Il provvedimento darà copertura a 1,5 milioni di cittadini in più. Cittadinanzattiva: «Così si evita che milioni di persone restino senza medico di base»
Risultati per: Passo 13. Analizzare le codifiche dei propri assistiti per ottimizzare le analisi
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Carenza dei medici di base, 1000 assistiti alle guardie mediche
Approvato Dl Inps. Per curare 1,5 milioni di italiani in più
Analisi sull’uso dei farmaci anti-osteoporotici in sette database europei
Comparative effects of non-alcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease on risk of incident cardiovascular events: a meta-analysis of about 13 million individuals
We read with interest the report on comparative risks of liver-related and cardiovascular disease (CVD) outcomes among lean and obese patients with non-alcoholic fatty liver disease (NAFLD) by Younes et al.1 Recently, international experts proposed redefining NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD).2 The impact of this name change on CVD risk prediction is not known. We performed a meta-analysis of observational cohort studies (by searching PubMed, Scopus and Web of Science from database inception to 30 June 2022) that simultaneously used the NAFLD and MAFLD definitions for examining the risk of incident CVD events associated with both definitions, among adults with and without either NAFLD or MAFLD, and in which hepatic steatosis was diagnosed by imaging techniques or blood biomarkers/scores. Studies using liver biopsy were not available. The primary outcomes were CVD mortality, non-fatal CVD events or both. Data from selected studies were…
Il lunedì è il giorno nero per il cuore, +13% infarti
Studio su oltre 10mila pazienti, il ritmo circadiano è determinante
Telethon, il Piano malattie rare è un importante passo avanti
Ora raggiungere intesa su modalità di assegnazione delle risorse
Case 16-2023: A 13-Year-Old Boy with Depression and Hypotension
New England Journal of Medicine, Volume 388, Issue 21, Page 1992-1999, May 2023.
==Schillaci, 'oblio oncologico è passo contro diseguaglianze'
‘Legge è necessaria, così colmeremo il gap con altri Paesi Ue’
==Schillaci, 'oblio oncologico è passo contro diseguaglianze'
‘Legge è necessaria, così colmeremo il gap con altri Paesi Ue’
Arriva ad Aosta il Tour della Salute, il 13 e 14 maggio
Consulti medici gratuiti in venti piazze italiane
Il 13 maggio la giornata per la prevenzione del cancro orale
In piazze e studi iniziativa di Fondazione Andi, visite gratuite
Scotti (Fimmg): “MMG, serve un cambio di passo”
Integrazione dati MMG su Rapporto Agenas personale sanitario, Silvestro Scotti (Fimmg): «Dati coerenti con la nostra denuncia sulla desertificazione della medicina territoriale. Ora si proceda ad un deciso cambio di passo»
Case 13-2023: A 25-Year-Old Woman with Abdominal Pain and Jerking Movements
New England Journal of Medicine, Volume 388, Issue 17, Page 1609-1615, April 2023.
Chiarire il profilo di sicurezza del paracetamolo nei pazienti affetti da COVID-19 in assistenza domiciliare: uno studio di coorte nel mondo reale, con analisi caso-controllo nidificate, nell’assistenza primaria
Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling
Objective
The contribution of vitamin D (VD) deficiency to the pathogenesis of allergic diseases remains elusive. We aimed to define the impact of VD on oesophageal allergic inflammation.
Design
We assessed the genomic distribution and function of VD receptor (VDR) and STAT6 using histology, molecular imaging, motif discovery and metagenomic analysis. We examined the role of VD supplementation in oesophageal epithelial cells, in a preclinical model of IL-13-induced oesophageal allergic inflammation and in human subjects with eosinophilic oesophagitis (EoE).
Results
VDR response elements were enriched in oesophageal epithelium, suggesting enhanced VDR binding to functional gene enhancer and promoter regions. Metagenomic analysis showed that VD supplementation reversed dysregulation of up to 70% of the transcriptome and epigenetic modifications (H3K27Ac) induced by IL-13 in VD-deficient cells, including genes encoding the transcription factors HIF1A and SMAD3, endopeptidases (SERPINB3) and epithelial-mesenchymal transition mediators (TGFBR1, TIAM1, SRC, ROBO1, CDH1). Molecular imaging and chromatin immunoprecipitation showed VDR and STAT6 colocalisation within the regulatory regions of the affected genes, suggesting that VDR and STAT6 interactome governs epithelial tissue responses to IL-13 signalling. Indeed, VD supplementation reversed IL-13-induced epithelial hyperproliferation, reduced dilated intercellular spaces and barrier permeability, and improved differentiation marker expression (filaggrin, involucrin). In a preclinical model of IL-13-mediated oesophageal allergic inflammation and in human EoE, VD levels inversely associated with severity of oesophageal eosinophilia and epithelial histopathology.
Conclusions
Collectively, these findings identify VD as a natural IL-13 antagonist with capacity to regulate the oesophageal epithelial barrier functions, providing a novel therapeutic entry point for type 2 immunity-related diseases.
In Italia 13,4 mln di persone soffrono di insonnia, 60% donne
Marzo mese del sonno, Sognid’oro lancia progetto con Aims