Questo è quello che abbiamo trovato per te
Al Senato la legge che punta a potenziare l’assitenza per chi soffre di patologie reumatologiche che colpiscono almeno 5 milioni di italiani
Autore/Fonte: BMJ
To the Editor Mahama et al administered a qualitative survey to assess the fear of cancer recurrence for 51 survivors of localized cutaneous melanoma. The authors found that despite good prognoses, approximately 75% of survivors had fear of cancer recurrence that was negatively associated with their psychological well-being, which, as noted by the authors, aligned with prior studies among patients with melanoma. Surprisingly, Mahama et al observed similar levels of clinical fear of cancer recurrence in patients with stage 0 and stage I to IIA localized cutaneous melanoma despite the fact that patients with stage 0 have a prognosis approaching 100% 5-year melanoma-specific survival. A systematic review of 46 studies found that 82% of survivors of thyroid cancer scored 13 or higher on the Fear of Cancer Recurrence Inventory (FCRI), suggesting that patients with melanoma and thyroid cancer share high levels of cancer worry despite relatively high survival rates compared with other cancers.
In Reply We appreciate the thoughtful response by Akama-Garren and Hartman regarding ways of reducing fear of cancer recurrence (FCR) among patients with localized melanoma. They proposed 2 potential solutions: (1) psychological support (which we also proposed) and (2) changing terminology to recategorize melanoma in situ as melanocytic lesions with low risk of progression. In this reply, we discuss both proposals.
Ricercatore Università Firenze, “li utilizziamo da 5 anni”
Regina Elena, primi 2 casi clinici.A pazienti le cure più mirate
Con nivolumab più ipilimumab. Dieci anni fa il tasso di sopravvivenza era al 25% dopo un anno
Dal sistema immunitaria, per contrastare metastasi e recidive
New England Journal of Medicine, Ahead of Print.
New England Journal of Medicine, Ahead of Print.
Grazie alla combinazione con una molecola.
Grazie alla combinazione con una molecola.
Utile per nuove terapie e diagnosi precoce
Caressa e Bergomi, in ogni campo fondamentale gioco di squadra
Heritability is a factor that has been demonstrated to be strongly associated with the diagnosis of cutaneous melanoma, and there are several inherited gene variants that have been identified as melanoma risk alleles. Previous studies have mainly focused on invasive melanoma or on melanoma irrespective of invasiveness. In this issue of JAMA Dermatology, Ingold et al present their investigation on the influence of germline genetic variation on the risk of developing in situ vs invasive melanoma. The study by Ingold et al is a notable attempt to unravel a complicated biology as melanoma in situ traditionally is considered as a precursor to invasive melanomas, and the idea that these lesions in a sense represent different class of tumors with different etiology is unproven. The authors conducted this study using 5 different datasets of populations with European ancestry (from the UK, Finland, and Australia), with more than 10 000 and more than 3000 patients in total with invasive and in situ melanomas, respectively, together with more than 500 000 controls. The study is a meta-analysis of the different cohorts, assessing associations between common single-nucleotide variant (SNV) genotypes, comparing (1) invasive melanoma with controls, (2) in situ melanoma with controls, and (3) invasive melanoma with in situ melanoma (case-case analysis). Further, 3 separate bioinformatics approaches were applied: (1) genome-wide association study (GWAS) to identify significant chromosomal risk loci, (2) polygenic risk score (PRS) analyses based on 64 497 SNVs to identify joint score combining identified variants that had a P value threshold less than .10 in the case-case GWAS meta-analysis, and (3) SNV-based heritability, which is a method to assess how much of the variation in a trait can be explained by the cumulative effect of SNVs.
This genome-wide association study meta-analysis evaluates whether differences in risk of in situ melanoma and invasive melanoma are heritable.
