Ricerche realizzate da Cnr e università di Bari e Milano
Risultati per: Studio REDUCE-IT e appropriatezza prescrittiva degli acidi grassi omega-3
Questo è quello che abbiamo trovato per te
The SEE-IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: study protocol for an interventional feasibility randomised controlled trial
Introduction
Accurate and timely dispatch of emergency medical services (EMS) is vital due to limited resources and patients’ risk of mortality and morbidity increasing with time. Currently, most UK emergency operations centres (EOCs) rely on audio calls and accurate descriptions of the incident and patients’ injuries from lay 999 callers. If dispatchers in the EOCs could see the scene via live video streaming from the caller’s smartphone, this may enhance their decision making and enable quicker and more accurate dispatch of EMS. The main aim of this feasibility randomised controlled trial (RCT) is to assess the feasibility of conducting a definitive RCT to assess the clinical and cost effectiveness of using live streaming to improve targeting of EMS.
Methods and analysis
The SEE-IT Trial is a feasibility RCT with a nested process evaluation. The study also has two observational substudies: (1) in an EOC that routinely uses live streaming to assess the acceptability and feasibility of live streaming in a diverse inner-city population and (2) in an EOC that does not currently use live streaming to act as a comparator site regarding the psychological well-being of EOC staff using versus not using live streaming.
Ethics and dissemination
The study was approved by the Health Research Authority on 23 March 2022 (ref: 21/LO/0912), which included NHS Confidentiality Advisory Group approval received on 22 March 2022 (ref: 22/CAG/0003). This manuscript refers to V.0.8 of the protocol (7 November 2022). The trial is registered with the ISRCTN (ISRCTN11449333). The first participant was recruited on 18 June 2022.
The main output of this feasibility trial will be the knowledge gained to help inform the development of a large multicentre RCT to evaluate the clinical and cost effectiveness of the use of live streaming to aid EMS dispatch for trauma incidents.
Trial registration number
ISRCTN11449333.
Mixed-methods feasibility study to inform a randomised controlled trial of proton pump inhibitors to reduce strictures following neonatal surgery for oesophageal atresia
Objectives
This mixed-methods feasibility study aimed to explore parents’ and medical practitioners’ views on the acceptability and design of a clinical trial to determine whether routine prophylactic proton pump inhibitors (PPI) reduce the incidence of anastomotic stricture in infants with oesophageal atresia (OA).
Design
Semi-structured interviews with UK parents of an infant with OA and an online survey, telephone interviews and focus groups with clinicians. Data were analysed using reflexive thematic analysis and descriptive statistics.
Participants and setting
We interviewed 18 parents of infants with OA. Fifty-one clinicians (49 surgeons, 2 neonatologists) from 20/25 (80%) units involved in OA repair completed an online survey and 10 took part in 1 of 2 focus groups. Interviews were conducted with two clinicians whose survey responses indicated they had concerns about the trial.
Outcome Measures
Parents and clinicians ranked the same top four outcomes (‘Severity of anastomotic stricture’, ‘Incidence of anastomotic stricture’, ‘Need for treatment of reflux’ and ‘Presence of symptoms of reflux’) as important to measure for the proposed trial.
Results
All parents and most clinicians found the use, dose and duration of omeprazole as the intervention medication, and the placebo control, as acceptable. Parents stated they would hypothetically consent to their child’s participation in the trial. Concerns of a few parents and clinicians about infants suffering with symptomatic reflux, and the impact of this for study retention, appeared to be alleviated through the symptomatic reflux treatment pathway. Hesitant clinician views appeared to change through discussion of parental support for the study and by highlighting existing research that questions current practice of PPI treatment.
Conclusions
Our findings indicate that parents and most clinicians view the proposed Treating Oesophageal Atresia with prophylactic proton pump inhibitors to prevent STricture (TOAST) trial to be feasible and acceptable so long as infants can be given PPI if clinicians deem it clinically necessary. This insight into parent and clinician views and concerns will inform pilot phase trial monitoring, staff training and the development of the trial protocol.
Flash glucose monitoring in young people with type 1 diabetes–a qualitative study of young people, parents and health professionals: 'It makes life much easier
Objectives
Flash glucose monitoring for patients with T1 diabetes avoids frequent painful finger-prick testing, thus potentially improving frequency of glucose self-monitoring. Our study aimed to explore experiences of young people using Freestyle Libre sensors and their parents, and to identify benefits and challenges to National Health Service (NHS) staff of its adoption in their care provision.
Participants
Young people with T1 diabetes, their parents and healthcare professionals were interviewed between February and December 2021. Participants were recruited via social media and through NHS diabetes clinic staff.
Design
Semistructured interviews were conducted online and analysed using thematic methods. Staff themes were mapped onto normalisation process theory (NPT) constructs.
Results
Thirty-four participants were interviewed: 10 young people, 14 parents and 10 healthcare professionals. Young people reported that life was much easier since changing to flash glucose monitoring, increasing confidence and independence to manage their condition. Parents’ quality of life improved and they appreciated access to real-time data. Using the NPT concepts to understand how technology was integrated into routine care proved useful; health professionals were very enthusiastic about flash glucose monitoring and coped with the extra data load to facilitate more tailored patient support within and between clinic visits.
Conclusion
This technology empowers young people and their parents to understand their diabetes adherence more completely; to feel more confident about adjusting their own care between clinic appointments; and provides an improved interactive experience in clinic. Healthcare teams appear committed to delivering improving technologies, acknowledging the challenge for them to assimilate new information required to provide expert advice.
Una borsa di studio intitolata a Francesco Ripa di Meana
Per tre volte presidente Fiaso, è scomparso un mese fa a 72 anni
In Memoriam: Dr. Frank Davidoff: Leading Annals as It Entered the 21st Century
Annals of Internal Medicine, Ahead of Print.
Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial
Objectives
The risk factors for prematurity are multifactorial and include low omega-3 status. Omega-3 supplementation in pregnancy has been found to reduce prematurity risk, particularly among women with low omega-3 levels. This study aimed to identify maternal characteristics that predict whether women with a singleton pregnancy will benefit from omega-3 supplementation to reduce their risk of prematurity.
Design
Exploratory analyses of a multicentre, double-blind randomised trial.
Setting
6 tertiary care centres in four states in Australia.
Participants
5328 singleton pregnancies in 5305 women recruited before 20 weeks of gestation.
Interventions
Fish oil capsules containing 900 mg omega-3 long-chain polyunsaturated fatty acids per day versus vegetable oil capsules consumed from enrolment until 34 weeks’ gestation.
Outcome measures
Early preterm birth (EPTB,
Ictus lieve, studio suggerisce pazienti che peggioreranno
Univ. Cattolica, orienta su come trattare i casi più a rischio
Studio Usa, esercizio fisico all'aperto migliora memoria
‘fitness verde’, piu’ benefici neurologici che ginnastica
it was
It wasn’t her face. It wasn’t her age, or the story, or the blood. It wasn’t even the hole
“it was”: Saying More With Less
Poetry has many techniques to convey meaning wordlessly. The poem “it was” demonstrates some of the most effective.
WHO: Nations Must Do More to Reduce Salt Consumption by 2025
In 2013, 194 countries committed to a World Health Organization (WHO) goal of reducing global sodium intake, which in excess can increase people’s risk of heart disease, stroke, and premature death, by 30% by 2025. A report published by the WHO, however, showed that the world is not on track to meet that target.
Chiarire il profilo di sicurezza del paracetamolo nei pazienti affetti da COVID-19 in assistenza domiciliare: uno studio di coorte nel mondo reale, con analisi caso-controllo nidificate, nell’assistenza primaria
Covid: studio, possibili relazioni con fattori meteorologici
Ricercatori Unimore, esiste una ‘finestra climatica’ ottimale
In Italia il primo studio sull’uso delle Car-T contro i tumori solidi
Ha un’efficacia che supera il 60% la prima terapia in grado di curare, con buona probabilità di successo, le forme più gravi di neuroblastoma. La ricerca, pubblicata sul New England Journal of Medicine, apre speranze anche per altri tipi di cancro
Il vino potrebbe proteggere il cuore dai grassi dannosi
Ipotesi del Negrar, agisce su ceramidi che favoriscono placche