Systematic Review Examines GLP-1s Drugs’ Effectiveness and Safety in Patients Without Diabetes

A systematic review of randomized clinical trials involving about 15 500 participants without diabetes found that all 12 of the identified glucagon-like peptide-1 (GLP-1) receptor agonists led to decreased body mass, waist circumference, and blood pressure. Of the 3 commercially available agents—liraglutide, semaglutide, and tirzepatide—the latter resulted in the greatest weight loss, with participants reporting up to an 18% change in body weight after nearly 17 months.

Leggi
Marzo 2025

Pathways to Sustainable GLP-1 Receptor Agonist Off-Ramping

To the Editor The Viewpoint by Manne-Goehler et al on developing a sustainable pathway for obesity care with glucagon-like peptide-1 receptor agonists (GLP-1RAs) is timely and addresses a critical issue for the future of effective obesity management. This article highlights the urgent need to explore not only the coverage and optimal treatment duration for GLP-1RAs but also strategies for off-ramping, defined as “the tapering or withdrawal of a GLP-1RA after [the optimal] treatment period and its replacement by an alternative approach to weight maintenance.” The authors propose a research agenda focused on studying safe off-ramping strategies, including approaches that integrate a Food is Medicine approach, define the optimal duration of GLP-1RA therapy before off-ramping, explore broader health and metabolic implications of off-ramping, and identify factors that predict successful transitions and long-term maintenance of outcomes for patients.

Leggi
Marzo 2025