Risultati per: Trattamento della sindrome dell'intestino irritabile (IBS)

Possono migliorare risposta immunitaria o indebolirla

Family practitioners commonly manage irritable bowel syndrome (IBS) with the use of dietary modifications, antispasmodics, laxatives, or anti-diarrheal drugs. If these first-line therapies fail to improve symptoms, neuromodulators such as amitriptyline are recommended as a second-line treatment. However, amitriptyline is infrequently prescribed for the management of IBS in primary care as its efficacy has not previously been studied in this setting.

People who received low-dose amitriptyline, a tricyclic antidepressant, for irritable bowel syndrome (IBS) symptoms that persisted despite dietary changes and first-line treatments such as analgesics experienced an improvement in IBS severity and symptoms compared with those who received a placebo. More people discontinued the placebo than amitriptyline due to adverse events, according to results from a phase 3 randomized clinical trial involving 463 participants from 55 primary care practices in the UK. In addition, there was no difference between the groups in anxiety, depression, or ability to work after 6 months.

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