Search Results for: I numeri del cancro in Italia 2019

Circulation, Volume 150, Issue Suppl_1, Page A4145081-A4145081, November 12, 2024. Background:The incidence of stroke in young adults is on the rise in the United States. Drug abuse has been proposed as a known modifiable risk factor for stroke in this age group. The association between cannabis use and stroke in young adults is an area that needs further exploration.Research Hypothesis:Cannabis is an independent modifiable risk factor for stroke in young adults with Cannabis Use Disorder(CUD).Aim:To investigate the association between Cannabis Use Disorder(CUD) and Stroke in young adults.Methods:Using the National Inpatient Sample 2019, admissions for stroke in the age group of 18-45 were identified. The cohort was subdivided into admissions with documented CUD. Demographic data of the cohort was analyzed, including the prevalence of comorbid conditions. Using multivariate binomial logistic regression, the association between cannabis use and the occurrence of stroke was studied, after accounting for age, smoking, cocaine abuse, and uncontrolled hypertension(HTN). A two-tailed p-value

Circulation, Volume 150, Issue Suppl_1, Page A4147276-A4147276, November 12, 2024. Background:Although the number of women who smoke is growing among patients with ST-segment elevation myocardial infarction (STEMI), this population is poorly documented.Aim:Using a French nationwide MI cohort, we aimed to analyze gender-specific characteristics and hospital outcomes of active smokers hospitalized for acute STEMI.Methods:The French Cohort of Myocardial Infarction Evaluation (FRENCHIE) is a large ongoing AMI cohort, collecting data from all patients hospitalized for AMI within 48 h of symptom onset in 21 French centers. STEMI patients admitted from 2019 to 2022 were analyzed. Smoking status was self-declared. Past or never smokers were excluded from the analysis. Combined in-hospital events included death or ventricular fibrillation (VF).Results:Among the 9258 STEMI patients, 3761 (40.6%) were current smokers, of whom 702(18.7%) were women. Women were in average 4 years older than men (57.9 ± 11.0 vs 54.3 ± 10.0 y, p

Circulation, Volume 150, Issue Suppl_1, Page A4112716-A4112716, November 12, 2024. Background:Deaths from congenital heart disease (CHD) in children have been decreasing in the United States. We examined the differences in mortality trends between Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) infants.Methods:We retrospectively analyzed publicly available data from the Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (CDC WONDER). The data was obtained from the linked birth/infant deaths from 2005 to 2019. We evaluated all infant deaths up to 1 year of age with the cause of death listed as CHD (International classification of diseases, 10threvision (ICD-10) codes Q20-Q26 (except atrial septal defect, Q21.1 and patent ductus arteriosus, Q25. CHD infant mortality rate (IMR) was calculated per 100,000 live births. Race was ascertained based on death certificate reporting. Joinpoint regression was used to examine CHD-IMR by year, including stratification by NHB vs NHW, and neonatal vs postneonatal. The difference between NHB and NHW CHD-IMR was ascertained via the Mann-Whitney U test. P

Circulation, Volume 150, Issue Suppl_1, Page A4139875-A4139875, November 12, 2024. Background and Purpose:Older adults in the United States face worsening trends in the incidence and prevalence of comorbid diabetes mellitus (DM) and heart failure (HF). This study aimed to examine the trends in DM and HF-related mortality among adults ≥65 years in the United States.Methods:The Multiple Cause-of-Death data using CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research) were analyzed for DM and HF-related deaths from 1999 to 2019 in adults ≥65 years. Age-adjusted mortality rates (AAMRs) per 100,000 population were determined and stratified by year, sex, race/ethnicity, and geographic region. Joinpoint regression was used to analyze trends in AAMRs using annual percent change (APC).Results:A total of 842,785 deaths occurred among older adults in the United States related to comorbid HF and DM. The overall AAMR for deaths due to comorbid DM and HF in older adults was 97.4. The AAMRs remained stable between 1999 and 2005. From 2005 to 2009, AAMRs steadily declined at an APC of -3.41 (95% CI: -4.75 to -0.52). Following a period of stability from 2009 to 2014, AAMRs increased at an APC of 2.80 (95% CI: 1.97 to 4.68) till 2019. Men (116.2) had consistently higher AAMRs than older women (84.8) throughout the study period. Upon stratification by race and ethnicity, AAMRs were observed to be highest in non-Hispanic (NH) American Indian or Alaska Native (144.1), followed by NH Black or African American (124.4), Hispanic or Latino (100.5), NH White (95.3), and NH Asian or Pacific Islander (62.0) populations. Non-metropolitan areas had higher AAMRs for comorbid HF and DM than metropolitan areas, with overall AAMRs of 126.9 and 90.9, respectively. States that fell into the top 90thpercentile included Kentucky, Mississippi, Oklahoma, Oregon, Vermont, and West Virginia, which had twice the AAMRs than states that fell into the bottom 10thpercentile, including Arizona, Florida, Hawaii, Massachusetts, Nevada, and New York.Conclusion:Our analysis revealed a concerning rise in mortality related to comorbid DM and HF in U.S. adults ≥ 65 years old since 2014. Men, NH American Indian and Alaska Native populations, and residents of non-metropolitan areas displayed the highest AAMRs. Future efforts focusing on improved risk assessment and the adoption of therapeutic therapies are needed for the effective management of patients with comorbid DM and HF to help alleviate the mortality burden.

Circulation, Volume 150, Issue Suppl_1, Page A4141011-A4141011, November 12, 2024. Background:Significant coronary artery disease has been suggested as the main cause of the refractory state among patients with out-of-hospital cardiac arrest (OHCA) and initial ventricular fibrillation (VF).Research Question/Hypothesis:The aim of this study was to describe the coronary angiography findings in relation to degree of treatment refractoriness, measured as the number of shocks, among patients with shockable OHCA in Sweden.We hypothesized that increasing number of shocks was associated with an increased prevalence of coronary artery disease (CAD) and more frequent percutaneous coronary intervention (PCI).Methods:All patients with primary VF OHCA in Sweden between January 1, 2010, and December 31, 2019, who underwent coronary angiography, were included using three national registries. Patients were divided according to the number of delivered defibrillations and subgrouped according to presence of STEMI on ECG. Coronary angiography findings of acute occlusions, PCI performed, chronic total occlusions as well as multivessel disease were described in relation to level of refractoriness.Results:In total, 3369 patients were included. Among them 67%/N=2270 required 1-3 defibrillations, 23%/N=758 4-6, 7%/N=222 7-9 and 4%/N=119 ≥10 defibrillations. There was no significant difference regarding acute coronary occlusions between the groups. The proportion of patients receiving PCI decreased with increased number of shocks (67%/N=1525 for 1-3 shocks, 58%/N=435for 4-6 shocks, 54%/N119 for 7-9 shocks and 55%/N=65 for ≥10 shocks). This was true for both subgroups with or without STEMI. Survival and neurological function decreased in accordance with increased need of defibrillations (74% to 35%; p=

Circulation, Volume 150, Issue Suppl_1, Page A4146669-A4146669, November 12, 2024. Background:In advanced severe degenerative mitral regurgitation (asDMR, i.e., C2 to D stage DMR), an overt deterioration of the mitral valve (MV) apparatus and left ventricular (LV) enlargement are typically observed. The negative impacts of a mismatch between the left ventricular end-systolic dimension (LVESD) and MV ring size on mitral regurgitation (MR) recurrence have been established in secondary MR, while its impacts on asDMR prognosis remains unknown.Hypothesis:LVESD/MV ring size ratio may impact on asDMR prognosis.Goals:To verify the impact and to reveal its side effects.Methods:We retrospectively analyzed patients diagnosed with asDMR who underwent mitral valve repair and annuloplasty from 2008 to 2019. Patients were followed up to April 2024. Primary outcomes included 10-year moderate or severe mitral stenosis (MS), recurrent MR, and death. Prosthetic orifice areas (POA) were obtained from official instructions. LVESD/POA was introduced as a novel parameter to identify LV-MV mismatch and non-mismatch.Results:A total of 450 eligible patients were enrolled. During the follow-up of 5.8 ± 2.3 years, 60 recurrent MRs, 71 MSs, and 46 deaths were observed. At 3rd, 5th, and 10th years after surgery, rates of freedom from recurrent MR were 98.1%, 92.4%, and 65.4%, respectively; rates of freedom from MS rates were 99.0%, 94.9%, and 59.4%, respectively; survival rates were 97.8%, 94.9%, and 69.6%, respectively. In multivariable Cox regression analysis, only a larger LVESD/POA ratio (HR: 3.50; 95% CI: 1.98-6.16; p < 0.001) was associated with recurrent MR. ROC curve determined an optimal LVESD/POA cutoff value of 11.52 mm/m2(AUC = 0.88, p < 0.001) for recurrent MR prediction. In subgroup analysis, mismatch group (LVESD/POA > 11.52 mm/m2) had higher cumulative recurrent MR rate (log-rank p < 0.001), MS rate (log-rank p < 0.001), and survival rate (log-rank p < 0.001). In mismatch group, ring cohort exhibited higher cumulative MS rate (log-rank p = 0.027) and higher cumulative recurrent MR rate (log-rank p = 0.013). However, in the non-mismatch group, the cumulative MS and MR rates were comparable between the ring and band cohorts (log-rank p = 0.53).Conclusion:LV-MV mismatch annuloplasty increases the risks of recurrent MR, MS, and death. LVESD/POA ratio effectively predicts recurrent MR in asDMR. In patients with significant LV dilation, a posterior band may be preferable to a complete ring for downsized annuloplasty.

Circulation, Volume 150, Issue Suppl_1, Page A4140693-A4140693, November 12, 2024. Introduction:Patients presenting to the emergency department (ED) with chest pain are frequently admitted to inpatient or observation units. We sought to assess gender, racial, and ethnic variations in the care of chest pain patients presenting to the ED.Methods:A retrospective chart review of patients presenting to UF Health Shands ED from 6/2019–12/2023 with chest pain was conducted. We included patients with high-sensitivity troponin I levels below the 99thpercentile (

Circulation, Volume 150, Issue Suppl_1, Page A4141165-A4141165, November 12, 2024. Background:Current evidence supports the use of the Ross procedure (pulmonary autograft) in adults with aortic valve disease.Aims:To examine the ten-year clinical and echocardiographic outcomes following the Ross procedure using a tailored approach.Methods:This prospective cohort included 455 consecutive adults (333 male [73.1%]) with a median age of 50.0 years (IQR, 40.0-57.0) undergoing a Ross procedure at a single center. Patients with aortic aneurysms (37.4%), previous cardiac surgery (15.2%) and active endocarditis (5.7%) were included. The predominant lesion was aortic stenosis (AS) in 379 patients (83.3%) and aortic insufficiency (AI) in 76 patients (16.7%). The study period ranged from February 1, 2011, to December 31, 2019. Primary endpoints were cumulative incidence of any, autograft, or homograft reintervention, and time-related valve function (AI grades 0-4). The secondary endpoint was ten-year survival among Ross patients compared with that in the age- and sex-matched Canadian population. Median clinical follow-up was 6.0 years (maximum 13 years). Follow-up was 90% complete for clinical and 87% complete for echo follow-up.Results:Operative mortality was 0.4% (n=2). Both patients were operated among the first 100 cases. At 10 years, cumulative incidence of any aortic and/or pulmonary reintervention was 5.0% (95% CI, 2.3-9.4%); autograft reintervention 1.5% (0.5-3.4%); and homograft reintervention 3.4% (1.9-5.7%). In patients with preoperative AS, cumulative incidence of autograft reintervention was 1.8% at 10 years (0.6-4.1%), versus 0% in patients with preoperative AI (p=0.6) (Figure 1). At 10 years, cumulative incidence of AI grade >2 was 2.0% (0.9-4.2%), and did not differ between patients with preoperative AS or AI (p=0.9) (Figure 1). Ten-year survival was 96.5% (95% CI, 94.7-98.7%), translating to a relative survival of 100% (99.4-100%) compared to the matched general population.Conclusion:This study demonstrates that using a tailored surgical approach and contemporary perioperative management strategies, the Ross procedure is associated with excellent long-term valve function and freedom from reintervention in an all-comer adult patient population. Moreover, it translates into restored late survival, mimicking the general population. These results further support the notion that, in reference centers, the Ross procedure should be considered in adults needing valve replacement.

Circulation, Volume 150, Issue Suppl_1, Page A4140505-A4140505, November 12, 2024. Introduction:Syncope is a common condition often leading to testing and hospital admissions. Research assessing sex-based differences in the workup as well as disposition following emergency department (ED) syncope visits is scarce. In this study, we sought to address this gap using a national database.Methods:From 2010 to 2019, we identified syncope patients using ICD-9 and ICD-10 codes. Using data from the IBM MarketScan Research Database, which captures de-identified individual-level health data from approximately 100 commercial payers and self-insured corporations in the United States, we assessed the incidence of testing using CPT codes in the 3 months following syncope diagnosis. Furthermore, we evaluated the percentage of syncope patients discharged from the ED. Sex-based comparisons were performed using the Chi-square test.Results:A total of 557,416 patients (54.0% women) were included in the cohort to assess for testing disparities (these are the patients who had at least 3 months of continuous enrollment following syncope diagnosis). Compared to men, women had significantly lower testing in most domains: long-term monitoring (6.8% vs. 7.4%), echocardiogram (13.3% vs. 17.2%), cardiac stress test (4.0% vs. 7.4%), chest X-ray (17.7% vs. 25.5%), imaging for pulmonary embolism (1.5% vs. 2.0%) and carotid Doppler ultrasound (5.4% vs. 7.3%); p< 0.001 for all above comparisons, figure 1A. Tilt table testing was similar between both sexes (1.4% vs. 1.3%).A total of 1,325,023 patients (58.1% women) were included in the ED disposition cohort. Women presenting to the ED with syncope were more likely to be discharged compared to men (78.7% vs 72.1%; p< 0.001), and this trend remained consistent throughout the study period, figure 1B.Conclusion:Women presenting with syncope are less likely to receive testing compared to men, and more likely to be discharged from the ED. There is a need to evaluate the reasons behind these disparities and assess their impact on patients’ outcomes.

Circulation, Volume 150, Issue Suppl_1, Page ASu302-ASu302, November 12, 2024. Background:In-hospital cardiac arrest occurs in 290,000 patients annually in the United States, with less than 20% of these arrests featuring a shockable presenting rhythm. The three-phase model of CPR is separated into the electrical phase which occurs in the first 4 minutes, the circulatory phase which includes minutes 4-10, and the metabolic phase which is greater than 10 minutes from arrest onset. Defibrillation during the electrical phase has been proven to improve survival by approximately 50%. Current guidelines recommend defibrillation within the first 2 minutes of arrest in those with a rhythm of VT/VF.The purpose of this study was to determine the effect of time to defibrillation on mortality in patients with shockable rhythms.Methods:Full-disclosure rhythm strips for all cardiac arrests in non-ICU patients on telemetry were reviewed from Feb 2019 to April 2023. Time to defibrillation of shockable rhythms (VT/VF) was determined from the telemetry data and corresponding defibrillator data from the Zoll CodeNet electronic system.Results:We identified 32 of the 186 patients with cardiac arrest while on telemetry presenting with pulseless monomorphic VTor polymorphic VT/VF. The average time to defibrillation was 4.8 min ± 2.7 min. 34% of patients were defibrillated in 4 minutes or less from the onset of the arrythmia, 31% were defibrillated in more than 4 minutes from the onset of the arrythmia, and 34% were not defibrillated. Patients defibrillated in 4 minutes or less had a significantly lower mortality of 36.4% compared to a 50% mortality of those defibrillated in more than 4 minutes and 90.9% mortality in those not defibrillated (p

Circulation, Volume 150, Issue Suppl_1, Page ASa105-ASa105, November 12, 2024. After the implemetation of special emergency services, advanced airway management(AAM) in cardiac arrest has been tried actively. We aim to compare the success rates and patient outcomes of supraglottic airway(SGA), endotracheal intubation with direct laryngoscope(ETI with DL), and endotracheal intubation with video laryngoscope(ETI with VL) in patients with sudden cardiac arrest, and evaluate the effectiveness of the video laryngoscope in the pre-hospital stage.This study was conducted on cardiac arrest patients who transferred to ED by EMS from July 2019 to December 2021. Using the Korean OHCA registry, EMS ambulance runsheet, and cardiac arrest in-depth registry, patients with sudden cardiac arrest over 18 years old, caused by medical cause, and who were treated by the special EMS team at the site and got AAM were enrolled. Cases with unknown information on AAM success or time of arrival/death were excluded. Pre-hospital ROSC, 72 hr survival, survival to discharge, good neurological outcome were compared among SGA, ETI with DL and ETI with VL using multivariable logistic regression. Initial AAM success and final success rates were also compared.10,587 cases were enrolled in the study, of which 9379 cases got SGA, 493 ETI with DL, and 985 ETI with VL. In the first attempt, the insertion success rate is higher with SGA, but the overall success is higher with VL. For any prehospital ROSC, compared to SGA, ETI with DL was 1.33 (1.00-1.75), and ETI with VL was 1.92 (1.57-2.34). Compared to SGA, aOR for survival within 72 hours was 1.13 (0.81-1.56), 1.34 (1.06-1.70), survival to discharge was 1.05 (0.64-1.65), 1.06 (0.74-1.49), and good neurological outcome was 0.64 (0.31-1.25), 1.17(0.71-1.86) in ETI with DL or ETI with VL respectively. Compared to the SGA, aOR of the initial success was 0.44 (0.32-0.61) and 0.48 (0.38-0.62) in the ETI with DL and ETI with VL groups, respectively, and the final success rate was 0.78 (0.45-1.44), 1.14 (0.72-1.94).Endotracheal intubation in EMS showed the lower initial success rate than SGA, but when using a video-laryngoscope, the final success rate rises to a sufficiently similar level, and the pre-hospital ROSC success rate is higher than that of SGA.

Circulation, Volume 150, Issue Suppl_1, Page A4146823-A4146823, November 12, 2024. Introduction:This study examines trends in heart failure admissions, cardiogenic shock, mechanical circulatory support (MCS) usage, and cardiac transplant among patients with congenital heart disease (CHD), focusing on double (DV) and single ventricle (SV) CHD.Methods:We analyzed the national inpatient sample from 2016 to 2020 for heart failure admissions, including double and single ventricle CHD, and trends in cardiogenic shock, MCS utilization, cardiac transplants, and mortality.Results:Out of 4,963,884 total admissions, 29,805 were for DV-CHD and 2,415 for SV-CHD. Patients without CHD were older (mean age 71.5 years) than those with DV-CHD (mean age 59.8 years) and SV-CHD (mean age 17.9 years). Non-CHD patients had shorter stays (mean 5.8 days), and lower total charges. CHD admissions remained stable from 2016 to 2020. Cardiogenic shock rates were highest among SV-CHD patients, with significant fluctuations, followed by DV-CHD patients. MCS usage increased, particularly among SV-CHD patients, while DV-CHD patients showed an upward trend and patients without CHD had consistently lower usage. Heart transplant rates were low but increased slightly in 2020 for patients without CHD, with DV and SV CHD patients showing fluctuating rates peaking in 2018 and 2019, then declining in 2020. Inpatient mortality rates were highest among SV-CHD patients, followed by DV-CHD patients, both experiencing significant fluctuations and a general increasing trend, while patients without CHD had the lowest and most stable rates.Conclusion:Our analysis highlights trends in CHD management, including age, length of stay, mortality rates, and healthcare costs. Variations in cardiogenic shock, MCS usage, and cardiac transplants emphasize the need for adaptive clinical practices to optimize patient outcomes.

Circulation, Volume 150, Issue Suppl_1, Page A4114276-A4114276, November 12, 2024. Introduction:The association between left bundle branch block (LBBB) and heart failure is well-established. However, the lack of a practical risk assessment tool for patients with LBBB poses a clinical challenge to the management despite the heterogeneity of the LBBB population.Hypothesis:Artificial intelligence (AI) can extract features to stratify the risk of heart failure (HF) within the heterogeneity of LBBB.Methods:All 12-lead ECGs diagnosed with LBBB recorded from 1/1/2015 to 12/31/2019 were identified in our institution. ECG data were analyzed as 2D matrices with a shape of 12×2500. The Uniform Manifold Approximation and Projection (UMAP) was used to visualize the heterogeneity of LBBB ECG. Additionally, a 2-dimensional convolutional neural network model was trained to detect LBBB ECGs associated with past HF diagnosis. The model was then applied to ECGs from an external cohort of patients with LBBB but without a history of HF. Cumulative incidences of HF admission were compared by stratifying according to tertiles of the model output (low, intermediate and high AI score groups)Results:We identified 15,124 LBBB ECGs in our institution (training dataset) and 2,463 individuals with LBBB ECGs in the external cohort (external test dataset). The UMAP projection of the ECGs revealed distinct heterogeneity in the data (Fig A). This heterogeneity was not fully explained by patient demographics, ECG features, or institutions. When the external cohort was divided into 3 groups according to the tertile of AI prediction, patients with high AI scores had a higher risk of HF admission (high vs low AI score group: hazard ratio (HR), 2.10; 95% confidence interval (CI), 1.66-2.65; intermediate vs low AI score group: HR, 1.39; 95%CI, 1.08-1.78: log-rank p

Circulation, Volume 150, Issue Suppl_1, Page A4137855-A4137855, November 12, 2024. Background:The current guideline-recommended intervention for left main (LM) disease is coronary artery bypass grafting (CABG). Hybrid coronary revascularization (HCR) combines robotic coronary artery bypass and percutaneous coronary intervention (PCI) and offers a less invasive approach for patients with LM and multivessel coronary artery disease. We aim to compare clinical outcomes at 30 days, 6 months and 1 year between HCR and CABG in patients with LM disease.Methods:We retrospectively screened 761 patients who underwent bypass for LM disease between 2019 and 2023 at a single institution. A total of 118 patients who underwent either HCR (n=59) or CABG (n=59) were included after propensity matching for baseline characteristics. The primary endpoint was major adverse cardiovascular events (MACE), defined as death, myocardial infarction, repeat revascularization and stroke, at 30 days, 6 months and 1 year, which was assessed using chi-squared tests. Secondary outcomes are individual components of MACE at 30 days, 6 months and 1 year. Kaplan-Meier curves were used to visualize the difference in 1-year cumulative MACE-free survival across groups coupled with a log-rank test.Results:The mean age was 68.93±11 years for HCR patients and 68.41±10.11 years for CABG patients (p=0.394). SYNTAX score was high ( > 33) for 49.1% of HCR patients and 67.3% of CABG patients (p=0.15). Hospital length of stay was shorter for HCR compared to CABG (4.07 ± 1.21 days vs. 7.58 ± 7.71 days, p

Circulation, Volume 150, Issue Suppl_1, Page A4145541-A4145541, November 12, 2024. Background:While physical activity (PA) is associated with a lower risk of atrial fibrillation (AF), prior studies have observed a higher prevalence of AF among athletes. Therefore, we sought to characterize the association between PA and the risk for AF in a large cohort of healthy adults with relatively high levels of self-reported leisure time PA levels.Methods:Individual participant data from the Cooper Center Longitudinal Study were linked to Medicare administrative claims files. PA volume (MET-min/wk), duration of moderate (< 6 METs), and duration of vigorous PA (≥ 6 METs) PA were measured by self-report at study entry. Other risk factors such as age, current smoking status, weekly alcohol consumption, BMI, blood glucose, systolic blood pressure, and cholesterol were measured using a standard approach. AF was identified using Medicare claims. A proportional hazards illness-death model was used to estimate hazard ratios for incident atrial fibrillation and multivariable-adjusted for all measured baseline covariates.PA was evaluated as an ordinal variable (< 500, 500-1499, 1500-3000, and ≥ 3,000 MET-min/week). In analyses for subtype of activity, moderate and vigorous activity were mutually adjusted and evaluated as a continuous covariate (per hour).Results:We included 26,549 participants (71.9% men, mean age 54 years at baseline), who received Medicare coverage from 1999 to 2019. After 195,343 person-years of Medicare follow-up time, we observed 3,939 cases of AF. Higher PA was associated with a modest increase in the risk for AF above 1,500 MET-min/week, but with less precision at PA above 3,000 MET-min/week (Figure 1). We also observed vigorous activity, but not moderate activity, was associated with higher risk of AF (Figure 2).Conclusion:After accounting for covariates, higher PA volume was associated with increased risk of AF at doses more than 3x the guideline-recommended amount. These associations appear to be more apparent for vigorous exercise intensity.

Circulation, Volume 150, Issue Suppl_1, Page A4139661-A4139661, November 12, 2024. Introduction:Troponin-defined myocardial injury or N-terminal pro-B-type natriuretic peptide (NT-proBNP) elevation frequently coincides with coronavirus disease 2019 (COVID-19). Our prior study (COVID-MI Registry Cohort-1) confirmed that high-sensitive troponin I (HsTnI) and NT-proBNP effectively stratified mortality risk. However, variants of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) change rapidly, and it remains unclear whether these biomarkers are consistently effective in predicting prognosis of COVID-19 patients irrespective of epidemic periods.Research Questions:Can HsTnI or NT-proBNP stratify mortality risk in recent COVID-19 cohorts?Aims:To assess the potential of HsTnI and NT-proBNP levels for risk stratification in the recent COVID-19 waves.Methods:In the COVID-MI Registry Cohort-2, we enrolled 1115 consecutive COVID-19 patients admitted between October 2021 and October 2022, during the Omicron variant endemic. We collected data of HsTnI or NT-proBNP levels from hospital charts or using the samples in our hospital’s serum/plasma bank if the data were not available. The primary outcome measure was all-cause mortality.Results:On admission, more than one-third of patients were classified as having severe COVID-19. HsTnI and NT-proBNP levels were available for 427 and 414 patients, respectively. The median HsTnI and NT-proBNP levels were 16 (interquartile range [IQR]: 5-57) ng/L and 524 (IQR: 140-2056) pg/mL, respectively. We stratified the patients into three groups by HsTnI level: