Search Results for: Nanotubi di DNA per terapie contro i tumori del cervello

Oncologia pediatrica sostenuta da chef Romito e da Jre-Italia

Purpose
The Understanding America Study (UAS) is a probability-based Internet panel housed at the Center for Economic and Social Research at the University of Southern California (USC). The UAS serves as a social and health sciences infrastructure for collecting data on the daily lives of US families and individuals. The collected information includes survey data, DNA from saliva samples, information from wearables, contextual and administrative linkages, ecological momentary assessments, self-recorded narratives and electronic records of financial transactions. The information collected focuses on a defining challenge of our time—identifying factors explaining racial, ethnic, geographic and socioeconomic disparities over the life course, including racial discrimination, inequalities in access to education and healthcare, differences in physical, economic and social environments, and, more generally, the various opportunities and obstacles one encounters over the life course. The UAS infrastructure aims to optimise engagement with the wider research community both in data dissemination and in soliciting input on content and methods. To encourage input from the research community, we have reserved 100 000 min of survey time per year for outside researchers, who can propose to add survey questions four times a year.

Participants
The UAS currently comprises about 15 000 US residents (including a 3500-person California oversample) recruited by Address-Based Sampling and provided with Internet-enabled tablets if needed. Surveys are conducted in English and Spanish.

Findings to date
Since the founding of the UAS in 2014, we have conducted more than 600 surveys, including a sequence of surveys collecting biennial information on health and retirement (the complete Health and Retirement Study instrument), 11 cognitive assessments, personality, knowledge and use of information on Social Security programme rules, work disability and subjective well-being. Several hundreds of papers have been published based on the collected data in the UAS. Studies include documentations of the mental health effects of the COVID-19 pandemic and how this varied across socioeconomic groups; comparisons of physical activity measured with accelerometers and by self-reports showing the dramatic biases in the latter; extensive studies have shown the power of using paradata in gauging cognitive change over time; several messaging experiments have shown the effectiveness of information provision on the quality of decision-making affecting well-being at older ages.

Future plans
The UAS national sample is planned to grow to 20 000 respondents by 2025, with subsamples of about 2500 African American, 2000 Asian and 3000 Hispanic participants and an oversample of rural areas. An increasing amount of non-interview data (contextual information, data from a suite of wearables and administrative linkages) is continually being added to the data files.

Prof Mutti: domani convegno internazionale su cure future

Tra le iniziative di Rachele Sacco anche il ‘bus rosa’

Novità e terapie per la patologia in un evento ad Alghero

Objective
This study aimed to determine the prevalence of the negative D antigen phenotype, adherence to routine antenatal anti-D immunoglobulin prophylaxis (RAADP) administration and D antigen sensitisation among pregnant women in the UAE.

Design
Data was collected from pregnant women enrolled in the Mutaba’ah Study. The Mutaba’ah Study is an ongoing prospective mother and child cohort study in the UAE. Data were extracted from the medical records and baseline questionnaire administered to the participants between May 2017 and January 2021.

Setting
The study was conducted in Al Ain city of the UAE.

Participants
A total of 5080 pregnant women residing in Al Ain participated in the study.

Outcome measures
The study estimated the prevalence of negative D antigen phenotype and the provision of RAADP in this population.

Results
Of the 5080 pregnant women analysed, 4651 (91.6%) had D antigen positive status, while 429 (8.4%) were D-negative. D antigen sensitisation was low at 0.5%, and there was a high uptake of RAADP in the population at 88.8%.

Conclusions
The adherence to RAADP is consistent with published data from other healthcare settings. Knowledge of the prevalence of D antigen negative mothers is crucial to the financial and resource consideration for implementing antenatal foetal cell-free DNA screening to determine foetal D antigen status.

Allarme di Ail, si riduce la mortalità ma aumentano le diagnosi

In fondazione Prada la seconda giornata di incontri

Identifica quelli che rispondono un enzima riparatore del dna

Marzi, “importante intervento tempestivo e integrato”

Introduction
Organoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been developed from various malignancies. The characteristics of the original tumour tissue such as mutation signatures, phenotype and genetic diversity are well preserved in organoids, thus showing promising results for the use of this model in translational research. In this study, we aim to assess whether we can generate PDOs from head and neck squamous cell carcinoma (HNSCC) samples and whether PDOs can be used to predict treatment sensitivity in HNSCC patients as well as to explore potential biomarkers.

Methods and analysis
This is a prospective observational study at a single centre (Guy’s and St Thomas’ NHS Foundation Trust) to generate PDOs from patients’ samples to assess treatment response and to correlate with patients’ treatment outcomes. Patients will be included if they are diagnosed with HNSCC undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers and they will be categorised into three groups (cohort 1: primary surgery, cohort 2: primary radiotherapy and cohort 3: recurrent/metastatic disease). Research tumour samples will be collected and processed into PDOs and chemosensitivity/radiosensitivity will be assessed using established methods. Moreover, blood and other biological samples (eg, saliva) will be collected at different time intervals during treatment and will be processed in the laboratory for plasma and peripheral blood mononuclear cell (PBMC) isolation. Plasma and saliva will be used for circulating tumour DNA analysis and PBMC will be stored for assessment of the peripheral immune characteristics of the patients as well as to perform co-culture experiments with PDOs. SOTO study (correlation of the treatment Sensitivity of patient-derived Organoids with Treatment Outcomes in patients with head and neck cancer) uses the collaboration of several specialties in head and neck cancer and has the potential to explore multiple areas of research with the aim of offering a valid and effective approach to personalised medicine for cancer patients.

Ethics and dissemination
This study was approved by North West-Greater Manchester South Research Ethics Committee (REC Ref: 22/NW/0023) on 21 March 2022. An informed consent will be obtained from all participants prior to inclusion in the study. Results will be disseminated via peer-reviewed publications and presentations at international conferences.

Trial registration number
NCT05400239.

Al Senato la legge che punta a potenziare l’assitenza per chi soffre di patologie reumatologiche che colpiscono almeno 5 milioni di italiani

Premio da accademia europea per la neurologia.Nel 2023 Helsinki

Premio da accademia europea per la neurologia.Nel 2023 Helsinki

Coordina l’Università Cattolica, approccio ‘vedo e curo’