Ipotesi del Negrar, agisce su ceramidi che favoriscono placche
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Il vino potrebbe proteggere il cuore dai grassi dannosi
Ipotesi del Negrar, agisce su ceramidi che favoriscono placche
Il vino potrebbe proteggere il cuore riducendo grassi dannosi
Ipotesi del Negrar, agisce sui ceramidi che favoriscono le placche
In older adults with hypertension, chlorthalidone vs. hydrochlorothiazide did not reduce major CV events or deaths at 2.4 y
Annals of Internal Medicine, Ahead of Print.
Physicians Say an Idaho House Bill That Would Criminalize Administering mRNA Vaccines Is an Attack on the Medical Profession—Even If It Doesn’t Become Law
This Medical News article discusses a bill introduced in Idaho that would ban administering mRNA vaccines.
It’s Like a Death
In this narrative medicine essay, a neurosurgeon works through his grief over ending his surgical career due to intractable pain from an elbow injury by appreciating what he can do instead of focusing on what he lost.
Studio Unife, ostriche di Goro alleate di salute e ambiente
Analisi dell’Ateneo svela proprietà varietà ‘golden’ e ‘black’
Studio, sale fa male anche quando non fa alzare la pressione
Favorisce formazioni di placche nelle coronarie e nelle carotidi
INCIDENTAL DYSPLASIA DURING TOTAL PROCTOCOLECTOMY WITH ILEOANAL POUCH: IS IT ASSOCIATED WITH WORSE OUTCOMES?
Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer. In cases of invisible or non-endoscopically resectable dysplasia found at colonoscopy, total proctocolectomy with ileal pouch anal anastomosis can be offered with good long-term oncological outcomes and pouch survival, however, little is known regarding cancer-related outcomes when dysplasia is found incidentally after surgery. We hypothesized incidental colorectal dysplasia is associated with worse oncologic outcomes compared to dysplasia diagnosed preoperatively.
DEVELOPMENT OF A NOVEL DRUG DELIVERY SYSTEM (DDS) TO DELIVER DRUGS DIRECTLY TO THE COLONIC MUCOSA TO IMPROVE EFFICACY AND REDUCE SYSTEMIC EXPOSURE FOR THE TREATMENT OF ULCERATIVE COLITIS (UC)
The clinical remission rate in moderate to severe ulcerative colitis (UC) and Crohn’s Disease (CD) has plateaued at ∼15-20% despite the approval of multiple therapeutics. Research has shown that an inadequate amount of drug at the disease site in the colon may be responsible for limited clinical benefit. The Drug Delivery System (DDS) is an ingestible electronic targeted delivery device containing a localization system to autonomously identify colon entry based on gastrointestinal (GI) anatomy, independent of the variable GI physiological conditions deliver a bolus dose of a liquid drug formulation to the colon mucosa to improve efficacy and reduce systemic toxicity.
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Postoperative delirium (POD) is common. It is associated with increased morbidity and mortality. Many cases may be preventable and melatonin offers promise as a preventative agent.
Objective
This systematic review provides an up-to-date synthesis of the evidence on the effect of melatonin in preventing POD.
Design
A systematic search of randomised controlled trials of melatonin in POD was run across multiple databases (EMBASE, MEDLINE, CINAHL, PsycINFO) and a clinical trials registry (ClinicalTrials.org) (1 January 1990 to 5 April 2022). Studies examining the effects of melatonin on POD incidence in adults are included. Risk of bias was assessed using the Cochrane risk of bias 2 tool.
Outcome measures
The primary outcome is POD incidence. Secondary outcomes are POD duration and length of hospital stay. Data synthesis was undertaken using a random-effects meta-analysis and presented using forest plots. A summary of methodology and outcome measures in included studies is also presented.
Results
Eleven studies, with 1244 patients from a range of surgical specialties were included. Seven studies used melatonin, in variable doses, and four used ramelteon. Eight different diagnostic tools were used to diagnose POD. Time points for assessment also varied. Six studies were assessed as low risk of bias and five as some concern. The combined OR of developing POD in the melatonin groups versus control was 0.41 (95% CI 0.21 to 0.80, p=0.01).
Conclusion
This review found that melatonin may reduce the incidence of POD in adults undergoing surgery. However, included studies displayed inconsistency in their methodology and outcome reporting. Further work to determine the optimum regime for melatonin administration, along with consensus of how best to evaluate results, would be beneficial.
PROSPERO registration number
CRD42021285019.
Studio Usa, negli occhi i primi segni dell'Alzheimer
Tumori:ogni studio fa risparmiare 1 mln in cure e assistenza
Ma Italia investe solo 1,43% Pil. Schillaci, ora invertire rotta. Oggi guarisce fino al 90% dei bambini
Tumori:ogni studio fa risparmiare 1 mln in cure e assistenza
Ma Italia investe solo 1,43% Pil. Schillaci, ora invertire rotta
Epidemiologia della psoriasi pediatrica: uno studio di popolazione utilizzando due fonti dati italiane
An mRNA Influenza Vaccine — Could It Deliver?
New England Journal of Medicine, Volume 388, Issue 12, Page 1139-1141, March 2023.