Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements

To the Editor A recent Research Letter reported that temperatures measured by temporal thermometers are lower than those measured orally in Black patients but not in White patients. However, I am concerned that this study used race as a proxy for skin color. Because people can have a range of skin colors despite their so-called race, the results of this study would have been more meaningful if it had used a biological parameter with one of the more objective measurements of skin color, such as a spectrophotometer or one of the visual scales.

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Gennaio 2023

Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements—Reply

In Reply We thank the authors for their comments about our recent article exploring racial differences in the accuracy of temporal thermometers. We agree with Dr Newman that self-reported race is an imperfect proxy for skin color. If differences in skin color are the basis of the temperature differences observed between oral and temporal thermometers, the magnitude of the difference would be better measured using an objective measure of skin color in a prospective study rather than self-reported race in a retrospective data analysis.

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Gennaio 2023

Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma—Reply

In Reply We agree with Ms Hu and Dr Kao that the current NCCN guidelines recommend definitive radiotherapy with or without concurrent chemotherapy for NPC with stage II and T3N0 disease, and in this subset, induction or adjuvant chemotherapy only for patients with high-risk features including bulky tumor volume or high serum EBV DNA copy number. Our study excluded patients who had NPC with high-risk features, so all patients with low-risk NPC were not treated with induction or adjuvant chemotherapy. Although triweekly delivery of cisplatin has been the standard regimen for concurrent chemotherapy, a phase 2 clinical trial comparing weekly and triweekly cisplatin during radiotherapy reported that the therapeutic effect and acute reactions of triweekly regimen were similar to that of the weekly regimen. However, other studies have reported significantly greater hematological toxicity but lower gastrointestinal reactions with a weekly cisplatin regimen.

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Gennaio 2023

Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma

To the Editor The National Comprehensive Cancer Network (NCCN) guidelines currently recommend that concurrent chemoradiotherapy be the primary treatment for patients with T1-2N1M0, T3N0M0, and T2N0M0 NPC with high-risk features. A recent study reported that patients with low-risk stage II and T3N0M0 cancer who received IMRT alone had the same oncologic outcomes but better long-term quality of life than those who received concurrent chemoradiotherapy. We have 3 concerns about the definition of the truly low-risk NPC.

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Gennaio 2023

Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty

To the Editor A recent study showed that aspirin, compared with enoxaparin, resulted in a significantly higher rate of symptomatic VTE within 90 days in patients undergoing hip or knee arthroplasty for osteoarthritis. Mortality from pulmonary embolism after hip and knee arthroplasty has decreased significantly over the past few decades and now remains low regardless of the prophylaxis drug used. Other improvements in perioperative care have played an important role in reducing the mortality rate. In this study, every hospital could provide all patients with pneumatic compression calf devices and compression stockings, which may have contributed to the low incidence of VTE.

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Gennaio 2023

Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty—Reply

In Reply First, we would like to address some of the concerns about the issue of confounding from unmeasured variables (anesthesia type and postoperative rehabilitation) that was mentioned by Dr Chia-Chien Hsu and colleagues. Due to the randomized, crossover design of our study, each participating cluster (hospital) served as its own control. This design provided balancing of baseline variables (Table 1 in the article) and likely also resulted in balancing of unmeasured covariates.

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Gennaio 2023