Search Results for: Carenza di vitamina B12: diagnosi e gestione

Background
Maternal vitamin B12 levels during pregnancy have been implicated in the risk of preterm birth, but current evidence remains controversial and just focuses on measurements during pregnancy.

Objective
To assess the association of maternal periconception serum vitamin B12 concentration, including levels before conception and at early gestation, with the risk of preterm birth and its subtypes in a large Chinese population.

Design
Prospective cohort study.

Participants
A total of 26 977 women from Shanghai, China, with serum vitamin B12 concentration measured either before conception or at early gestation.

Outcome measures
Preterm birth was defined as delivery before 37 weeks of gestation and was stratified as preterm birth

Lo screening neonatale ha ridotto l’ipotiroidismo congenito

Manca diagnosi in 65% casi. Pediatri: ‘enuresi ha cause fisiche’

Manca diagnosi in 65% casi. Pediatri: ‘enuresi ha cause fisiche’

Benefici anche con 2,5-5 ore di camminata veloce a settimana

Benefici anche con 2,5-5 ore di camminata veloce a settimana

Diabetologi, impatto di 14miliardi anno,pari a10% costi sanitari

Oltre 40 mila casi all’anno, con test feci diagnosi precoce

Objectives
Vitamin B12 deficiency is a common and neglected adverse effect experienced by type 2 diabetic patients treated with metformin. A lack of vitamin B12 may have severe consequences, such as fatigue, macrocytic anaemia and worsened peripheral diabetic neuropathy. This study aims to identify the rate of vitamin B12 deficiency and the associated factors in type 2 diabetic patients treated with metformin.

Design
Cross-sectional study.

Setting and participants
This study involved 145 type 2 diabetic patients treated with metformin in Cho Ray hospital, a tertiary healthcare centre in South Vietnam. The levels of vitamin B12 and associated clinical and paraclinical parameters were measured and collected.

Results
The study population’s mean age was 61.5 years, of which 51.7% were women. The median duration of metformin use was 10 years, and the median metformin dose was 1700 mg. The vitamin B12 deficiency rate was 22.1%. HbA1c, duration of metformin use and metformin dose were independent factors statistically associated with vitamin B12 deficiency.

Conclusions
This study identified the rate of vitamin B12 deficiency and associated factors in type 2 diabetic patients treated with metformin. These findings can be helpful in screening patients and replacing vitamin B12 in high-risk populations with vitamin B12 deficiency.

Trial registration number
Ethical Committee of Cho Ray Hospital (approval number 1711/CN-HĐĐĐ)

Neglet e l’afasia tra principali problemi lungo termine malattia

Grazie al progetto Telemo realizzato dal Cnr di Pisa

Latronico, rafforzamento del sistema di emergenza sanitaria