Genetic analyses of treatment response in primary care IBS, a pilot study

Recently, a large pragmatic study in 459 primary care patients with IBS comparing treatment outcome after 8 weeks of a diet lowering the intake of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) instructed via a smartphone application (n=218) or the antispasmodic agent otilonium bromide (OB) (n=217) was published.1 Here, we report a genetic survey in this cohort. Data of 390 patients were amenable for genetical analysis after quality control: 192 in the medication arm and 198 in the diet arm. Responder rate was significantly higher in the diet than in the OB group (72% vs 61%, p=0.0014). Response was defined as an improvement of IBS symptom severity score of at least 50 points.1 Genotype data were generated on peripheral blood DNA using Illumina Global Screening Array, and standard quality controls were applied including selection of European ancestry individuals.2 Single-nucleotide polymorphism (SNP) data were…

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Agosto 2023