Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty

To the Editor A recent study showed that aspirin, compared with enoxaparin, resulted in a significantly higher rate of symptomatic VTE within 90 days in patients undergoing hip or knee arthroplasty for osteoarthritis. Mortality from pulmonary embolism after hip and knee arthroplasty has decreased significantly over the past few decades and now remains low regardless of the prophylaxis drug used. Other improvements in perioperative care have played an important role in reducing the mortality rate. In this study, every hospital could provide all patients with pneumatic compression calf devices and compression stockings, which may have contributed to the low incidence of VTE.

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Gennaio 2023

High- vs Low-Dose Tranexamic Acid Infusion and Need for Red Blood Cell Transfusion and Adverse Events in Cardiac Surgery—Reply

In Reply In response to the comments by Dr Koster and colleagues, the OPTIMAL trial enrolled patients aged 18 to 70 years, which is the age range of most patients undergoing adult cardiac bypass surgery in China. We agree that our study results, especially regarding seizures, should be interpreted with caution for patients older than 70 years.

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Gennaio 2023