroenterology
We read with interest the article by Luxenburger and Thimme, summarising current knowledge about hepatic sequelae in the context of SARS-CoV-2 infection.1 As acute liver injury is observed in one-third of the patients with hospitalised COVID-192 3 and chronic liver disease is associated with higher mortality rates,4 a detailed understanding of hepatic susceptibility and dysfunction in the context of SARS-CoV-2 infection is of utmost importance. Previous studies have provided evidence of hepatic infection,5–7 however, the molecular mechanisms underlying acute liver injury associated with SARS-CoV-2 infection are not well understood. Here we show that primary human hepatocytes (PHH) can be productively infected with SARS-CoV-2. Donor-specific production kinetics were observed, with de novo viral secretion from PHH increasing in a time-dependent manner for four out of six donors (figure 1A). To explore virus replication and…
Altri 17 pazienti con sintomi sospetti sono in osservazione
Altri 17 pazienti con sintomi sospetti sono in osservazione
This randomized clinical trial evaluates the efficacy of oral nirmatrelvir-ritonavir for treatment of moderate to severe postacute sequelae of SARS-CoV-2 infection of 3 months or longer duration.
Studio coordinato da Istituto Spallanzani e San Raffaele Milano
Studio coordinato da Istituto Spallanzani e San Raffaele Milano
“I dati provenienti da diversi Paesi sono spesso insufficienti”
Objectives
To assess the seroprevalence of infection-acquired SARS-CoV-2 and the mental health of school/daycare staff in the months after reopening of schools in Montreal, Quebec (Canada) in the Fall of 2020 and whether these varied by school and participant characteristics.
Design
A cross-sectional design based on a convenience sample of schools/daycares and staff was used as the originally planned longitudinal design was no longer feasible due to obstacles in recruitment, for example, teacher’s strike.
Setting
Forty-nine schools/daycares in four Montreal neighbourhoods from March to October 2021.
Participants
Three-hundred and sixty-two participants completed both questionnaires and serology tests.
Primary and secondary outcome measures
SARS-CoV-2 seroprevalence and prevalence of anxiety, depression, resilience and burnout/emotional exhaustion.
Results
The seroprevalence estimate made representative to the Quebec population of educators was 8.6% (95% CI 5.2 to 13.0). The adjusted seroprevalence in high school was 20% that of elementary school (aRR=0.20, 95% CI 0.07 to 0.58). Thirty per cent of seropositive staff were exposed to a household member with confirmed COVID-19. Prevalence of high emotional exhaustion/burnout was 35%, 44% and 53% in daycare, elementary school and high school staff, respectively. However, moderate/severe anxiety and depression and low resilience did not exceed 18%. After adjusting for confounders, being very afraid of catching COVID-19 at school was associated with moderate–severe anxiety, moderate–severe depression and high emotional exhaustion (aRR=4.4, 95% CI 2.2 to 8.9; aRR=2.8, 95% CI 1.5 to 5.4; aRR=2.2, 95% CI 1.6 to 3.0, respectively).
Conclusion
The seroprevalence, anxiety and depression among school/daycare staff were comparable to the reported levels in the adult population of Quebec. The prevalence of emotional exhaustion/burnout was high across all school levels and exceeding the average across all occupations in the USA and in teachers in Germany.
E’ un camionista proveniente dal Congo, via Uganda
I giorni di incubazione, le eventuali rare complicanze. Nel 2024 14mila casi
Tutto l’equipaggio è in quarantena, nessuno può sbarcare
Previsti maggiori controlli alla frontiera e negli aeroporti
In Italia nessun caso in agosto. Sorvegliato il sottotipo Clade
Riccardi, nessun caso di variante aggressiva in regione
