To the Editor We have some comments about the limitations of the CRISTAL trial, which evaluated the effect of aspirin vs enoxaparin on symptomatic VTE in patients undergoing hip or knee arthroplasty.
Risultati per: Terapia antibiotica: breve durata vs. lunga durata
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Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty
To the Editor A recent study showed that aspirin, compared with enoxaparin, resulted in a significantly higher rate of symptomatic VTE within 90 days in patients undergoing hip or knee arthroplasty for osteoarthritis. Mortality from pulmonary embolism after hip and knee arthroplasty has decreased significantly over the past few decades and now remains low regardless of the prophylaxis drug used. Other improvements in perioperative care have played an important role in reducing the mortality rate. In this study, every hospital could provide all patients with pneumatic compression calf devices and compression stockings, which may have contributed to the low incidence of VTE.
Ipertensione correlata alla terapia del cancro
Hydrochlorothiazide vs. Chlorthalidone for Hypertension
A randomized trial showed no difference in cardiovascular outcomes or mortality.
In older adults with recent MI, polypill vs. usual care reduced major adverse CV events at 3 y
Annals of Internal Medicine, Ahead of Print.
In T1DM, open-source automated insulin delivery increased glucose time in target vs. sensor-augmented pumps
Annals of Internal Medicine, Ahead of Print.
In type 2 diabetes, glargine and liraglutide each improved glycemic outcomes at 5 y vs. glimepiride or sitagliptin
Annals of Internal Medicine, Ahead of Print.
In rheumatic heart disease–associated AF, rivaroxaban increased adverse vascular outcomes vs. VKA at 3 y
Annals of Internal Medicine, Ahead of Print.
In type 2 diabetes, liraglutide reduced CV events at 5 y vs. glargine, glimepiride, or sitagliptin
Annals of Internal Medicine, Ahead of Print.
In T1DM, open-source automated insulin delivery increased glucose time in target vs. sensor-augmented pumps
Annals of Internal Medicine, Ahead of Print.
In older adults with recent MI, polypill vs. usual care reduced major adverse CV events at 3 y
Annals of Internal Medicine, Ahead of Print.
In type 2 diabetes, liraglutide reduced CV events at 5 y vs. glargine, glimepiride, or sitagliptin
Annals of Internal Medicine, Ahead of Print.
In type 2 diabetes, glargine and liraglutide each improved glycemic outcomes at 5 y vs. glimepiride or sitagliptin
Annals of Internal Medicine, Ahead of Print.
In rheumatic heart disease–associated AF, rivaroxaban increased adverse vascular outcomes vs. VKA at 3 y
Annals of Internal Medicine, Ahead of Print.
Remifentanil vs Neuromuscular Blockers and Intubation Without Major Complications Among Patients at Risk of Aspiration
This randomized trial assesses the effect of remifentanil vs neuromuscular blockers on successful intubation without major complications among patients at risk of aspiration during rapid sequence intubation in the operating room.
High- vs Low-Dose Tranexamic Acid Infusion and Need for Red Blood Cell Transfusion and Adverse Events in Cardiac Surgery—Reply
In Reply In response to the comments by Dr Koster and colleagues, the OPTIMAL trial enrolled patients aged 18 to 70 years, which is the age range of most patients undergoing adult cardiac bypass surgery in China. We agree that our study results, especially regarding seizures, should be interpreted with caution for patients older than 70 years.