The colonisation and assembly of the neonatal microbiota is essential for the development and maturation of the immune system, and the early life from birth to 2 years of age is regarded as a crucial window period. Abnormal microbial colonisation and reduced gut microbiota diversity during this period are linked to the subsequent development of immune-mediated diseases. Dysbiosis of intestinal microbiota in early life can promote dysfunction of the CD4+ T-cell population,1 impacting the development of the child’s immune system and increasing the risk of atopic diseases. Atopic diseases are excessive IgE-mediated immune responses that commonly affect the nose, eyes, skin and lungs. Of these, atopic dermatitis (AD), a chronic and recurring inflammatory skin disease, affects at least 10%–20% of children, often starting in infancy and continuing into adulthood.2 The factors influencing AD are complex. Researchers have conducted meta-analyses of the various factors correlating to…
Breast milk components modulate gut microbiota to increase susceptibility to atopic dermatitis in early life
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Dicembre 2024
